|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of IL-5-induced eosinophilia in airway hyperresponsiveness has been questioned.
|
11897983 |
2002 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings provide evidence that local IL-5-mediated eosinophilia is essential in the induction of esophageal remodeling.
|
18166354 |
2008 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-5 is a key factor for eosinophilia and could therefore be responsible for some of the tissue damage seen in chronic asthma.
|
11477111 |
2001 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
After epithelial barrier disruption, intranasal OVA application induced higher OVA-specific IgG1 and total IgE in serum, and increased eosinophilia and interleukin-5 in bronchoalveolar lavage (BAL) compared to sham-OVA mice.
|
31769882 |
2019 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-5 alone was able to generate significant numbers of eos in TG5 but not FVB mice, whereas a combination of IL-5 and IL-9 induced marked eosinophilia in both strains indicating a synergism between these 2 cytokines.
|
11159534 |
2001 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, treatment of humanized mice with anti-Siglec antibody led to robust depletion of IL-5-induced eosinophilia in vivo.
|
30543818 |
2019 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Our in vitro results suggest that IL-5 produced by activated CD4+ T lymphocytes plays a crucial role in the induction of eosinophilia in HES.
|
8425573 |
1993 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that the IL5 gene may play a role in blood eosinophilia associated with atopic dermatitis.
|
14581138 |
2003 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These effects are caused by in utero exposure to maternal IL-5 and resulting fetal eosinophilia.
|
31821769 |
2020 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine if interleukin-5 (IL-5) is implicated in producing the eosinophilia, we performed in situ hybridization studies on cytopreparations of 16 cases of Hodgkin's disease with eosinophilia as well as cells from various controls.
|
2403816 |
1990 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that, in subjects with atopic asthma, inhaled allergen causes trafficking of T lymphocytes to the bone marrow, and that in subjects who develop late responses and greater blood and airway eosinophilia after inhalation of allergen, there is a significant increase in the ability of bone marrow cells, particularly T lymphocytes, to produce IL-5.
|
12231502 |
2002 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
This recent revival in understanding the biologic basis of eosinophilic disorders has permitted more genetic specificity in the classification of these diseases, and has translated into successful therapeutic approaches with targeted agents such as imatinib mesylate and recombinant anti-IL-5 antibody.
|
16781488 |
2006 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data support a role for GM-CSF and IL-3 in the eosinophilia characteristic of CHS and show that IL-5 mRNA expression is not a prominent feature of nonallergic inflammation.
|
8335853 |
1993 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that increased production of IL-5 and GM-CSF from the abnormal CD(3+)4-(8-) cells might cause eosinophilia.
|
8602991 |
1996 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhaled IL-5 modulated eosinophil progenitor numbers in both the airways and bone marrow of asthmatics and induced local eosinophilia in non-asthmatics.
|
17581195 |
2007 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
The presence of eosinophilia in most HD patients and the presence of hyper-IgE in a subset of them may suggest that activated lymph node T cells release large amounts of IL5 and IL4, respectively.
|
9407718 |
1998 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This patient also had marked eosinophilia and high levels of thymus and activation-regulated chemokine and interleukin-5 in the serum.
|
29573413 |
2019 |
|
Eosinophilic disorder
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We investigated whether benralizumab, a monoclonal antibody directed against the alpha subunit of the interleukin-5 receptor that significantly reduces the incidence of asthma exacerbations, was also effective as an oral glucocorticoid-sparing therapy in patients relying on oral glucocorticoids to manage severe asthma associated with eosinophilia.
|
28530840 |
2017 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
TLR4-deficient mice challenged with either OVA preparation showed eosinophilia but not neutrophilia and had increased IL-5.
|
24968337 |
2014 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interleukin (IL)-5 is a key regulator of eosinophilia in allergic inflammation and parasite infections but the mechanisms regulating IL-5 expression in activated human T lymphocytes are poorly understood.
|
17845581 |
2007 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Regulation of IL-5 and eotaxin levels within the lung by IL-4 and IL-13 allows Th2 cells to elegantly co-ordinate tissue and peripheral eosinophilia.
|
11292021 |
2001 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These data are consistent with the hypothesis that the eosinophilia in FE is secondary to dysregulation of IL-5 production in PBMC (and their component subsets).
|
28226398 |
2017 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, anti-IL-5 treatment of IL-5 TG mice decreased both airway eosinophilia and TGF-beta 1 levels in bronchoalveolar lavage fluids and increased airway reactivity.
|
12759459 |
2003 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
All cases expressed the IL-3R but the IL-5R gene was expressed predominantly in leukaemic cells with either t(8;21) or CD4-positive immunophenotype and was associated with the presence of eosinophilia.
|
7577627 |
1995 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
The production of TH2-type cytokines [interleukin-4 (IL-4) and IL-5] and tissue eosinophilia are characteristic features of allergic diseases.
|
11122208 |
2000 |