Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Northern blot analyses demonstrated leptin mRNA in several breast cancer cell lines (MCF-7, T47D, and MDA-MB-231), a normal breast epithelial cell line (MCF10A), and four breast tumors.
|
10364481 |
1999 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Leptin expression in colorectal and breast cancer patients.
|
10719061 |
2000 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of estrogen on leptin gene promoter activation in MCF-7 breast cancer and JEG-3 choriocarcinoma cells: selective regulation via estrogen receptors alpha and beta.
|
11369444 |
2001 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we demonstrate that leptin receptors are expressed in breast cancer and that leptin induces proliferation in the T47-D cell line via activation of the MAPKinases pathway.
|
11911959 |
2002 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, we have examined the possible link that exists between leptin and breast cancer, focusing our attention on the direct effect of leptin on aromatase activity, which may enhance estrogen production and induce tumor cell growth stimulation.
|
12734209 |
2003 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adipose tissue is a major source of leptin, a cytokine regulating energy balance and controlling different processes in peripheral tissues, including breast cancer cell growth.
|
15475434 |
2004 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Adipocyte expression and circulating levels of leptin increase in both gynaecological and breast cancer patients.
|
15138597 |
2004 |
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Leptin and obesity are clearly related, and obesity is associated with an increased risk of breast cancer.
|
16609020 |
2006 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Higher levels of circulating leptin contribute to breast cancer proliferation by activation of the MAPK and PI3K signaling pathways involved in cell growth and survival.
|
16525650 |
2006 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate that it is difficult to explain breast cancer on the basis of serum leptin concentrations or polymorphisms in the LEPR gene.
|
16011872 |
2006 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of both leptin and its OB-Rb receptor was detected in human breast cancer ZR-75-1 cells and further induced by leptin, suggesting that both expression and message mediation of leptin were autoregulated by itself.
|
16752079 |
2006 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lep-R(L), Lep-R(S) and leptin mRNA levels in breast cancer tissue (n = 91) were determined with a real-time PCR assay, and serum leptin levels in breast cancer patients (n = 67) with an enzyme-linked immunosorbent assay.
|
16206269 |
2006 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The effects of insulin, IGF-I, estradiol, and hypoxia on leptin and ObR mRNA expression were assessed by reverse transcription-PCR in MCF-7 and MDA-MB-231 breast cancer cell lines.
|
16533767 |
2006 |
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results indicated that the polymorphisms in LEP and LEPR genes are associated with increased breast cancer risk as well as disease progress, supporting our hypothesis for leptin involvement in cancer pathogenesis.
|
16504019 |
2006 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Patients with breast cancer had a higher mean serum leptin concentration than women in the control group, but the difference was not statistically significant.
|
18004080 |
2007 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression.
|
17409452 |
2007 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of leptin and ObR in breast cancer tissues was detected by immunohistochemistry (IHC).
|
18945363 |
2008 |
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
And, it also suggested that LEPR gene Gln223Arg polymorphisms, elevated leptin, insulin, TG, FCH, APOA1, WHR, and reduced APOB should play a major role in the development of breast cancer.
|
18668212 |
2008 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that the leptin system might play an important role in breast cancer pathogenesis and progression, and that it might represent a novel target for therapeutic intervention in breast cancer.
|
18821585 |
2008 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha.
|
17653093 |
2008 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, our data suggest that hyperinsulinemia could induce breast cancer progression through leptin-dependent mechanisms.
|
18559540 |
2008 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor.
|
19047149 |
2008 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both leptin and leptin receptor have recently been implicated in processes leading to breast cancer initiation and progression in animal models and humans.
|
19017403 |
2008 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Toward better defining the role of leptin in breast cancer, we describe the identification of leptin-regulated genes in hormone-responsive Michigan Cancer Foundation-7 (MCF-7) human breast cancer cells using a microarray system.
|
18715880 |
2008 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leptin augments proliferation of breast cancer cells via transactivation of HER2.
|
18262553 |
2008 |