LDLR, low density lipoprotein receptor, 3949

N. diseases: 336; N. variants: 1434
Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.100 Biomarker disease BEFREE The low-density lipoprotein receptor (LDLR) has been proposed as a candidate receptor for the hepatitis C virus (HCV). 16871569 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.100 AlteredExpression disease BEFREE CD81 and LDLR were shown to mediate HCV E2-induced activation of ERK and p38 MAPK. 16793913 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.100 Biomarker disease LHGDN In conclusion, this study is the first to support a role for LDLR in the natural infection by HCV in man. 16907851 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.100 GeneticVariation disease BEFREE The Ava II polymorphism at the LDL-R gene exon 13 locus showed a statistically significant difference between chronic HCV-infected patients and healthy controls, indicating a significant contribution of the Ava II polymorphism in susceptibility to HCV infection in these patients. 16927291 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.100 GeneticVariation disease BEFREE We therefore studied genetic variation within the LDLR gene and clinical features of hepatitis C infection. 12209363 2002
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.100 AlteredExpression disease BEFREE A stabilizing effect on HCV propagation was observed for 50 days in a serum-free medium with stimulation of the low-density lipoprotein (LDL) receptor expression by lovastatin. 9349466 1997