|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for eGFR, albuminuria, and other traditional cardiovascular risk factors, anemia (1.37, 95% CI 1.09, 1.72, <i>P</i>=0.006), insulin resistance (1.16, 95% CI 1.04, 1.28, <i>P</i>=0.006), hemoglobin A1c (1.27, 95% CI 1.14, 1.41, <i>P</i><0.001), interleukin-6 (1.15, 95% CI 1.05, 1.25, <i>P</i>=0.002), and tumor necrosis factor-α (1.10, 95% CI 1.00, 1.21, <i>P</i>=0.05) were all significantly and directly associated with incidence of heart failure.
|
28515118 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-6 concentration in the plasma of <i>TNFα</i> A-allele carriers at months 1 and 12 after CABG was higher in the HF group compared to the non-HF group (1 month after CABG: 5.3 ± 3.4 vs. 3.1 ± 2.9, p<0.05; 12 months after CABG: 4.2 ± 3,9 vs. 1.4 ± 1.2, p<0.01, respectively).
|
31275366 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Maternal serum concentrations of tumor necrosis factor-α, interleukin-6, soluble Fas ligand, transforming growth factor-α, and vascular endothelial growth factor-D were significantly higher when fetuses had heart failure than when they did not (P < .05), whereas maternal serum concentrations of heparin-binding epidermal growth factor-like growth factor were significantly lower when fetuses had heart failure than when they did not (P < .05).
|
30273582 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mechanistic studies in vitro demonstrated that T lymphocyte culture supernatants stimulated by β<sub>1</sub>-AAmAb caused direct damage in the cardiomyocytes, and β<sub>1</sub>-AAmAb promoted proliferation of T lymphocytes isolated from patients with heart failure and increased IL-6 release.
|
30747396 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL6 is strongly and independently associated with ASCVD events, HF, and all-cause mortality, particularly among statin users.
|
30312930 |
2018 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
After further adjustment for biomarkers (high-sensitivity C-reactive protein, lipoprotein-associated phospholipase A<sub>2</sub> activity, high-sensitivity troponin I, and B-type natriuretic peptide), IL-6 remained significantly associated with the risk of major adverse cardiovascular events (adj HR Q4:Q1 1.43, 95% CI 1.09-1.88) and cardiovascular death or heart failure (adj HR 1.79, 95% CI 1.22-2.63).
|
29066436 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, RORα protects against ANG II-mediated pathological hypertrophy and heart failure by suppressing the IL-6-STAT3 pathway and enhancing mitochondrial function.
|
30387679 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
RGD |
Role of inflammatory cytokines and chemoattractants in the rat model of streptozotocin-induced diabetic heart failure.
|
18999900 |
2008 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
RGD |
SHR displayed early stage of heart failure as shown by increased heart weight/body weight ratio and relative wall thickness by echocardiography, downregulated myocardial beta(1)-adrenoceptor, and upregulated myocardial brain natriuretic peptide and interleukin-6 (IL6).
|
18280594 |
2008 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF, elevated IL-6 predicted HF hospitalization and all-cause mortality, while SAA level was only associated with all-cause mortality.
|
28542263 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We studied the cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta and IL-6 and the terminal stage of the apoptotic pathway in patients with decompensating heart failure who required LVAD support and compared them with patients with less severe heart failure undergoing elective heart transplantation.
|
11568062 |
2001 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the current study, we aimed to investigate the mechanisms by which interleukin 6 induces myocardial failure in meningococcal sepsis and to identify potential novel therapeutic targets.
|
21494108 |
2011 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results exhibited that YQFM significantly mitigated CAL-induced HF via meliorating the left ventricular contractile function and reducing the serum content of creatine kinase MB (CK-MB), aspartate aminotransferase (AST), interleukin-6 (IL-6), troponin (Tn), myosin, myoglobin (MYO) and myocilin (MYOC).
|
31505423 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
The effects of atorvastatin (10 mg) on systemic inflammation in heart failure.
|
16360360 |
2005 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results of the study demonstrated that IL‑6 contributed to the progression of HF via the AT1‑R pathway.
|
28440487 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study examined the individual and combined effect of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), interleukin-6 (IL-6), and hs-CRP on the prediction of heart failure incidence or progression in patients with type 2 diabetes.
|
28684396 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Specific matrix metalloproteinases (MMP-2, MMP-9) and inflammatory biomarkers (hsCRP, IL-6) were found to be consistently up-regulated in severe mitral valve regurgitation (MR) and are associated with mortality in heart failure patients.
|
29663512 |
2018 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The multivariable logistic regression showed that IL-1β [relative ratio (RR) = 1.08, 95% CI: 1.02-1.15, <i>P</i> = 0.010], IL-6 (RR = 1.03, 95% CI: 1.01-1.06, <i>P</i> = 0.016), PTX-3 (RR = 1.31, 95% CI: 1.11-1.55, <i>P</i> = 0.001), and ANGPTL-4 (RR = 1.05, 95% CI: 1.02-1.07, <i>P</i> < 0.001) were independently associated with HF, while IL-6 (RR = 1.03, 95% CI: 1.01-1.04, <i>P</i> = 0.019), PTX-3 (RR = 1.23, 95% CI: 1.06-1.43, <i>P</i> = 0.007), and ANGPTL-4 (RR = 1.03, 95% CI: 1.01-1.06, <i>P</i> = 0.005) were independently associated with the HF subtype.
|
31105751 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
RGD |
This study examined the effects of exercise training (ExT) upon concentration of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) in the gastrocnemius of rats with heart failure (HF) induced by left coronary artery ligation.
|
28939262 |
2018 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together with possible involvement of interleukin-6 in the pathogenesis of heart failure and muscle wasting, inhibition of interleukin-6 receptor signalling by tocilizumab may be a safe and reasonable approach in the treatment of active TA with heart failure and muscle wasting.
|
31297975 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Proinflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor α (TNFα) have long been implicated in cardiovascular risk and considered to be a major underlying cause for heart failure (HF).
|
28763371 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Heart failure due to a variety of causes is accompanied by an upregulation of cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).
|
15135663 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, little is known regarding the association between IL-6 and clinical characteristics, outcomes and other inflammatory biomarkers in HF.
|
31087601 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The three biomarkers were shown to be good predictors of post-STEMI HF (IL-6: AUC 0.786, P=0.002; VCAM-1: AUC 0.797, P=0.001; and ICAM-1: AUC 0.825, P<0.0001), with the respective cutoff points being calculated based on the best sensitivity and specificity indexes (IL-6: 8.67 pg/mL; VCAM-1: 1501.42 ng/mL; and ICAM-1: 1262.38 ng/mL).
|
31778438 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
A total of 559 Danish subjects with severe chronic HF enrolled in the previously reported Echocardiography and Heart Outcome Study were genotyped for three SNPs in IL6, nine in the IL-6 receptor gene (IL6R), and two in the IL-6 signal transducer gene (IL6ST).
|
30651573 |
2019 |