INHBA, inhibin subunit beta A, 3624

N. diseases: 83; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023267
Disease: Fibroid Tumor
Fibroid Tumor 		0.300 Biomarker disease CTD_human A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. 22228119 2012
CUI: C0153567
Disease: Uterine Cancer
Uterine Cancer 		0.300 Biomarker disease CTD_human A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. 22228119 2012
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.300 Biomarker disease CTD_human Activin A and follistatin in acute liver failure. 12560755 2003
CUI: C0948216
Disease: Ovarian adenocarcinoma
Ovarian adenocarcinoma 		0.300 GermlineCausalMutation disease ORPHANET Germline mutations of inhibins in early-onset ovarian epithelial tumors. 24302632 2014
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.100 Biomarker disease HPO
CUI: C0021843
Disease: Intestinal Obstruction
Intestinal Obstruction 		0.100 Biomarker disease HPO
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation disease GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764 2015
CUI: C0085606
Disease: Urgency of micturition
Urgency of micturition 		0.100 Biomarker disease HPO
CUI: C0235592
Disease: Cervical lymphadenopathy
Cervical lymphadenopathy 		0.100 Biomarker disease HPO
CUI: C1335168
Disease: Ovarian mucinous tumor
Ovarian mucinous tumor 		0.100 Biomarker disease HPO
CUI: C4024979
Disease: Ovarian papillary adenocarcinoma
Ovarian papillary adenocarcinoma 		0.100 Biomarker disease HPO
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.050 Biomarker disease BEFREE When a representative predictor set of 92 genes was examined, pathways of 'focal adhesion' (with gene components of THBS2, PDGFD, MAPK1, COL1A2, COL6A3), 'ECM-receptor interaction' pathway (THBS2, COL1A2, COL6A3, FN1) and 'TGF-beta signaling' (THBS2, MAPK1, INHBA) represent some of the main differences between normal and tumor of gastric cancer at a molecular level. 17601708 2007
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.050 Biomarker disease BEFREE Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery. 24778035 2014
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.050 Biomarker disease BEFREE On the basis of the observations and findings of this study, INHBA gene silencing inhibited the progression of GC by inactivating the TGF-β signaling pathway, which provides a potential target in the treatment of GC. 30963572 2019
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.050 Biomarker disease BEFREE The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer. 20043075 2010
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.050 AlteredExpression disease BEFREE INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1. 28652421 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.050 Biomarker disease BEFREE Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery. 24778035 2014
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.050 Biomarker disease BEFREE On the basis of the observations and findings of this study, INHBA gene silencing inhibited the progression of GC by inactivating the TGF-β signaling pathway, which provides a potential target in the treatment of GC. 30963572 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.050 AlteredExpression disease BEFREE INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1. 28652421 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.050 Biomarker disease BEFREE When a representative predictor set of 92 genes was examined, pathways of 'focal adhesion' (with gene components of THBS2, PDGFD, MAPK1, COL1A2, COL6A3), 'ECM-receptor interaction' pathway (THBS2, COL1A2, COL6A3, FN1) and 'TGF-beta signaling' (THBS2, MAPK1, INHBA) represent some of the main differences between normal and tumor of gastric cancer at a molecular level. 17601708 2007
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.050 Biomarker disease BEFREE The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer. 20043075 2010
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.020 AlteredExpression disease BEFREE Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis. 16735027 2006
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.020 AlteredExpression disease BEFREE However, there was no difference between these groups in the amount of synovial FRP, suggesting its elevated turnover in RA. 9786430 1998
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.020 AlteredExpression disease BEFREE Differential expression of WNTs and FRPs in the synovium of rheumatoid arthritis and osteoarthritis. 16735027 2006
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.020 AlteredExpression disease BEFREE FRP gene expression was higher in RA than OA synovium (P < 0.05). 9786430 1998