|
Hyperinsulinism
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome.
|
15533361 |
2004 |
|
Hyperinsulinism
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analyses showed that factors associated with breast cancer were BMI [OR (95% CI) =2.8 (1.4-5.5), P=0.004]; high levels of adiponectin [5.1 (2.2-11.5), P<0.001); hyperinsulinaemia [1.1 (1.0-1.1), P=0.01], leptin [3.1 (1.7-5.7), P<0.0001], estradiol [2.5 (1.3-4.7), P=0.005] and testosterone [1.3 (1.03-1.7), P=0.03].
|
22664497 |
2012 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
The nocturnal rise of leptin secretion is entrained to mealtime probably due to cumulative hyperinsulinemia of the entire day.
|
9529971 |
1998 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results identify a novel molecular pathway by which leptin confers inhibitory action on insulin secretion, and impaired PP-1 inhibition by leptin may be involved in dysfunction of the adipoinsular axis during the development of hyperinsulinemia and type 2 diabetes mellitus.
|
21427225 |
2011 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
CTD_human |
Insulin depletion leads to adipose-specific cell death in obese but not lean mice.
|
9826672 |
1998 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
RGD |
Creation and preliminary characterization of a leptin knockout rat.
|
22948215 |
2012 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
To investigate the role of chronic hyperinsulinemia in the regulation of plasma leptin concentrations, we studied 13 patients with surgically confirmed insulinoma before and after tumor removal, along with 15 healthy control subjects matched for sex, age, and BMI.
|
9753302 |
1998 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that targeted POMC gene delivery in the hypothalamus suppresses food intake and weight gain and reduces visceral adiposity and hyperinsulinemia in leptin-resistant obese Zucker rats.
|
12882910 |
2003 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin induces angiogenesis and is elevated in obesity and hyperinsulinemia.
|
12411472 |
2002 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
In summary, our data suggest that hyperinsulinemia could induce breast cancer progression through leptin-dependent mechanisms.
|
18559540 |
2008 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Women with polycystic ovaries on ultrasound have increased insulin sensitivity and possible leptin resistance, which could predispose to future weight gain.
|
11678825 |
2001 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
To that end, we conducted a double-blind, placebo-controlled study of the effects of metformin on body mass index (BMI), serum leptin, glucose tolerance, and serum lipids in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes.
|
11335776 |
2001 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Furthermore, hormones that affect energy homeostasis also affect sleep/wake states: the orexigenic hormone ghrelin promotes wakefulness, and the anorexigenic hormones leptin and insulin increase the duration of slow-wave sleep.
|
30471995 |
2018 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
We suggest that dysregulation of the adipoinsular axis in obese individuals due to defective leptin reception by beta-cells may result in chronic hyperinsulinemia and may contribute to the pathogenesis of adipogenic diabetes.
|
10022436 |
1999 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Deficiency of leptin or its receptor produces hyperinsulinemia with marked obesity.
|
11516999 |
2001 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin resistance in obese individuals is frequently associated with insulin resistance and pronounced hyperinsulinaemia indicating a negative crosstalk of the insulin and leptin signalling chain.
|
11596667 |
2001 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
If leptin and insulin sensitivities increase concurrently, the combined effect could be a decrease in fat mass, consistent with the fact that increasing insulin sensitivity is often associated with fat mass loss in trials.
|
31626814 |
2020 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
The short-term isoglycemic hyperinsulinemia (protocol B) had no additional effect on the postdexamethasone leptin response.
|
9360558 |
1997 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Further, we document here the efficacy of leptin replenishment in vivo, especially by supplying it to the hypothalamus with the aid of gene therapy, in preventing the antecedent pathophysiological sequalae--hyperinsulinemia, insulin resistance and hyperglycemia--in various animal models and clinical paradigms of diabetes type 1 and 2 with or without attendant obesity.
|
19647774 |
2009 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
A constellation of loss of satiety and a reduction of the metabolic rate, thermogenesis, and physical activity as well as increased vagal tone and hyperinsulinism with insulin and leptin resistance results in rapid weight gain due to a decreased energy expenditure and increased energy storage in adipose cells.
|
30884480 |
2019 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Analyses of metabolic parameters in maternal venous and umbilical venous plasma revealed significantly increased insulin and leptin as well as slightly increased glucose and TNF-α values in the obese and obese-GDM groups.
|
21852675 |
2011 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Serum leptin levels were unchanged by hyperinsulinemia for 3 h during the clamp prior to the fast, while hyperinsulinemia for 3 h after 6 days of fasting increased serum leptin by 25% (P < 0.01).
|
9330585 |
1997 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Consistent with this idea, CNTF treatment of ob/ob mice, which lack functional leptin, was found to reduce the adiposity, hyperphagia, and hyperinsulinemia associated with leptin deficiency.
|
9177239 |
1997 |
|
Hyperinsulinism
|
0.700 |
Biomarker
|
disease |
BEFREE |
Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.
|
11956242 |
2002 |