Hyperglycemia
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Hyperglycemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Proinsulin levels correlated with glucose levels, suggesting that hyperglycemia is the main stimulus for increased proinsulin secretion.
|
7821172 |
1994 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Analysis of blood glucose in diabetic nude mice with transplanted cells showed that proinsulin production by these cells was strongly suppressed by GCV treatment in vivo as reflected by the reversal to hyperglycemia.
|
8646554 |
1996 |
Hyperglycemia
|
0.700 |
Therapeutic
|
disease |
CTD_human |
Iatrogenic neonatal hypertrophic cardiomyopathy.
|
8660453 |
1996 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Iatrogenic neonatal hypertrophic cardiomyopathy.
|
8660453 |
1996 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We hope to emphasize instead the homogeneity of nephropathy risk in both IDDM and NIDDM and also the idea that a common genetic susceptibility exists for all types of diabetes and is conditional on cumulative exposure to hyperglycemia.
|
9649955 |
1998 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Reversible impairment of renal function associated with enalapril in a diabetic patient.
|
9861226 |
1998 |
Hyperglycemia
|
0.700 |
Therapeutic
|
disease |
CTD_human |
Reversible impairment of renal function associated with enalapril in a diabetic patient.
|
9861226 |
1998 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings indicate that elevated proinsulin and proinsulin/insulin ratios are secondary to increased demands on beta-cell secretion induced by hyperglycemia and insulin resistance with no discernible influence of family history of diabetes.
|
11978587 |
2002 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In every patient, fasting insulin, proinsulin, C-peptide and 1,5-anhydro-d-glucitol concentrations were assayed as markers of insulin secretion, peripheral resistance to insulin, and acute hyperglycaemia.
|
17207885 |
2007 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Insulin gene mutations as a cause of permanent neonatal diabetes.
|
17855560 |
2007 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
CTD_mouse |
Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.
|
18056790 |
2008 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
|
18162506 |
2008 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.
|
18192540 |
2008 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that the risk allele of rs7903146 is associated with hyperglycaemia and a higher proinsulin/insulin ratio.
|
19183934 |
2009 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).
|
20226046 |
2010 |
Hyperglycemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Proinsulin levels remained within the normal range (suppressed with hypoglycemia) despite simultaneous almost unmeasurable C-peptide levels during hyperglycemia.
|
23337153 |
2014 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We report a rare case of permanent neonatal diabetes (PND) due to insulin (INS) gene mutation in a 51-month-old girl who presented with hyperglycemia in the neonatal period.
|
23350652 |
2013 |
Hyperglycemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of hProinsulin-B10 in the SMG of chemically induced diabetic mice prevented excessive hyperglycemia observed in untreated mice.
|
23554999 |
2013 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
INS-gene mutations: from genetics and beta cell biology to clinical disease.
|
25542748 |
2015 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this report we present a family with permanent neonatal diabetes, heterozygous for a novel INS gene missense mutation, p.A24V, manifested with marked hyperglycemia and ketoacidosis, unstable glycemic control, requiring insulin therapy, rapid progression of long-term complications and accompanying physical pathological signs and brain lesions.
|
25765664 |
2015 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
They are common causes of MODY (10-60%): persistent incidental childhood hyperglycemia (10-60%) and gestational diabetes mellitus (1-2%).
|
26106223 |
2015 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We report the correction of hyperglycemia of STZ induced diabetic mice using one intravenous systemic administration of a single stranded serotype 8 pseudotyped adeno-associated virus (ssAAV2/8) vector encoding the human proinsulin gene under a constitutive liver specific promoter.
|
26795016 |
2016 |
Hyperglycemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In addition, SMIT1 expression in INS-1E cells and isolated islets was augmented by acute high-glucose exposure and reduced in chronic hyperglycemia conditions.
|
28202581 |
2017 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to conduct an in-depth analysis of pathological changes in retinas from INS <sup>C94Y</sup> pigs exposed to hyperglycaemia for more than 2 years, representing a chronic diabetic condition.
|
28480495 |
2017 |