|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Adiponectin and leptin are implicated in the initiation and pathomechanism of Alzheimer's disease (AD).
|
28442988 |
2017 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
We also discuss relevant issues such as the role of leptin, insulin and renin-angiotensin signaling in the brain and the possible role of Wnt signaling in both MS and AD.
|
25084549 |
2014 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin, once established as a biomarker, could enhance the understanding of late-onset AD risk over the life course, as well as the clinical progression of prodromal state to manifested AD.
|
26279362 |
2015 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The most prevalent non-amnestic cognitive manifestations in participants in the DIAN-OBS cohort were those typical of mild to moderate Alzheimer's disease, including visual agnosia (55·1%, 95% CI 45·7-64·6), aphasia (57·9%, 48·6-67·3), and behavioural changes (61·7%, 51·5-70·0).
|
27777020 |
2016 |
|
Alzheimer's Disease
|
0.600 |
Therapeutic
|
disease |
RGD |
Amyloid beta lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity.
|
25296496 |
2014 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ε4 allele.
|
29070909 |
2017 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In MCI/AD, both the CSF and serum samples had significantly elevated mean levels of C-peptide and an incretin, and reduced expression of Visfatin, whereas only CSF showed significant reductions in insulin and leptin and only serum had increased glucagon, PAI-1, and ghrelin.
|
30775986 |
2019 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The present study confirms the associations between leptin and adiponectin and AD or AD-related disorders but did not confirm that these peptides may be used as predictive biomarkers of cognitive decline.
|
30400097 |
2018 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Combination therapy with leptin and pioglitazone ameliorates pathologic changes in APP/PS1 mice and may represent a potential treatment approach for AD.
|
29067321 |
2017 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that leptin levels are intact, but leptin signalling is impaired in AD.
|
25453257 |
2015 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Amnestic mild cognitive impairment (MCI, n = 71) and Alzheimer's dementia (AD, n = 53) subjects were consecutively recruited for serum and CSF adiponectin and leptin determination using an analytically validated commercial enzyme-linked immunosorbent assay (ELISA).
|
30689587 |
2019 |