|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor (GR) is emerging as a key driver of prostate cancer (PCa) progression and therapy resistance in the absence of androgen receptor (AR) signaling.
|
30305646 |
2018 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, persistent AR signalling undermines therapeutic efficacy and promotes progression to lethal castration-resistant prostate cancer (CRPC), even when patients are treated with potent second-generation AR-targeted therapies abiraterone and enzalutamide.
|
27897170 |
2016 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
To test whether tanshinones inhibit prostate cancer (PCa) growth at least in part through inhibiting androgen receptor (AR) signaling.
|
22281759 |
2012 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
A lncRNA microarray, bioinformatic analysis, and chromatin immunoprecipitation assay were carried out to verify the upstream androgen receptor (AR) signaling pathway.
|
31012142 |
2019 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Androgen receptor (AR) signaling plays a critical role in prostate cancer cell proliferation, survival, and differentiation.
|
25107669 |
2014 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, our data show that androgen receptor (AR) signaling is partially maintained in PP2A-inhibited cells through increased AR expression and ligand-independent phosphorylation.
|
21393425 |
2011 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting androgen receptor (AR) signaling by androgen deprivation therapy (ADT) is the current therapeutic regime for patients newly diagnosed with metastatic PCa.
|
31181727 |
2019 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Initially CRPC remains dependent on androgen receptor (AR) signaling, often through increased expression of full-length AR (ARfl) or expression of dominantly active splice variants such as ARv7.
|
30773341 |
2019 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although second generation endocrine therapies have significantly improved survival, castration-resistant prostate cancer (CRPC) cells are eventually able to escape available hormonal treatments due to reactivation of androgen receptor (AR) signaling.
|
29269934 |
2017 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, the role of BRCA1 in ligand-dependent androgen receptor (AR) signaling was assessed.
|
11085509 |
2000 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
This has prompted research on androgen-mediated androgen receptor (AR) signaling in urothelial cancer.
|
28652170 |
2018 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanism dissection revealed that infiltrating CD4(+) T cells might function through the modulation of FGF11→miRNA-541 signals to suppress PCa androgen receptor (AR) signals.
|
25135278 |
2015 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Novel drugs like Abiraterone or Enzalutamide, which target androgen receptor (AR) signaling to improve androgen deprivation therapy (ADT), have been developed during the past years.
|
26257066 |
2016 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prostate cancer cells demonstrate a remarkable "addiction" to androgen receptor (AR) signaling in all stages of disease progression.
|
27174161 |
2017 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The androgen receptor (AR) signaling axis plays a pivotal role in the progression of prostate cancer.
|
31239713 |
2019 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Androgen receptor (AR) signaling plays a critical role in the development and progression of prostate cancer.
|
19737972 |
2009 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Androgen receptor (AR) signaling pathways are important for the survival and proliferation of prostate cancer cells.
|
17483314 |
2007 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Androgen receptor (AR) signaling is a key driver of prostate cancer, and androgen-deprivation therapy (ADT) is a standard treatment for patients with advanced and metastatic disease.
|
28916652 |
2017 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
The androgen receptor (AR) signalling pathway is known to play an important role in PCa and its blockade constitutes a commonly used treatment modality.
|
23171135 |
2012 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is increasing evidence that sensitization of the androgen receptor (AR) signaling pathway contributes to the failure of androgen ablation therapy for prostate cancer, and that direct targeting of the AR may be a useful therapeutic approach.
|
16423882 |
2006 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
A subset of castration resistant prostate cancers become androgen receptor (AR) signaling-independent and develop neuroendocrine prostate cancer (NEPC) features through lineage plasticity.
|
31260412 |
2019 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite the known importance of androgen receptor (AR) signaling in prostate cancer, the processes downstream of AR that drive disease development and progression remain poorly understood.
|
28507054 |
2017 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reactivation of androgen receptor (AR) signaling partly contributes to the emergence of CRPC.
|
26152593 |
2015 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate genes involved in androgen receptor (AR) signaling as candidate genes for polycystic ovary syndrome (PCOS).
|
26493122 |
2016 |
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Androgen receptor (AR) signaling is essential for prostate cancer (PCa) development in humans.
|
23449888 |
2013 |