Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In AB22-inoculated mice detectable serum IL-6 levels were found to precede macroscopically detectable tumour growth, clinical signs (cachexia, abdominal distension, diarrhoea) and changes in the peripheral lymphoid organs (cell depletion and functional depression).
|
7750122 |
1995 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Trier Social Stress Test-induced increases in IL-6 and NF-kappaB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress.
|
16946190 |
2006 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating levels of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumor necrosis factor-alpha-receptor (TNF-RII), and soluble intercellular adhesion molecule (sICAM) did not differ between those with and without depression.
|
17094069 |
2007 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Further bivariate modeling revealed that approximately 10% of the correlation between Beck Depression Inventory and IL-6 could be explained by the SLC6A4 gene.
|
20031642 |
2009 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association between the IL-6 polymorphism and reduced risk of depressive symptoms confirms the role of the inflammatory response system in the pathophysiology of IFN-alpha-induced depression; in contrast, the effect of the 5-HTT gene was small and perhaps dependent on the status of the inflammatory response.
|
18458677 |
2009 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
IL-6 and CRP levels were elevated among those with lifetime depression and, among those with depression only, IL-6 methylation showed an inverse correlation with circulating IL-6 and CRP.
|
20836906 |
2011 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leukocyte telomere length was compared between 18 unmedicated MDD subjects and 17 controls and was correlated with lifetime depression chronicity and peripheral markers of oxidation (F2-isoprostane/Vitamin C ratio) and inflammation (IL-6).
|
21448457 |
2011 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In a 2-year prospective study of a community sample of 521 older people, information on number of physical disorders, diagnosis of depression (Geriatric Mental State), and genotypes for 6 pro-inflammatory (tumor necrosis factor-α -850C/T and -308G/A, interleukin (IL)-1β -511C/T and +3953C/T, IL-6 -174G/C, IL-8 -251T/A) and 2 anti-inflammatory (IL-4 +33T/C, IL-10 -1082G/A) cytokine polymorphisms were ascertained.
|
22921153 |
2013 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
During antiviral treatment we reported that subjects with CC genotype (IL-6) presented significantly lower changes from baseline in IFN-induced depression (p=0.005) and IFN-induced anxiety (p=0.004).
|
23571152 |
2013 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
These results suggest that the plasma levels of IL-6 reflect the severity of MDD and that plasma IL-6 levels might be another biological-state marker for the depressive state.
|
23813968 |
2013 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the plasma levels of IL-6 reflect the severity of MDD and that plasma IL-6 levels might be another biological-state marker for the depressive state.
|
23813968 |
2013 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
RGD |
In the present study, we aimed to investigate the effect of Interleukin-6 (IL-6) on colon motility in a rat model of depression induced by chronic unpredictable mild stress (CUMS).
|
23589140 |
2013 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The homeostatic functions of IL-6 imply that ubiquitous IL-6 inhibitors, for example, tocilizumab, may not be the optimal treatment target in depression.
|
24548241 |
2014 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Changes in the mRNA expression of inflammatory cytokines, including interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and interferon-γ, were not correlated with the decrease in hippocampal neurogenesis or the appearance of depression-like behavior during the chronic phase following irradiation.
|
24491956 |
2014 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the expression of DNMT1/3A, EZH2 and IL-6 genes increases with increasing Hospital Anxiety and Depression Scale-Anxiety scores in the anxious cohort only.
|
25350786 |
2015 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, IL6 genotype did not moderate the effects of non-interpersonal stress exposure (i.e., financial, work and health-related difficulties) on depression.
|
25596176 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
These observations demonstrate that IL6 directly controls SERT levels and consequently serotonin reuptake and identify STAT3-dependent regulation of SERT as conceivable neurobiological substrate for the involvement of IL6 in depression.
|
25760924 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
These observations demonstrate that IL6 directly controls SERT levels and consequently serotonin reuptake and identify STAT3-dependent regulation of SERT as conceivable neurobiological substrate for the involvement of IL6 in depression.
|
25760924 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
However, the expression of DNMT1/3A, EZH2 and IL-6 genes increases with increasing Hospital Anxiety and Depression Scale-Anxiety scores in the anxious cohort only.
|
25350786 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Ketamine suppressed the production of the only established depression-relevant proinflammatory cytokines, IL-6 and TNFα.
|
25903726 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chronic peripheral inflammation mediated by cytokines such as TNFα, IL-1β, and IL-6 is associated with psychiatric disorders like depression and anxiety.
|
26074461 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
RGD |
Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression.
|
27106565 |
2016 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We sought to assess the prevalence of -889C>T IL-1α, -31T>C and -511C>T IL-1β, -330T>G IL-2 and -174G>C IL-6 genes and their association with adiposity and depression in Polish subjects.
|
26934083 |
2016 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, when stratified by IL6 C-174G polymorphism, higher baseline depressive symptom severity measured by MADRS and BDI predicted higher risk of depression in the course of antiviral treatment only in high IL-6 producers-G allele carriers (patients with GG and CG genotypes) (p = 0.004, p = 0.00008, respectively).
|
28083615 |
2016 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, IL-6 and other cytokines may be more relevant in the development of somatic symptoms compared to affective signs of depression, delineating a specific genotype-phenotype relationship in this heterogeneous disorder.
|
26821321 |
2016 |