|
Primary peritoneal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we clarified the prognostic impact of these drug-sensitivity markers in PPC by performing immunohistochemical and clinicopathologic analyses of samples from 105 patients with surgically resected PPC in order to evaluate levels of vascular endothelial growth factor 2 (VEGFR2), stathmin 1 (STMN1), tubulin β3 class III (TUBB3), thymidylate synthetase (TS), topoisomerase II (Topo-II), glucose-regulated protein, and 78 kDa (GRP78)/binding immunoglobulin protein (BiP).
|
31653009 |
2019 |
|
Progressive cGVHD
|
0.010 |
Biomarker
|
disease |
BEFREE |
High percentage of CD8<sup>+</sup> tumor-infiltrating cells (TIC) that are PD-1<sup>+</sup>TIM-3<sup>-</sup>LAG-3<sup>-</sup> (% CD8<sup>+</sup>PD-1<sup>+</sup>TIM-3<sup>-</sup>LAG-3<sup>-</sup> TIC) correlated with high levels of T-cell activation and was associated with longer median irPFS and higher irORR.
|
30670497 |
2019 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
So, this study was designed to elucidate the function of Stathmin gene in the tumorigenesis and progression of glioblastoma cells.
|
29880026 |
2018 |
|
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data reveal differences in functional connectivity between FLR and those eligible for clozapine and suggest that greater connectivity between the SMN and precuneus may be indicative of treatment resistance in people with schizophrenia.
|
29650266 |
2018 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
So, this study was designed to elucidate the function of Stathmin gene in the tumorigenesis and progression of glioblastoma cells.
|
29880026 |
2018 |
|
Chondroblastic osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High tumor expression of STMN1 was a prognostic marker in patients with osteosarcoma for poor prognosis (P=0.016), poor response to chemotherapy (P=0.004), the presence of metastases (P=0.003), advanced Enneking surgical stage (P=0.014), and the chondroblastic osteosarcoma subtype (P=0.004).
|
30169496 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
So, this study was designed to elucidate the function of Stathmin gene in the tumorigenesis and progression of glioblastoma cells.
|
29880026 |
2018 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found expression of Stathmin 1 and p-Stathmin 1<sup>S38</sup> indicates poor survival in HNSCC and may be associated with immune suppression.
|
29847156 |
2018 |
|
IMMUNE SUPPRESSION
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Expression and phosphorylation of Stathmin 1 indicate poor survival in head and neck squamous cell carcinoma and associate with immune suppression.
|
29847156 |
2018 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rescue of STMN1 could partly reverse the effect of miR-770 in TNBC behaviors.
|
29323124 |
2018 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rescue of STMN1 could partly reverse the effect of miR-770 in TNBC behaviors.
|
29323124 |
2018 |
|
Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
To characterize PCFL and PCMZL more clearly and to define criteria helpful for the differential diagnosis, we compared expression of immunohistochemical markers [LIM-only transcription factor 2 (LMO2), human germinal centre-associated lymphoma (HGAL), stathmin 1 (STMN1), activation-induced cytidine deaminase (AID), myeloid cell nuclear differentiation antigen (MNDA)] and the presence of cytogenetic abnormalities described previously in nodal follicular lymphoma [B cell lymphoma 2 (BCL2) and BCL6 breaks, 1p36 chromosomal region deletion (del 1p36)] in a series of 48 cutaneous follicular and marginal zone lymphomas [cutaneous follicular lymphoma (CFL) and cutaneous marginal zone lymphoma (CMZL)].
|
28594133 |
2017 |
|
Chronic osteomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Deregulation of histone methylation mediated the increase of LAG-3<sup>+</sup> T cells during chronic osteomyelitis.
|
28028751 |
2017 |
|
Male infertility
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Aberrant expression or localization of SMN has been also implicated in other pathological conditions, including male infertility, inclusion body myositis, amyotrophic lateral sclerosis and osteoarthritis.
|
29187847 |
2017 |
|
Marijuana Abuse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Standardized <i>Cannabis sativa</i> extract attenuates tau and stathmin gene expression in the melanoma cell line.
|
29147495 |
2017 |
|
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Regulation of the expression and function of target proteins, stathmin, dihydrofolate reductase and pyruvate dehydrogenase E1β, may be potential, therapeutic strategies to effectively treat multiple myeloma.
|
28259901 |
2017 |
|
Prader-Willi Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
SNRPN, which codes for the RNA-binding SmN protein, is a candidate gene for Prader-Willi syndrome.
|
28387446 |
2017 |
|
Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It was further revealed that high Stathmin expression was associated with the repression of staurosporine-induced apoptosis in the cholangiocarcinoma cell.
|
28178656 |
2017 |
|
Adult Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, increased Stathmin expression was correlated to higher meningioma grade and shorter disease-free survival (DFS) of meningioma patients with Simpson I resection.
|
28625575 |
2017 |
|
Squamous cell carcinoma of the hypopharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that STMN1 plays an important role in proliferation and migration of HSCC and may be used as a potential prognostic biomarker or therapeutic target of HSCC.
|
27878293 |
2017 |
|
Benign Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also found expression of Stathmin that atypical/anaplastic meningiomas have higher expression than benign meningiomas (p<0.01).
|
28625575 |
2017 |
|
Atypical meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Kaplan-Meier analysis revealed that STMN1 expression pattern could effectively predict prognosis of atypical meningioma in patients (p<0.01).
|
28622584 |
2017 |
|
Secondary malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, stathmin suppression in neuroblastoma cells significantly reduced whole body, lung, kidney and liver metastases in an experimental metastases mouse model.
|
27321182 |
2017 |
|
Adult Atypical Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Kaplan-Meier analysis revealed that STMN1 expression pattern could effectively predict prognosis of atypical meningioma in patients (p<0.01).
|
28622584 |
2017 |
|
Cutaneous Follicular Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunostaining for STMN1, LMO2, HGAL and AID allowed the distinction between CFL and CMZL, and STMN1 was the most sensitive marker (100% CFL, 0% CMZL).
|
28594133 |
2017 |