Periventricular Nodular Heterotopia
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the BIG2 Arf1 GEF have been linked to autosomal recessive periventricular heterotopia, a disorder of neuronal migration that leads to severe malformation of the cerebral cortex.
|
19669794 |
2009 |
Periventricular Nodular Heterotopia
|
0.410 |
GermlineCausalMutation
|
disease |
ORPHANET |
Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation.
|
28868155 |
2016 |
Periventricular Nodular Heterotopia
|
0.410 |
Biomarker
|
disease |
HPO |
|
|
|
PERIVENTRICULAR NODULAR HETEROTOPIA 8
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation.
|
28868155 |
2016 |
PERIVENTRICULAR NODULAR HETEROTOPIA 8
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
CTD_human |
These findings underline the importance of ARF1 in promoting metastasis and suggest that LM11 that inhibits ARF1 activation may represent a potential therapeutic approach to prevent or treat breast cancer metastasis.
|
27517156 |
2016 |
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
These findings underline the importance of ARF1 in promoting metastasis and suggest that LM11 that inhibits ARF1 activation may represent a potential therapeutic approach to prevent or treat breast cancer metastasis.
|
27517156 |
2016 |
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
In conclusion, this study provides a new mechanism by which ARF1 regulates cell migration and identifies this GTPase as a promising pharmacological target to reduce metastasis formation in breast cancer patients.
|
23707487 |
2013 |
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
CTD_human |
These findings underline the importance of ARF1 in promoting metastasis and suggest that LM11 that inhibits ARF1 activation may represent a potential therapeutic approach to prevent or treat breast cancer metastasis.
|
27517156 |
2016 |
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
In conclusion, this study provides a new mechanism by which ARF1 regulates cell migration and identifies this GTPase as a promising pharmacological target to reduce metastasis formation in breast cancer patients.
|
23707487 |
2013 |
Breast Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
These findings underline the importance of ARF1 in promoting metastasis and suggest that LM11 that inhibits ARF1 activation may represent a potential therapeutic approach to prevent or treat breast cancer metastasis.
|
27517156 |
2016 |
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1.
|
27517156 |
2016 |
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1.
|
27517156 |
2016 |
Aortic Aneurysm
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Aortic Valve Insufficiency
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Patent ductus arteriosus
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Gastroesophageal reflux disease
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Scoliosis, unspecified
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.
|
31417091 |
2019 |
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese.
|
31417091 |
2019 |
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA TP73-AS1 is a novel regulator in cervical cancer via miR-329-3p/ARF1 axis.
|
31232491 |
2020 |
Glioblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Finally, we found that EGFR gene amplifications were associated with distinct tumor infiltration patterns, thus representing a putative novel functional association between EGFR gene amplification and ARF1 gene promoter methylation in GB.
|
28631186 |
2017 |
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent reports indicate that the replication of hepatitis C virus (HCV) depends on the GBF1-Arf1-COP-I pathway.
|
24058576 |
2013 |
Creutzfeldt-Jakob disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also examined Arf1 expression in the brain of CJD patients with the subtypes MM1 and VV2 and found that it was regulated in a region-specific manner.
|
25896910 |
2015 |