|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Methylation in neuropeptide Y (NPY), leptin (LEP), and leptin receptor (LEPR) was significantly higher in TU compared with N-Adj tissues (P<.0001) in both the discovery and validation groups.
|
28543182 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
All cell lines showed a significant decrease in cell adhesion and increase in cell migration after incubation with hRATnT-CMs <i>vs.</i> hRATfT- or control-CMs. hRATnT-CMs showed increased levels of versican and leptin, compared to hRATfT-CMs.
|
29212223 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the multivariable model with adjustment for established breast cancer risk factors, serum leptin was a significant predictor of breast cancer risk (OR 1.746; 95% CI, 1.226-2.556) and clinicopathological characteristics of breast cancer including TNM, tumor size, lymph node status, and histological grade (OR 1.461-1.695); but when marrow FF was additionally added to the regression model, marrow FF but not leptin levels was observed to be an independent risk factor for breast cancer risk (OR 1.940; 95% CI, 1.306-2.910) and clinicopathological characteristics of breast cancer (OR 1.770-1.903).
|
28188108 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Plasma adiponectin and leptin levels were not significantly associated with tumor characteristics at the time of diagnosis.
|
28454352 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Vascular Endothelial Growth Factor A and Leptin Expression Associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.
|
28192065 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Normal and tumor cells respond to metabolic hormones, such as leptin and insulin.
|
27842582 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
They also displayed significantly higher levels of leptin; however, there was a negative correlation between leptin levels and tumor size.
|
27866828 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After stimulated by leptin, we established a co-culture system of tumor cells and macrophages to evaluate the function of leptin-induced macrophages in the migration and invasion of breast cancer cells.
|
27082857 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our results demonstrate that leptin-induced tumor growth is mediated by autophagy induction and autophagic process would be a promising target to regulate development of cancer caused by leptin production.
|
25704884 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The overexpression of leptin was shown to significantly promote tumor growth and lymph node metastasis in a subcutaneous model and an orthotopic model of human pancreatic cancer, respectively.
|
25948792 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Similarly, in the independent cohort (n=154), higher leptin protein expression by immunohistochemistry in the tumour cells was associated with lack of histopathological response (P=0.007).
|
24569475 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
EB1089 did not alter HFD-induced increase in serum leptin levels but increased miR-498 and decreased the diet-induced hTERT expression in tumors.
|
25252917 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review provides a general overview of the biology of leptin, important laboratory studies, and animal and clinical models that have provided evidence for an active role of leptin in the proliferation, progression, and survival of mammary tumors.
|
23869900 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nude mice with xenografts of MCF-7 human breast cancer cells were administered recombinant human leptin subcutaneous via injection around the tumor site.
|
22800822 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Leptin did not correlate significantly with clinical stage, tumour grade, or with the expression of hTERT or COX2.
|
23162077 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A nude mouse xenograft model can be safely and efficiently treated with human leptin by subcutaneous injections around the tumor.
|
22490496 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Individual features of MetS correlated with Ob and ObR expression, but not obesity markers (BMI, waist circumference). mRNA expression of leptin (Ob) and ObR, in adipose tissue and matched tumor samples, respectively, appear to be associated with obesity status in breast cancer.
|
21574190 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of either protein was associated with greater neoplasm size (leptin expression, 32.0 +/- 10.7 vs 20.5 +/- 8.4 mm; P = .001; leptin receptor expression, 27.9 +/- 11.5 vs 21.4 +/- 9.0 mm; P = .032).
|
20045163 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This is the first report about leptin expression in this tumor entity.
|
20647974 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, we reported the oncogenic role of leptin including its potential to increase tumor invasiveness and migration of hepatocellular carcinoma (HCC) cells.
|
20941777 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nude mouse xenograft model can be safely and serviceably treated with human leptin by subcutaneous injections around tumor.
|
20193256 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it.
|
21263187 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor VEGF levels were the highest in the obese mouse tumors (p < 0.05), regardless of the host leptin levels.
|
19713740 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to compare the effects of leptin-stimulated colon epithelial cells differing in adenomatous polyposis coli (Apc) genotype (gatekeeper tumor suppressor gene for colon cancer) on angiogenesis.
|
19221001 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Several studies have implicated leptin in the pathophysiology of neoplasias.
|
19665393 |
2009 |