|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Leptin expression increases after food intake and decreases during fasting and diabetes.
|
9342538 |
1997 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Obesity is associated with diabetes, and leptin is known to be elevated in obesity.
|
9389736 |
1997 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
We suggest that dysregulation of the adipoinsular axis in obese individuals due to defective leptin reception by beta-cells may result in chronic hyperinsulinemia and may contribute to the pathogenesis of adipogenic diabetes.
|
10022436 |
1999 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.
|
10485707 |
1999 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
This lipopenic effect of leptin may protect from the development of insulin resistance and diabetes in animals.
|
11145919 |
2001 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
However, a comparison among previous studies raises questions concerning possible genetic heterogeneity in other ethnic groups in which complex interactions among leptin, adiposity, and diabetes status may be important.
|
12006634 |
2002 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The extent to which leptin per se mediates the fetal growth and developmental abnormalities associated with disease states such as diabetes, hypoxia, or preeclampsia remains to be fully clarified by future studies in humans.
|
12087497 |
2002 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Topics covered are the roles of leptin and ghrelin in the regulation of food intake and energy production; the integration of food intake with other energy-regulated processes, such as growth, sexual maturation and reproduction, sleep and the immune response; and pathological conditions, ranging from diabetes to psychiatric disorders.1 This report summarizes conclusions of the meeting 'Brain Somatic Cross-Talk and the Central Metabolism' held in Paris on January 28, 2002.
|
12218345 |
2002 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Currently, PTP1B is being investigated by a number of companies as a promising target for leptin/insulin mimetics and in the treatment of diabetes and obesity.
|
12472377 |
2002 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
As a step towards functional studies, we have characterized leptin receptors in human placenta from normal pregnancies and pregnancies associated with diabetes and pre-eclampsia.
|
12495664 |
2003 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Compared with women without diabetes, those with diabetes had higher BMI (median values 23 vs. 24 kg/m(2), respectively; P = 0.03), increased chin skinfold thickness (10 vs. 20 mm; P = 0.001), lower rates of nulliparity (60% vs. 28%; P = 0.04), and higher levels of fasting serum triglycerides (2.4 vs. 3.5 mmol/l; P < 0.001) but similar serum leptin levels (3.4 vs. 3.6 ng/ml; P = 0.9).
|
12716787 |
2003 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Fasting glucose, plasma lipids, leptin, HbA(1c), and anthropomorphic measurements were evaluated in 13 subjects with clinical features of FPLD1 and are compared with two age-matched control groups, with and without diabetes.
|
12766116 |
2003 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
To gain further insight into the role of leptin in atherogenesis associated with diabetes, we investigated in the present study the role of this hormone in the regulation of macrophage lipoprotein lipase (LPL), a proatherogenic cytokine overexpressed in patients with type 2 diabetes.
|
12882931 |
2003 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
To verify whether a diabetes family history might be a risk factor for the development, in adult age, of metabolic disorders, leptin, anthropometric and endocrine parameters were analysed in 95 babies with grandparents affected by type 2 diabetes (DF) and in 95 matched babies without diabetes family history (NDF).
|
17536157 |
2007 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Several polymorphisms of leptin gene and its receptor have been described as potential developmental factors of pregnancy complications such as diabetes mellitus or pregnancy induced hypertension.
|
18050615 |
2007 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A 36-year-old female with PL associated with a heterozygous PPARG mutation complicated by poorly controlled diabetes and severe, refractory hypertriglyceridaemia was enrolled in a National Institutes of Health (NIH) protocol to evaluate the role of r-metHuLeptin in lipodystrophy.
|
18076675 |
2008 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, JNK inhibition may protect beta-cells from the deleterious effects of high glucose and leptin in diabetes.
|
18263705 |
2008 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Combined association of maternal and paternal family history of diabetes with plasma leptin and adiponectin in overweight Hispanic children.
|
19183309 |
2008 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
These data indicate that in diabetes increased FN production and cardiomyocyte hypertrophy may be mediated through leptin with its interaction with ET-1.
|
19391127 |
2009 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Effects of diabetes family history and exercise training on the expression of adiponectin and leptin and their receptors.
|
20153489 |
2011 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
These data provide novel evidence revealing the role of polymorphisms in LEPR in modulating plasma levels of sOB-R and may further our understanding of the complex relationships among leptin, leptin receptor and diabetes-related traits.
|
20167575 |
2010 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Some of them, including adiponectin and leptin, can influence the risk of development of diabetes and other associated metabolic and cardiovascular conditions.
|
20179670 |
2010 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies have demonstrated the long-term therapeutic effects of central leptin gene therapy in obesity and diabetes via decreased insulin resistance and increased glucose metabolism.
|
20690892 |
2010 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, we found MyD88-deficient mice fed a HFD had increased circulating levels of insulin, leptin and cholesterol, as well as liver dysfunction (increased induction of ALT levels, increased activation of JNK and cleavage of PARP), which were linked to the onset of severe diabetes.
|
20824098 |
2010 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It was negatively correlated with corpulence, but the correlation depended highly on caloric intake; 2) Escherichia coli species increased at M3 and inversely correlated with fat mass and leptin levels independently of changes in food intake; 3) lactic acid bacteria including Lactobacillus/Leuconostoc/Pediococcus group and Bifidobacterium genus decreased at M3; and 4) Faecalibacterium prausnitzii species was lower in subjects with diabetes and associated negatively with inflammatory markers at M0 and throughout the follow-up after surgery independently of changes in food intake.
|
20876719 |
2010 |