|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Loss of IL-23/IL-17 by genetic deletion of IL-23/p19 in the Ro52(-/-) mice conferred protection from skin disease and systemic autoimmunity.
|
19635858 |
2009 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Overall, we show that MHC presentation and the adaptor functions of 14-3-3ζ participate in promoting IFN-γ and IL-17 production, two of the cytokines commonly associated with autoimmune diseases.
|
31396202 |
2019 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These findings substantiate the functional relevance of the rs2275913 polymorphism and indicate that the higher IL-17 secretion by individuals with the 197A allele likely accounts for their increased risk for acute GVHD and certain autoimmune diseases.
|
22028838 |
2011 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We conclude that a shift in immunodominance of self-antigenic determinants of Col-V results in induction of IFN-γ and IL-17 with loss of tolerance leading to autoimmunity to Col-V, which leads to chronic lung allograft rejection.
|
22132895 |
2012 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Elevated interleukin-17 (IL-17), which is known in autoimmune diseases, has recently been recognized in cancer patients.
|
31432577 |
2019 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Moreover, co-engagement of the TCR and a risk variant of CD226 that is associated with autoimmunity (rs763361) further enhanced VAV1 activation and IL-17 production.
|
29991650 |
2018 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Alleles of IL-17A and IL-17F genes were reported to be associated with many inflammatory and autoimmune disorders in Asian patients.
|
26337284 |
2016 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Although interleukin-17 (IL-17) is a recently discovered cytokine associated with several autoimmune diseases, its role in the pathogenesis of chronic graft-versus-host disease (cGVHD) was not established yet.
|
25136146 |
2014 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Th17 cells are a class of Th cells that secrete IL-17 and mediate pathogenic immunity responsible for autoimmunity including experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis.
|
29794014 |
2018 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Interleukin-17A (IL17A) plays a critical role in the development of numerous autoimmune diseases, including psoriasis.
|
30938974 |
2019 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-17 is a proinflammatory cytokine implicated in the pathogenesis of autoimmune diseases including psoriasis.
|
25024377 |
2014 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease.
|
30214937 |
2018 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-17-producing helper T (Th17) cells are critical for host defense against extracellular pathogens but also drive numerous autoimmune diseases.
|
26511769 |
2015 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
MCs of diabetic NOD mice are overly inflammatory and secrete large amounts of IL-6 that favors differentiation of IL-17-secreting T cells at the site of autoimmunity.
|
26732858 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
<i>δTCR</i><sup>-/-</sup> mice that received <i>IL-17A</i><sup>-/-</sup> γδ T cells demonstrate that the development of anti-MPO autoimmunity and GN are dependent on γδ T cell IL-17A production.
|
28954887 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Interleukin-17 (IL-17)-secreting T helper 17 cells were recently identified as a CD4(+) T helper subset and implicated in various inflammatory and autoimmune diseases.
|
26733204 |
2016 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-17 is a pro-inflammatory cytokine implicated a variety of autoimmune diseases.
|
28765647 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-17 mediates essential inflammatory responses in host defense and autoimmunity.
|
20554964 |
2010 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Here we briefly review the roles of IL-17 in the pathogenesis of selected autoimmune diseases and provide updates on ongoing and recently completed trials of IL-17 based immunotherapies.
|
30765202 |
2019 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Th17 cells, a subset of IL-17-producing T cells distinct from Th1 or Th2 cells has been described as key players in inflammation and autoimmune diseases as well as cancer development.
|
24402773 |
2014 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Kawasaki disease was associated with higher IL-17A and IL-6, a cytokine profile similar to other autoimmune diseases.
|
25585854 |
2015 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
To evaluate the association between development, progression, and response to therapy among patients with immune thrombocytopenia (ITP) and different cytokine gene polymorphisms known to be related to autoimmunity [tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, IL-6, IL-17, IL-1Ra].
|
27007229 |
2016 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Therefore, AS2762900-00 represents a potent novel IL-23-IL-17 pathway inhibitor with the potential to be developed into a new therapy for the treatment of autoimmune diseases.
|
29588152 |
2018 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Although IL-17A and IL-17F share the highest amino acid sequence homology, they perform distinct functions; IL-17A is involved in the development of autoimmunity, inflammation, and tumors, and also plays important roles in the host defenses against bacterial and fungal infections, whereas IL-17F is mainly involved in mucosal host defense mechanisms.
|
21349428 |
2011 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Th17 cell and IL-17-mediated autoimmunity and inflammatory responses have been implicated in the development of organ damage in systemic lupus erythematosus (SLE), and new evidence suggests that hypoxia-inducible factor 1α (HIF-1α) enhances Th17 differentiation and promotes IL-17 production.
|
30043119 |
2018 |