|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms (HLA haplotypes; rs231806, rs231775, and rs3087243 in CTLA4; rs763361 in CD226; and rs706778 in CD25) and T1D-associated autoantibodies were analyzed.
|
25980680 |
2015 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Both signals in the two variant model for MS affect CD25 expression on distinct subpopulations of CD4+ T cells, which are key cells in the autoimmune process.
|
26106896 |
2015 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations of CLEC16A and IL2RA with MS were validated.
|
25903733 |
2015 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL2RA variants are known to protect against multiple sclerosis, diabetes mellitus and RA.
|
26350950 |
2015 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The proposed procedure is illustrated on a multiple sclerosis (MS) family data set including genotypes of SNPs in IL2RA, confirming the advantage of using a family design to identify causal variants.
|
25585700 |
2015 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
|
24449572 |
2014 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrated that the frequencies of CD3(+) CD4(+) IL-17(+) Th17 cells were significantly higher, and CD4(+) CD25(+) FOXP3(+) Treg cells significantly lower in peripheral blood mononuclear cells from RA patients.
|
25164131 |
2014 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
|
24449572 |
2014 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we have used a microarray approach to comprehensively analyze miRNA expression signatures of both naive Tregs (CD4+CD45RO-CD25++) and memory Tregs (CD4+CD45RO+CD25+++), as well as conventional naive (CD4+CD45RO-CD25-) and memory (CD4+CD45RO+CD25-) T cells (Tconvs) derived from peripheral blood of RA patients and matched healthy controls.
|
24401767 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The IL2RA and IL7RA variants had univariate association in MS and T1D, whereas the MGAT1 and CTLA-4 variants associated with only MS or T1D, respectively.
|
24572742 |
2014 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although the possibility that IL2RA is a risk factor for MS development was not confirmed in this Japanese population, IL2RA gene polymorphisms were able to modify the disease activity in female MS patients, but had no influence on either susceptibility or disease phenotype in NMO/NMOSD patients.
|
24332945 |
2014 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, similar to MS, the MGAT1 variant haplotype interacted with CTLA4 (P=0.03), and a combination of IL2RA and IL7RA (P=0.01).
|
24572742 |
2014 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We show that an MS-associated polymorphism in the IL-2 receptor alpha (IL2RA) gene specifically increases the frequency of GM-CSF-producing TH cells.
|
25278028 |
2014 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Further characterization of the effect of IL2RA and IL7R genetic variants in defined MS subtypes is warranted to evaluate the effect of these genes on specific clinical outcomes and to further elucidate the mechanisms of disease onset and progression.
|
24770783 |
2014 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed an accumulation of rare nonsynonymous variants exclusive to RA cases in IL2RA and IL2RB (burden test: p = 0.007 and p = 0.018, respectively).
|
23261300 |
2013 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present genetic and serologic data suggest that inherited altered genetic constitution at the IL2RA locus may predispose to a less destructive course of RA.
|
23529819 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Autoantibodies to insulin (IAA), GAD (GADA), insulinoma-associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) were measured in follow-up sera, and genotyping for type 1 diabetes susceptibility genes (HLA-DR/HLA-DQ, INS variable number of tandem repeats [VNTR] and single nucleotide polymorphisms at PTPN22, PTPN2, ERBB3, IL2, SH2B3, CTLA4, IFIH1, KIAA0350 [also known as CLEC16A], CD25, IL18RAP, IL10, COBL) was performed on the DNA samples of children born to a parent with type 1 diabetes and prospectively followed from birth for up to 22 years.
|
23539116 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Three variants were found to be significantly associated with type 1 diabetes (T1D): NLRP1 rs12150220 (OR = 0.71, 95% CI = 0.55-0.92, P = 0.01), IL2RA rs11594656 (OR = 0.86, 95% CI = 0.82-0.91, P<0.00001), and CLEC16A rs725613 (OR = 0.71, 95% CI = 0.55-0.92, P = 0.01).
|
23922971 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the effect of IL2RA risk alleles on T1D may be partially mediated through epigenetic changes.
|
23874506 |
2013 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Flow cytometry was used to study the activation of CD4+ T cells and T cell subsets (CD25(high) and CD26(high) cells), monocytes and DCs in a cross-sectional study of 39 untreated and 29 GA-treated MS patients, the latter followed prospectively for one year.
|
22653658 |
2013 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
Multiple Sclerosis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Here we describe linked intronic variants of MGAT5 that are associated with reduced N-glycan branching, CTLA-4 surface expression and MS (p=5.79×10(-9), n=7,741), the latter additive with the MGAT1, IL2RA and IL7RA MS risk variants (p=1.76×10(-9), OR=0.67-1.83, n=3,518).
|
23351704 |
2013 |
|
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |