KRT10, keratin 10, 3858

N. diseases: 93; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006625
Disease: Cachexia
Cachexia
0.010 Biomarker phenotype BEFREE In addition, KPP muscles exhibit a similar gene ontology as cachectic patients. 31390573 2019
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus
0.010 Biomarker disease BEFREE Because pancreatic ductal adenocarcinoma (PDA) presents with a high incidence of cachexia, we engineered a mouse model of PDA that we named KPP. 31390573 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 Biomarker phenotype BEFREE Higher CK19 and lower CK 10, 14, 16 scores were associated with distant metastasis. 30579132 2019
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.010 Biomarker disease BEFREE We found a reduced percentage of cells positive for the early differentiation marker cytokeratin 10 and a greater fraction of CD29<sup>+</sup> and involucrin<sup>+</sup> cells in the psoriasis KCs than in nonlesional KCs. 30684548 2019
CUI: C1335302
Disease: Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma
0.010 Biomarker disease BEFREE Because pancreatic ductal adenocarcinoma (PDA) presents with a high incidence of cachexia, we engineered a mouse model of PDA that we named KPP. 31390573 2019
CUI: C1391732
Disease: Cancer cachexia
Cancer cachexia
0.010 Biomarker disease BEFREE We envision that the KPP model will be a useful resource for advancing our mechanistic understanding and ability to treat cancer cachexia. 31390573 2019
CUI: C1561989
Disease: Limbal stem cell deficiency
Limbal stem cell deficiency
0.010 Biomarker disease BEFREE While partial LSCD (CK19 + and/or CK10+, CK3+) was seen in 8% of human and 50% of animal specimens. 31095932 2019
CUI: C4282128
Disease: PATENT DUCTUS ARTERIOSUS 1
PATENT DUCTUS ARTERIOSUS 1
0.010 Biomarker disease BEFREE Because pancreatic ductal adenocarcinoma (PDA) presents with a high incidence of cachexia, we engineered a mouse model of PDA that we named KPP. 31390573 2019
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.010 Biomarker group BEFREE Anti-K10 antibodies are sufficient to mediate RP-like ischemia in murine models and are implicated in the pathogenesis of RP in patients with anti-RNP autoimmunity. 29569858 2018
CUI: C0030193
Disease: Pain
Pain
0.010 Biomarker phenotype BEFREE A 14-item, PD-specific, patient-based questionnaire (the King's Parkinson's Disease Pain Questionnaire, KPPQ) was designed corresponding to the rater-based KPP Scale (KPPS). 29806962 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.010 Biomarker disease BEFREE A 14-item, PD-specific, patient-based questionnaire (the King's Parkinson's Disease Pain Questionnaire, KPPQ) was designed corresponding to the rater-based KPP Scale (KPPS). 29806962 2018
CUI: C0034735
Disease: Raynaud Phenomenon
Raynaud Phenomenon
0.010 Biomarker disease BEFREE Anti-K10 antibodies are sufficient to mediate RP-like ischemia in murine models and are implicated in the pathogenesis of RP in patients with anti-RNP autoimmunity. 29569858 2018
CUI: C0162810
Disease: Cicatrix, Hypertrophic
Cicatrix, Hypertrophic
0.010 AlteredExpression disease BEFREE Moreover, immunohistochemical analysis indicated that Shikonin inhibited the expression of p63, cytokeratin 10, alpha-smooth muscle actin, transforming growth factor-beta 1, and collagen I, which play important roles in hypertrophic scar formation. 29922164 2018
Intraepithelial Squamous Cell Carcinoma
0.010 AlteredExpression disease BEFREE Using arsenic-induced Bowen's disease (As-BD; an intraepidermal carcinoma) as a disease model, we found that in As-BD, the expression of proliferating basal keratinocytes marker cytokeratin 14 (CK14) and N-terminal truncated p63 isoform (ΔNp63; proliferation regulator) was increased, however, that of the differentiation marker cytokeratin 10 (CK10) and full-length p63 isoform (TAp63; differentiation regulator) was decreased in squamous cells as compared with healthy subjects. 30026126 2018
CUI: C0424605
Disease: Developmental delay (disorder)
Developmental delay (disorder)
0.010 AlteredExpression phenotype BEFREE Epithelial developmental delay and low levels of KRT10 were observed in new-born Col4a6-knockout mice. 29422532 2018
CUI: C0432307
Disease: Ichthyosis hystrix of Curth-Macklin
Ichthyosis hystrix of Curth-Macklin
0.010 Biomarker disease BEFREE Role of the keratin 1 and keratin 10 tails in the pathogenesis of ichthyosis hystrix of Curth Macklin. 29689068 2018
CUI: C0557874
Disease: Global developmental delay
Global developmental delay
0.010 AlteredExpression disease BEFREE Epithelial developmental delay and low levels of KRT10 were observed in new-born Col4a6-knockout mice. 29422532 2018
CUI: C0021400
Disease: Influenza
Influenza
0.010 Biomarker disease BEFREE In this study, we first showed that the PA protein of the highly pathogenic avian influenza virus strain CK10 had the strongest inhibitory effect on NF-κB activation when compared with other genes, and that it acted in a dose independent-manner. 28744591 2017
CUI: C0023532
Disease: Leukoplakia, Oral
Leukoplakia, Oral
0.010 Biomarker disease BEFREE Oral leukoplakia tissues were submitted to immunohistochemistry analysis for keratin 10 (CK10). 27478070 2017
CUI: C0079584
Disease: Ichthyosis Vulgaris
Ichthyosis Vulgaris
0.010 Biomarker disease BEFREE Expression of keratin 10 (K10), K14, K16, involucrin, filaggrin, Ki-67, and Melan-A was detected by immunohistochemistry in eight patients with SAK, seven patients with ichthyosis vulgaris (IV) and six healthy controls (HCs). 28543665 2017
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma
0.010 Biomarker disease BEFREE Screening and identification of the tumor-associated antigen CK10, a novel potential liver cancer marker. 28469975 2017
Liver and Intrahepatic Biliary Tract Carcinoma
0.010 Biomarker disease BEFREE Screening and identification of the tumor-associated antigen CK10, a novel potential liver cancer marker. 28469975 2017
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.010 Biomarker disease BEFREE Screening and identification of the tumor-associated antigen CK10, a novel potential liver cancer marker. 28469975 2017
CUI: C0917796
Disease: Optic Atrophy, Hereditary, Leber
Optic Atrophy, Hereditary, Leber
0.010 GeneticVariation disease BEFREE Coexistence of mutations in keratin 10 (KRT10) and the mitochondrial genome in a patient with ichthyosis with confetti and Leber's hereditary optic neuropathy. 28944608 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.010 Biomarker phenotype BEFREE This generalized F-KPP equation with (nonlinear) frequency-dependent diffusion and advection terms admits traveling wave solutions that characterize the invasion of the dominant genotype. 28008475 2017