|
Alzheimer's Disease
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Increasing evidence has revealed that vascular risk factors influence the midlife development of AD and that diet-induced obesity accelerates tau phosphorylation in tau transgenic mice and increases the level of serum leptin receptor (leptin-R).
|
30954605 |
2019 |
|
Aplastic Anemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Altered expression of leptin and leptin receptor in the development of immune-mediated aplastic anemia in mice.
|
31316601 |
2019 |
|
Anorexia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
One subpopulation co-expresses the long form of the leptin receptor (LepRb) and is activated by the anorectic hormone leptin (Nts<sup>LepRb</sup> neurons).
|
30755658 |
2019 |
|
Autistic Disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we evaluate the ability of miR-153 to influence brain-derived neurotrophic factor (BDNF) of autism as well as proliferation and apoptosis of hippocampal neuron through the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway by targeting leptin receptor (LEPR).
|
30975733 |
2019 |
|
Dehydration
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
A separate subpopulation lacks LepRb and is activated by dehydration (Nts<sup>Dehy</sup> neurons).
|
30755658 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mice were subjected to diabetes mellitus either by streptozotocin injections (type 1 diabetes mellitus model) or by crossing into mice carrying a leptin receptor mutation (db/db; type 2 diabetes mellitus model) and monitored for remodeling and cardiac function.
|
31195810 |
2019 |
|
Hypoglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GHR ablation in LepR cells led to impaired capacity to recover from insulin-induced hypoglycemia and to a blunted CRR caused by 2-deoxy-d-glucose (2DG) administration.
|
31366244 |
2019 |
|
Rhinovirus infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.
|
31462495 |
2019 |
|
Progressive Neoplastic Disease
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, patients in the progressive disease group had high and low expression of leptin and LEPR: 13.25% versus 11.32% and 13.1% versus 10.42% respectively.
|
31015393 |
2019 |
|
Post transplant diabetes mellitus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Variability in the leptin receptor gene and other risk factors for post-transplant diabetes mellitus in renal transplant recipients.
|
31046466 |
2019 |
|
Cerebral hypoperfusion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice.
|
30954605 |
2019 |
|
Neonatal Opiate Withdrawal Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In NOWS requiring pharmacotherapy expression of leptin receptor, an appetite suppressor, was higher in male subjects than female subjects (Δ threshold cycle 8.4 ± 2.5 vs 12.4 ± 5.1, P = .05), DRD2 expression significantly correlated with intake volume on day of life 7 (r = 0.58, P = .02), and expression of NPY2R, an appetite regulator, negatively correlated with length of stay (r = -0.24, P = .05).
|
31474426 |
2019 |
|
Progressive cGVHD
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, patients in the progressive disease group had high and low expression of leptin and LEPR: 13.25% versus 11.32% and 13.1% versus 10.42% respectively.
|
31015393 |
2019 |
|
Severe periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The risk of T2DM was higher in moderate/severe periodontitis [adjusted odds ratio (AOR) = 3.67, 95% confidence interval (95%CI): 1.26-10.71] in ADIPOQ-rs1501299 GG genotype (AOR = 3.42, 95%CI: 1.81-6.46) and LEPR-rs1137100 GG genotype (AOR = 3.16, 95%CI: 1.56-6.39).
|
31128439 |
2019 |
|
Obstructive sleep apnea hypopnea syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Of the seven case-control studies we enrolled, there was insignificant correlation of the LEPR Gln223Arg polymorphism with OSAHS risk.
|
31679272 |
2019 |
|
Postoperative cognitive dysfunction
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of the present study was to compare the effects of α-lipoic acid (ALA) on postoperative cognitive dysfunction (POCD) between wild type (WT) and leptin receptor-deficient (db/db) mice and to elucidate the underlying mechanism of treatment with ALA.
|
30867718 |
2019 |
|
Cachexia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Preparation of Potent Leptin Receptor Antagonists and Their Therapeutic Use in Mouse Models of Uremic Cachexia and Kidney Fibrosis.
|
29366406 |
2018 |
|
Polyarteritis Nodosa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We relatively display leptin and leptin receptor expression levels in pan-cancer panel based on the transcriptome analysis via dataset The Cancer Genome Atlas (TCGA), and show the clinical association of the axis in predicting cancer prognosis.
|
29682217 |
2018 |
|
Lobar Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since leptin deficiency is associated with obesity and other metabolic abnormalities, we generated mice that lack the leptin receptor (LepRb) in cells of the myeloid linage (LysM-LepRb-KO) to evaluate its impact in lean metabolically normal mice in a murine model of pneumococcal pneumonia.
|
29565180 |
2018 |
|
Varicocele
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of leptin and the leptin receptor in the pathogenesis of varicocele-induced testicular dysfunction.
|
29568885 |
2018 |
|
T-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggested that leptin serves a critical role in TCL glucose uptake via the ObR.
|
30333864 |
2018 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Preparation of Potent Leptin Receptor Antagonists and Their Therapeutic Use in Mouse Models of Uremic Cachexia and Kidney Fibrosis.
|
29366406 |
2018 |
|
Testicular hypogonadism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity.
|
29948931 |
2018 |
|
Streptococcal pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since leptin deficiency is associated with obesity and other metabolic abnormalities, we generated mice that lack the leptin receptor (LepRb) in cells of the myeloid linage (LysM-LepRb-KO) to evaluate its impact in lean metabolically normal mice in a murine model of pneumococcal pneumonia.
|
29565180 |
2018 |
|
Pseudolymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A higher level of ObR expression was observed in the TCL tissues than in the RLH tissues (58.3 vs. 22.2%; P=0.012), and ObR overexpression was associated with high expression of Glut1 (P=0.007).
|
30333864 |
2018 |