Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of ganciclovir sensitivity by exclusion of thymidine kinase gene from transplanted proinsulin-producing fibroblasts as a gene therapy model for diabetes.
|
8646554 |
1996 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, the results demonstrate that the INS-PLLA PMs have a strong potential as an effective strategy for inhalation treatment of diabetes.
|
30284409 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In genetically obese mice with otherwise wild-type islets, disulfide-linked complexes of proinsulin are more abundant, and leptin receptor-deficient mice, the further increase of such complexes tracks with the onset of islet insulin deficiency and diabetes.
|
31184302 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taking into account that in most cases only a small proportion of islets are infiltrated by amyloid, the limited reduction in proinsulin mRNA is unlikely to play a major role in the pathogenesis of diabetes.
|
11272184 |
2001 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This was associated with diminished glucose-stimulated insulin secretion, increased ROS formation, and accumulation of proinsulin, all characteristics of human diabetes.
|
26997281 |
2016 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three of the patients with an INS mutation were diagnosed with diabetes between 6 and 12 months of age.
|
18662362 |
2008 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly 34% of those with diabetes who were IAA negative were oxPTM-INS positive.
|
26350612 |
2015 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Islet cell antibodies are less predictive of IDDM among unaffected children in the general population than in sibs of children with diabetes. The Childhood Diabetes in Finland Study Group.
|
9773728 |
1998 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin.
|
24281155 |
2014 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that CE prevent insulin-deficient diabetes in male and in female Akita mice using a model of misfolded proinsulin.
|
29972779 |
2018 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Despite evidence from several relatively small studies suggesting that INS-VNTR genotypes are associated with predisposition to type 2 diabetes, reduced beta cell function and measures of adiposity, the present study failed to detect any association with a range of diabetes-related traits.
|
15834700 |
2005 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.
|
24281154 |
2014 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The insulin minisatellite (INS VNTR) has been intensively analyzed due to its associations with diseases including diabetes.
|
12952878 |
2003 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It was hypothesized that the INS gene region provides a common genetic causality for diabetes in Samoyeds and Australian Terriers.
|
31587057 |
2019 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Parental history of hypertension and parental history of diabetes and microvascular complications in insulin-dependent diabetes mellitus: the EURODIAB IDDM Complications Study.
|
9609365 |
1998 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some were initially diagnosed as having IDDM based on an apparent acute onset in youth and the clinical severity of their diabetes.
|
8056189 |
1994 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in the preproinsulin protein that affect processing of preproinsulin to proinsulin or lead to misfolding of proinsulin are associated with diabetes.
|
20034470 |
2010 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IDDM2 diabetes susceptibility locus maps to a minisatellite composed of a variable number of tandem repeats situated 0.5 kb upstream of INS.
|
11502799 |
2001 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that proinsulin B24-C36 peptide binds to I-A(g7), the MHC class II molecule of the NOD mouse, and, after intranasal administration, induces regulatory CD4(+) T cells that, in the absence of CD8(+) T cells, block the adoptive transfer of diabetes.
|
12727928 |
2003 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
One difficulty involved in gene therapy for diabetes is a control of proinsulin production by the cells transfected with insulin cDNA.
|
8889233 |
1997 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We describe the durable correction of streptozotocin-induced murine diabetes by in vivo implantation of primary mouse hepatocytes electroporated ex vivo with a human proinsulin cDNA plasmid construct controlled by glucose and zinc regulatory elements.
|
15703765 |
2005 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In diabetes, insulin secretion is either completely absent (insulin-dependent diabetes mellitus [IDDM]) or inappropriately regulated (non-insulin-dependent diabetes mellitus [NIDDM]).
|
8314006 |
1994 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.
|
29377149 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study of Asian Indian offspring of diabetic parents has shown that genetic predisposition to diabetes resulted in increased proinsulin to insulin ratio at the fasting state.
|
9768375 |
1998 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tolerizing vaccination of NOD mice with a cDNA plasmid expressing full-length proinsulin prevented diabetes, whereas plasmids encoding ZnT8 and DβH did not.
|
27069933 |
2016 |