|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
BEFREE |
Statistical analysis of the results clearly showed that positive staining for phosphorylated insulin receptor was significantly more frequent in adenomas than adenocarcinomas (P < 0.0001) and, within the adenocarcinoma cohort, it was more frequent in low-grade tumors (P = 0.005).
|
25102778 |
2015 |
|
Adenocarcinoma of large intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
Determining the amount of phosphorylated insulin receptor could thus represent a novel prognostic/predictive tool in colorectal adenocarcinoma patients.
|
25102778 |
2015 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Total IR, IR-A, and IR-B expression adversely affects the outcome of cixutumumab in combination with chemotherapy in patient-derived xenograft models of lung adenocarcinoma.
|
26263910 |
2015 |
|
Adenocarcinoma of the gastroesophageal junction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified that TCF7L2 rs290481, INS rs689, and INSR rs1799817 SNPs increased the susceptibility of AEG in different cancer stage subgroups.
|
31211453 |
2019 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Insulin receptor is expressed in normal canine mammary gland and benign adenomas but decreased in metastatic canine mammary carcinomas similar to human breast cancer.
|
21062411 |
2010 |
|
Adenoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We examined the association of circulating levels of IGF-1, IGFBP-3 and IGFBP-1, and SNPs in the IGF-1 receptor (IGF1R), IGF-2 receptor (IGF2R), and insulin receptor genes with risk of adenomas in a sample of 410 incident adenoma cases and 1,070 controls from the Case Transdisciplinary Research on Energetics and Cancer (TREC) Colon Adenomas Study.
|
24194259 |
2014 |
|
Adenoma of large intestine
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Evidence for interaction between INSR variants and BMI and glycemic load for risk of advanced left-sided colorectal adenoma requires independent confirmation, and genotyping of INSR across a broader region and at greater density may be necessary to fully elucidate the nature of these interactions.
|
17416760 |
2007 |
|
Adenoma of large intestine
|
0.020 |
Biomarker
|
disease |
BEFREE |
These epidemiological data motivated us to determine, by means of immunohistochemistry, the amount of activated (phosphorylated) insulin receptor in archival samples from 22 colorectal adenoma and 117 adenocarcinoma patients, with the objective to estimate the role of this factor in colorectal epithelium transformation and cancer progression.
|
25102778 |
2015 |
|
Adipose tissue loss
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Adrenal Gland Pheochromocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tissue-specific modulation of insulin receptor mRNA levels in a patient with a phaeochromocytoma.
|
8252754 |
1993 |
|
Adult Anaplastic Large Cell Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The ALK (anaplastic lymphoma kinase) RTK was originally identified as a member of the insulin receptor subfamily of RTKs that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL (anaplastic large cell lymphoma).
|
19459784 |
2009 |
|
Adult Burkitt Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Insulin receptor expression in Burkitt lymphoma cell lines.
|
2674026 |
1989 |
|
Adult Burkitt Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The Raji cell, another Burkitt lymphoma cell line, also exhibited reduced protein and genetic expression of the insulin receptor, indicating that reduced insulin receptor expression may be representative of other Burkitt lymphoma cell lines.
|
2664477 |
1989 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that activation of the InsR/IGF1R pathway confers resistance to EGFR inhibitors in EGFR-dependent glioblastoma through AKT regulation.
|
26561558 |
2016 |
|
Adult Non-Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Anaplastic Lymphoma Kinase (ALK) was originally identified as a member of the insulin receptor subfamily of receptor tyrosine kinases that acquires transforming capability when truncated and fused to nucleophosmin (NPM) in the t(2;5) chromosomal rearrangement associated with non-Hodgkin's lymphoma, but further insights into its normal structure and function are lacking.
|
9174053 |
1997 |
|
Adult Rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In light of this problem, we developed two resistant models from the rhabdomyosarcoma cell line Rh41: Rh41-807R, with acquired resistance to BMS-754807, a small-molecule dual-kinase inhibitor targeting IGF-IR and insulin receptor (IR), and Rh41-MAB391R, with resistance to MAB391, an IGF-IR-blocking antibody.
|
20807811 |
2010 |
|
Advanced bone age
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
|
30698716 |
2019 |
|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
|
29912962 |
2018 |
|
Allodynia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats.
|
18331706 |
2008 |
|
Alloxan Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Effects of angiotensin II on insulin receptor binding and mRNA levels in normal and diabetic rats.
|
9243097 |
1997 |
|
Alloxan Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis.
|
22138235 |
2012 |
|
Alzheimer Disease, Early Onset
|
0.300 |
Biomarker
|
disease |
CTD_human |
Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin.
|
24055495 |
2014 |
|
Alzheimer Disease, Late Onset
|
0.300 |
Biomarker
|
disease |
CTD_human |
Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin.
|
24055495 |
2014 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The study supports the hypothesis that an impaired control of glycogen synthase kinase-3beta activity by insulin receptor-mediated signalling plays a role in the pathogenesis of AD, facilitating tau protein phosphorylation and neurofibrillary tangle formation.
|
17986027 |
2007 |