|
Acute Cerebrovascular Accidents
|
0.300 |
Biomarker
|
disease |
CTD_human |
Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators.
|
9445356 |
1998 |
|
Corneal Neovascularization
|
0.200 |
Biomarker
|
disease |
RGD |
Inhibition of corneal neovascularization by alpha(v)-integrin antagonists in the rat.
|
10664059 |
2000 |
|
Coronary Stenosis
|
0.200 |
Biomarker
|
disease |
RGD |
Vitronectin is up-regulated after vascular injury and vitronectin blockade prevents neointima formation.
|
11922905 |
2002 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets.
|
18211678 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although both platelet endothelial cell adhesion molecule-1 and L1 are known to bind integrin alpha(v)beta(3), only L1 serves as a potential ligand for alpha(v)beta(3) during melanoma transendothelial migration.
|
11553709 |
2001 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The integrin alpha(v)beta(3)-expressing melanoma lines Mel57 and Zkr nearly exclusively produced metastases in the brain parenchyma, whereas cells of the BLM and MV3 lines, devoid of integrin alpha(v)beta(3) expression, preferentially metastasized to dura mater and leptomeninges.
|
11291042 |
2001 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although p53 is not frequently mutated in melanoma, it is inactivated by integrin αv-mediated signaling, as we previously demonstrated 1, which may account, at least partially, for increased apoptosis resistance of malignant melanoma.
|
21239882 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased activity of the proto-oncogene c-Src and elevated levels of integrin alpha(v)beta(3) are found in melanomas and multiple carcinomas.
|
17363590 |
2007 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
CEACAM1 enhances invasion and migration of melanocytic and melanoma cells.
|
15509546 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was determined that miR-146a coordinated melanoma cell growth by its direct targets lunatic fringe (LFNG) and NUMB, which operate on the NOTCH/PTEN/Akt pathway; while inhibition of metastasis formation was linked to decreased expression of ITGAV and ROCK1.
|
27311960 |
2016 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The level of integrin alpha(v)beta3 and its ligand osteopontin (OPN) has been directly correlated to tumorigenicity of melanoma and other cancer cells.
|
16631740 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Even though integrin alpha v beta 3 is thought to play a role in invasive growth of melanomas, some metastatic melanoma cell lines lack alpha v beta 3, and downmodulation of alpha v beta 3, expression can enhance the invasive capacity of certain melanoma cells.
|
8806594 |
1996 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
alpha v beta3-dependent cross-presentation of matrix metalloproteinase-2 by melanoma cells gives rise to a new tumor antigen.
|
15998788 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis showed a similar tissue distribution in humans for the antigen recognized by anti-OFA antibodies, a monoclonal antibody, LM142, raised to melanoma VNR, polyclonal antibodies to the placental VNR and a monoclonal antibody to the presumptive VNR beta chain, platelet glycoprotein 111a.
|
2477382 |
1989 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, integrin alpha v gene expression and the resulting adhesive phenotype are directly involved in the proliferation of human melanoma in vivo.
|
1376331 |
1992 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results suggest that expression of integrin alpha v beta 3 promotes the metastatic phenotype in human melanoma by supporting specific adhesive, invasive and migratory properties of the tumor cells and that the related integrin alpha IIb beta 3 cannot substitute for alpha v beta 3 in this respect.
|
12198771 |
2002 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
We tested whether integrin alpha v beta 3 supports metastasis of human melanoma cells when injected into the bloodstream of immune deficient mice.
|
12198771 |
2002 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Melanoma survival and growth in three-dimensional microenvironments requires the expression of integrin αv, which acts to suppress p53 activity.
|
22773839 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, some host cytokines may preferentially induce melanoma cells to express ICAM-1 (which can increase host cytotoxic response against melanoma), other than the VnR (which instead might contribute to melanoma metastasis).
|
8869681 |
1996 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The finding that integrin alpha(v)beta1 is involved in Ad5 infection has implications for the use of recombinant Ad5 vectors for cancer gene therapy, since alpha(v)beta1 is expressed at high levels and acts as an alternative vitronectin receptor in many epithelial and some melanoma tumours which express no alpha(v)beta3 and constant low levels of alpha(v)beta5.
|
11778901 |
2002 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium.
|
15897908 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen.
|
15557124 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
We have previously shown an increase in pp(60c-Src) kinase activity associated with integrin alpha(v)beta3 in melanoma cells (M21) treated with soluble OPN. pp(60c-Src) kinase activity was not observed in melanoma cells expressing alpha(v) that lacks the cytoplasmic domain (alpha(v)995).
|
16631740 |
2006 |
|
Glioblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
As we have found that Lyn, but not Fyn, activity promotes migration of glioblastoma cells in response to the cooperative signal generated by platelet-derived growth factor receptor beta and integrin alpha(v)beta3, we compared the activity and expression of Lyn and Fyn in glioblastoma (grade IV) tumor biopsy samples with that in anaplastic astrocytoma (grade III) tumors, nonneoplastic brain, and normal autopsy brain samples.
|
15994925 |
2005 |
|
Glioblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Alpha Particle Enhanced Blood Brain/Tumor Barrier Permeabilization in Glioblastomas Using Integrin Alpha-v Beta-3-Targeted Liposomes.
|
28619756 |
2017 |