INS, insulin, 3630

N. diseases: 405; N. variants: 37
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1853490
Disease: 22q13.3 Deletion Syndrome
22q13.3 Deletion Syndrome 		0.300 Therapeutic disease CTD_human Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial. 18948358 2009
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 Biomarker phenotype BEFREE The mechanisms that account for the abnormal behavior of these cells in IDDM are not fully understood. 9519758 1998
CUI: C4280765
Disease: Abnormal C-peptide level
Abnormal C-peptide level 		0.100 Biomarker phenotype HPO
CUI: C1847425
Disease: Abnormal oral glucose tolerance
Abnormal oral glucose tolerance 		0.100 Biomarker phenotype HPO
CUI: C4021753
Disease: Abnormality of the immune system
Abnormality of the immune system 		0.100 Biomarker disease HPO
CUI: C4316903
Disease: Absence Seizures
Absence Seizures 		0.300 Biomarker phenotype CTD_human Trimethoprim-sulfamethoxazole induced prolonged hypoglycemia in an infant with MHC class II deficiency: diazoxide as a treatment option. 14714756 2003
CUI: C4316903
Disease: Absence Seizures
Absence Seizures 		0.300 Biomarker phenotype CTD_human Drug-induced convulsions. Report from Boston Collaborative Drug Surveillance Program. 4115818 1972
CUI: C0000889
Disease: Acanthosis Nigricans
Acanthosis Nigricans 		0.010 Biomarker disease BEFREE For our patients, clinical features are most helpful in differentiating NIDDM-Y from IDDM and include ethnic background, age and gender at diagnosis (approximately 80% of First Nation patients from northern Manitoba are adolescent females), presence of obesity and acanthosis nigricans, lack of symptoms or weight loss, and strong family history of NIDDM. 9492113 1998
CUI: C0702169
Disease: Acrania
Acrania 		0.300 Therapeutic disease CTD_human Arsenate-induced maternal glucose intolerance and neural tube defects in a mouse model. 19446573 2009
CUI: C0001206
Disease: Acromegaly
Acromegaly 		0.010 AlteredExpression disease LHGDN The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients. 17652220 2007
CUI: C0546126
Disease: Acute Confusional Senile Dementia
Acute Confusional Senile Dementia 		0.300 Biomarker disease CTD_human Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? 15750215 2005
CUI: C0546126
Disease: Acute Confusional Senile Dementia
Acute Confusional Senile Dementia 		0.300 Biomarker disease CTD_human Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. 9443474 1998
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.300 Biomarker disease CTD_human Rhabdomyolysis with concurrent atorvastatin and diltiazem. 12243603 2002
CUI: C1565662
Disease: Acute Kidney Insufficiency
Acute Kidney Insufficiency 		0.300 Biomarker disease CTD_human Rhabdomyolysis with concurrent atorvastatin and diltiazem. 12243603 2002
CUI: C0001403
Disease: Addison Disease
Addison Disease 		0.020 Biomarker disease BEFREE To investigate the contribution of INS-VNTR to the genetic susceptibility to autoimmune disorders, we analyzed 102 autoantibody-positive T1DM patients, 59 patients with celiac disease (CD), and 57 patients with Addison's disease (ADD), as well as 111 unrelated healthy individuals from the general population. 14679083 2003
CUI: C0001403
Disease: Addison Disease
Addison Disease 		0.020 Biomarker disease BEFREE Arguments in support of this are: 1) The presence of cellular immune abnormalities in this POF patient group reminiscent of endocrine autoimmune diseases such as IDDM, Graves' disease, and Addison's disease; 2) The more than normal association with IDDM and myasthenia gravis. 9034788 1997
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.010 Biomarker group BEFREE Spontaneously developed gastric adenocarcinomas in Japanese cotton rats and INS-GAS transgenic mice were included. 23389729 2013
CUI: C1332166
Disease: Adenocarcinoma of the gastroesophageal junction
Adenocarcinoma of the gastroesophageal junction 		0.010 GeneticVariation disease BEFREE We selected transcription factor 7-like 2 (TCF7L2) rs7903146 and rs290481, INS rs689 and INSR rs1799817 single-nucleotide polymorphisms (SNPs), and explored the association of these SNPs with lymph node status and risk of AEG. 31211453 2019
CUI: C0001430
Disease: Adenoma
Adenoma 		0.030 AlteredExpression group LHGDN Is there any relation between hyperinsulinemia, insulin resistance and colorectal lesions in patients with acromegaly? 18283256 2008
CUI: C0001430
Disease: Adenoma
Adenoma 		0.030 Biomarker group BEFREE Morphologically 'invisible' proinsulin - secreting adenoma detected by Ga-68 Exendin-4 (GLP-1 Receptor) positron emission tomography/CT. 29399966 2018
CUI: C0001430
Disease: Adenoma
Adenoma 		0.030 AlteredExpression group LHGDN The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients. 17652220 2007
CUI: C0278877
Disease: Adult Meningioma
Adult Meningioma 		0.010 Biomarker disease BEFREE In meningothelial meningiomas, amplification of INS and TCL1A was detected more frequently than in other meningioma subtypes. 15696974 2004
CUI: C0751292
Disease: Age-Related Memory Disorders
Age-Related Memory Disorders 		0.300 Therapeutic group CTD_human Effect of combinations of insulin, glucose and scopolamine on radial arm maze performance. 9264093 1997
CUI: C0001916
Disease: Albinism
Albinism 		0.010 Biomarker disease BEFREE Nystagmus is a disorder of uncontrolled eye movement and can occur as an isolated trait (idiopathic INS, IINS) or as part of multisystem disorders such as albinism, significant visual disorders or neurological disease. 31519934 2019
CUI: C0001925
Disease: Albuminuria
Albuminuria 		0.500 Biomarker phenotype CTD_human Reversible impairment of renal function associated with enalapril in a diabetic patient. 9861226 1998