|
Appendicitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Associations with appendicitis were found for SNPs IL-13 rs1800925 with odds ratio (OR) 6.02 (95% CI 1.52-23.78) for T/T versus C/C + T/T, for IL-17 rs2275913 with OR 2.38 (CI 1.24-4.57) for A/A vs G/G + GA, for CCL22 rs223888 with OR 0.12 (0.02-0.90), and for A/A vs G/G + GA. Signs of effect modification of age for the association with appendicitis were found for IL-13 rs1800925 and CTLA4 rs3087243.
|
31845023 |
2020 |
|
Arthritis, Infectious
|
0.010 |
Biomarker
|
group |
BEFREE |
Impact of simultaneous neutralization of IL-17A and treatment with recombinant IL-2 on Th17-Treg cell population in S.aureus induced septic arthritis.
|
31790794 |
2020 |
|
Presenile dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum samples from 242 memory clinic patients with an aMCI (n=88) or AD dementia (n=154) were analyzed for C-reactive protein and for 14 other inflammatory markers [interleukin (IL)-1β, interleukin-1 receptor antagonist, IL-6, IL-10, IL-12p40, IL-17a, IL-18, IL-22, IL-33, tumor necrosis factor, cluster of differentiation 40 ligand, interferon-γ, chemokine ligand (CCL) 2, and CCL4] by bead-based multiplex immunoassay.
|
31414991 |
2020 |
|
Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Keratinocyte-conditioned media of resting, IL-17A-, and/or transforming growth factor-β-primed primary keratinocytes were used to stimulate healthy donors and scleroderma fibroblasts.
|
31276679 |
2020 |
|
Glossitis, Benign Migratory
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunopositivity for the antibodies anti-IL6, anti-IL17, and anti-IL23 revealed cytoplasmic staining, mainly basal and parabasal, in both psoriasis and geographic tongue.
|
31789253 |
2020 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In CSF of HTT gene expansion carriers, we found increased levels of proinflammatory cytokines, including IL-17, and increased consumption of the lymphocyte growth factor IL-7 before motor onset of HD.
|
31725947 |
2020 |
|
Lichen planus follicularis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The number of IL-17A-positive mast cells was significantly higher in the LPP lesions than in normal scalp.
|
30379356 |
2020 |
|
Pseudopelade
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-17-positive mast cell infiltration in the lesional skin of lichen planopilaris: Possible role of mast cells in inducing inflammation and dermal fibrosis in cicatricial alopecia.
|
30379356 |
2020 |
|
hiv-infection/aids
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data indicated that the NF-κB and MAPK pathways are involved in the repair of barrier integrity mediated by IL-17A and IL-17F, and IL-17 pathways are potential targets for gut barrier restoration therapies during HIV/AIDS.
|
30951887 |
2020 |
|
Dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum samples from 242 memory clinic patients with an aMCI (n=88) or AD dementia (n=154) were analyzed for C-reactive protein and for 14 other inflammatory markers [interleukin (IL)-1β, interleukin-1 receptor antagonist, IL-6, IL-10, IL-12p40, IL-17a, IL-18, IL-22, IL-33, tumor necrosis factor, cluster of differentiation 40 ligand, interferon-γ, chemokine ligand (CCL) 2, and CCL4] by bead-based multiplex immunoassay.
|
31414991 |
2020 |
|
Bacterial respiratory infection
|
0.010 |
Biomarker
|
group |
BEFREE |
Recent studies show that Interleukin-17 (IL-17) family cytokines are directly involved in host immune responses against respiratory bacterial infection and in particular, IL-17C is highly induced in bacterial infected respiratory epithelium.
|
31318581 |
2020 |
|
Nephrotoxic serum nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PD1<sup>+</sup>CD4<sup>+</sup> T cell numbers and mRNA levels of IL-17A are elevated in NTN kidneys of TNF TKO mice, suggesting that augmented local Th17 responses in the TNF TKO kidney may exaggerate renal injury and fibrosis.
|
31736350 |
2020 |
|
Papulopustular Rosacea
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesize that IL-17 inhibitors, currently used successfully in psoriasis and psoriatic arthritis, could perhaps be used to treat severe and treatment-resistant papulopustular rosacea in the future; however, clinical trials and case reports will be needed to dictate expanded indications of IL-17 inhibitors.
|
31402691 |
2020 |
|
Arthritis, Bacterial
|
0.010 |
Biomarker
|
group |
BEFREE |
Impact of simultaneous neutralization of IL-17A and treatment with recombinant IL-2 on Th17-Treg cell population in S.aureus induced septic arthritis.
|
31790794 |
2020 |
|
Scarring alopecia
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-17-positive mast cell infiltration in the lesional skin of lichen planopilaris: Possible role of mast cells in inducing inflammation and dermal fibrosis in cicatricial alopecia.
|
30379356 |
2020 |
|
MYOTONIC DYSTROPHY 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Th17 signature in DM patients supports the potential use of IL-17 inhibitors in treatment of IIMs.
|
31292651 |
2020 |
|
Non-radiographic axial spondyloarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to evaluate the efficacy and safety of ixekizumab, an IL-17 inhibitor, in non-radiographic axial spondyloarthritis.
|
31813637 |
2020 |
|
Achondroplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We present a patient with ACH resistant to multiple therapies, including the biologic adalimumab, who was successfully treated with an IL-17 inhibitor (ixekizumab).
|
31184530 |
2019 |
|
Acute alcoholic liver disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data demonstrate that intermediate monocytes are expanded, functionally activated, induce CD4<sup>+</sup> T cell IL-17 expression, and are enriched in the liver of patients with AH.
|
31722987 |
2019 |
|
Anemia, Sickle Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Antibiotic treatment rescued increased intestinal inflammatory cytokine marker genes (Tnfα, IL17, Ifnγ) expression, rescued decreased intestinal barrier marker genes (claudin 3 and claudin 15) expression, and rescued increased serum cytokines (IFNγ, IL27, IL10) in SCD mice.
|
31209247 |
2019 |
|
Aortic Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TLR4, IL-1β, IL-6 and IL-17) were detected in aortic tissues from old control people and AAA cases.
|
31648011 |
2019 |
|
Aortitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-25 enhanced IL-1β and TNF production by IL-25 receptor-expressing dendritic cells and macrophages, respectively, at inflammatory sites of aortae of Il1rn<sup>-/-</sup> mice, contributing to exacerbation of development of IL-1-, TNF- and IL-17A-dependent aortitis in those mice.
|
31745167 |
2019 |
|
Bacteremia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Baseline IL-17A levels were elevated in patients with persistent bacteremia (P < .0001), endovascular (P = .026) and metastatic tissue infections (P = .012).
|
30165412 |
2019 |
|
Benign Ovarian Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we investigated the distribution patterns of γδ T cells and their main subsets in peripheral blood and tumor tissues among OC patients, benign ovarian tumor (BOT) patients, and age-matched healthy controls (HC) by flow cytometry, as well as the expression levels of IFN-γ and IL-17A secreted from γδ T cells.
|
31064389 |
2019 |
|
Blastomycosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We validated differences in cytokine production between Hmong and European volunteers and formally demonstrated a critical role for IL-6 in the development of adaptive immunity to <i>Blastomyces dermatitidis</i> Our findings suggest that the dysregulation of IL-17 responses underlies a recently reported and poorly understood ethnic health disparity.<b>IMPORTANCE</b> Blastomycosis is a potentially life-threatening infection caused by the fungus <i>Blastomyces dermatitidis</i> As with related fungal diseases, blastomycosis is noted to affect some populations more than others.
|
31213563 |
2019 |