|
Thymic Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To this end we screened 35 normal and 23 hyperplastic thymuses, 127 thymomas and 41 thymic carcinomas for the presence of sebaceous differentiation as defined by morphology and expression of adipophilin and androgen receptor (AR).
|
31401665 |
2020 |
|
Adrenocortical carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The survival analysis showed that high AR mRNA is associated with poor survival of stomach adenocarcinoma and low-grade glioma, but better survival of adrenocortical carcinoma, kidney renal clear cell carcinoma, acute myeloid leukemia, liver hepatocellular carcinoma, ovarian serous cystadenocarcinoma, and skin cutaneous melanoma based on AR mRNA, protein or AR-score.
|
31759122 |
2020 |
|
Gastric Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The survival analysis showed that high AR mRNA is associated with poor survival of stomach adenocarcinoma and low-grade glioma, but better survival of adrenocortical carcinoma, kidney renal clear cell carcinoma, acute myeloid leukemia, liver hepatocellular carcinoma, ovarian serous cystadenocarcinoma, and skin cutaneous melanoma based on AR mRNA, protein or AR-score.
|
31759122 |
2020 |
|
Ductal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective is to study the following: (a) Expression of AR in resection specimens of ductal carcinomas, (b) Relationship of AR with clinicopathologic features, ER, PR, and Her-2 status.
|
31603099 |
2020 |
|
High Grade Cervical Intraepithelial Neoplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of human papillomavirus (HPV)-vaccine types by race/ethnicity and sociodemographic factors in women with high-grade cervical intraepithelial neoplasia (CIN2/3/AIS), Alameda County, California, United States.
|
31611099 |
2020 |
|
Low grade glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The survival analysis showed that high AR mRNA is associated with poor survival of stomach adenocarcinoma and low-grade glioma, but better survival of adrenocortical carcinoma, kidney renal clear cell carcinoma, acute myeloid leukemia, liver hepatocellular carcinoma, ovarian serous cystadenocarcinoma, and skin cutaneous melanoma based on AR mRNA, protein or AR-score.
|
31759122 |
2020 |
|
Aphasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Seizures are the most frequent cause of mimic, but isolated speech impairment, among adult-onset epilepsy, is quite rare, while aphasia is more often due to an AIS.
|
31213383 |
2019 |
|
Asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data show AR expression is increased in female ASM with asthma, but has retained functionality that could be used to reduce [Ca<sup>2+</sup>]<sub>i</sub> towards alleviating airway hyperresponsiveness.
|
31299143 |
2019 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The AR antagonist darolutamide demonstrated a comparable incidence of cognitive disorder in clinical trials to that of ADT alone.
|
31844181 |
2019 |
|
Common Variable Immunodeficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using the methylation profile of the human androgen receptor (AR) gene as a surrogate epigenetic marker for bone marrow clonality, we examined the hematopoietic compartments of patients with CVID.
|
31341110 |
2019 |
|
Drug abuse
|
0.010 |
Biomarker
|
group |
BEFREE |
For future investigations, it is of importance whether the yeast androgen screen, which has been proven to detect androgenic compounds in urine, can detect an abuse of the selective androgen receptor modulators.
|
30825507 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The approved second-generation androgen receptor (AR) inhibitors enzalutamide and apalutamide were associated with some CNS-related adverse events (AEs) in clinical studies, including fatigue (which can interfere with cognitive function).
|
31844181 |
2019 |
|
Gonadal Dysgenesis, Mixed
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Measurement of AR mRNA expression levels, AR activity [DHT-mediated APOD (apolipoprotein D) induction] and cellular 45,X/46,XY ratios in genital skin fibroblasts from individuals with 45,X/46,XY mosaicism and male reference individuals, and determination of the external virilization scale from individuals with 45,X/46,XY mosaicism.
|
31180485 |
2019 |
|
Chronic granulomatous disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The patient showed an extremely skewed (≥96%) X inactivation pattern of the HUMARA locus; this inactivation is thought to be responsible for the development of CGD not only in neutrophils but also in monocytic, T-cell, and B-cell lineages and in CD34-positive immature hematopoietic cells.
|
30633606 |
2019 |
|
Hyperoxaluria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, results from multiple preclinical studies using multiple in vitro cell lines and in vivo mouse/rat models all demonstrated that targeting the AR with a small molecule ASC-J9® may function via altering macrophage recruitment/M2 polarization to decrease the intrarenal CaOx crystals deposition, a key phenotype seen in many kidney stone disease patients with hyperoxaluria.
|
30894518 |
2019 |
|
Hypotension, Orthostatic
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
<b>Participants</b>: Inpatients who had a C4-T6 SCI (AIS A-D) less than 12 weeks before recruitment, and reported symptoms of OH in their medical chart.
|
31573450 |
2019 |
|
Hypothyroidism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, the study suggests that hypothyroidism could affect male reproductive function by disturbing expression of AR, changing the activity of Ca<sup>2+</sup>-ATPase, inducing oxidative stress and then leading to activation of p38MAPK and JNK signaling in the testicular mitochondria.
|
29896988 |
2019 |
|
Lichen Sclerosus et Atrophicus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Markers of oxidative stress, cell cycle dysregulation and the androgen receptor do not appear to be uniquely associated with lichen sclerosus urethral stricture disease.
|
30835614 |
2019 |
|
Menopausal syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The occurrence of male climacteric syndrome was related to the CAG repeat number of androgen receptor gene, and the male patients with more CAG repeats had higher risk of clinical syndrome of climacteric.
|
30043577 |
2019 |
|
Osteoporosis, Postmenopausal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis.
|
29785666 |
2019 |
|
Ovarian Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hierarchical clustering by PR, ER and AR histoscores identified four EnOC subgroups (PR+/ER+, PR+/ER-, PR-/ER+ and PR-/ER-).
|
31495455 |
2019 |
|
Periodontal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Herein, we investigated the role of androgen receptor and TES on the inflammatory response and alveolar bone resorption associated with ligature-induced periodontal disease in female rats.
|
31389012 |
2019 |
|
Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The blockage of androgen receptor significantly increased radiographic bone loss and tissue levels of IL-1α (P <0.05), IL-1β (P <0.001) and IL-10 (P <0.01) compared with the periodontitis group.
|
31389012 |
2019 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The ARAMIS trial on darolutamide, another AR pathway inhibitor, is also ongoing, and can potentially be another fitting option for M0CRPC.
|
30115959 |
2019 |
|
Vitamin D Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Vascular reactivity showed similar alterations: in females, testosterone constricted the ACA only after combined VDD and hyperandrogenism, whereas in males VDD resulted in increased testosterone-induced contractions in spite of decreased androgen receptor expression.
|
31083690 |
2019 |