|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the role of IR in tumor biology, independent of IGF1R, is less clear.
|
20154728 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The levels of IR were found to be significantly up-regulated during multistep progression from hyperplastic lesions to islet tumors.
|
20457905 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, its expression significantly correlated with (a) the morphological/histopathological subtype of NSCLC, being more frequent in adenocarcinomas; (b) the grade of tumor differentiation, displaying an increase in low-grade carcinomas; (c) tumor size, occurring predominantly in smaller tumors; (d) the presence of phosphorylated, activated insulin receptor; (e) the median patient age, being present in relatively younger individuals.
|
19688775 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Allelic variants of genes encoding components of the insulin pathway, including insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 and insulin receptor substrate-2 (IRS1 and IRS2) have been associated with hyperinsulinemia and insulin resistance and may, therefore, predict susceptibility to colorectal neoplasia.
|
17416760 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we report uniform activation of the insulin receptor (IR) pathway in SFTs, which are mesenchymal tumours frequently associated with hypoglycaemia.
|
17299733 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The hazard risk for metastasis development in stage I/II disease was increased at least 3-fold for tumors with high expression levels of insulin receptor, neurotrophic tyrosine receptor kinase 1, epidermal growth factor receptor, ERBB2, ERBB3, platelet-derived growth factor receptor beta, fibroblast growth factor receptor 1, or leukocyte tyrosine kinase.
|
15753374 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, we demonstrate that the expression of the A isoform of the insulin receptor is significantly upregulated, while that of IGFBP-5 are significantly downregulated in this tumour subtype.
|
15753986 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, all the tumor cell lines examined demonstrated 2- to 4-fold overexpression of the insulin receptor and its signal transduction genes.
|
11062161 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the effect of serum and tumour cyst fluid on autophosphorylation of the insulin receptor was examined.
|
10468998 |
1999 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer.
|
8665514 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The 19p13 breakpoint of one tumor was mapped to a location between the INSR and the TCF3 loci.
|
7504518 |
1993 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression of the insulin receptor gene in these cells may reveal insights into the role of the insulin receptor in tumor biology.
|
1973037 |
1990 |