|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
131 cervical biopsies, including 8 cases with no lesion and a negative hrHPV test result (control group), 19 low-grade (L)SIL/CIN1, 30 HSIL/CIN2, 60 HSIL/CIN3, and 14 CC were prospectively collected. hrHPV was detected and genotyped using the polymerase chain reaction (PCR)-based technique SPF10 HPV LIPA.
|
31067838 |
2019 |
|
Apathy
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Using a 2 × 2 MANOVA with depression (CESD ≥ 16) and apathy (AES ≥ 34) as the independent variables and cognitive performance (i.e., verbal acquisition, short-term free recall, and long-term free recall) as the dependent variables, we found a main effect for apathy (F[3,134] = 2.98, p = .034), such that apathetic stroke patients (n = 24) performed significantly worse on verbal acquisition (F[1,136] = 6.44; p = .012), short-term free recall (F[1,136] = 7.86; p = .006), and long-term free recall (F[1,136] = 8.37; p = .004) than nonapathetic stroke patients (n = 116).
|
29788381 |
2019 |
|
Malignant neoplasm of anus
|
0.010 |
Biomarker
|
disease |
BEFREE |
A retrospective study carried out over a 10-year period, using clinical and molecular data, with PCR analysis and reverse hybridization (INNO-LIPA kit), in anal cancers.
|
31641354 |
2019 |
|
Anal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A retrospective study carried out over a 10-year period, using clinical and molecular data, with PCR analysis and reverse hybridization (INNO-LIPA kit), in anal cancers.
|
31641354 |
2019 |
|
Cervical Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A total of 718 paraffin-embedded ADC specimens were collected in China and tested for HPV genotypes using SPF10-INNO-LIPA.
|
31347710 |
2019 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
131 cervical biopsies, including 8 cases with no lesion and a negative hrHPV test result (control group), 19 low-grade (L)SIL/CIN1, 30 HSIL/CIN2, 60 HSIL/CIN3, and 14 CC were prospectively collected. hrHPV was detected and genotyped using the polymerase chain reaction (PCR)-based technique SPF10 HPV LIPA.
|
31067838 |
2019 |
|
Nonalcoholic Steatohepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with NAFLD show a significant, progressive reduction of LAL activity from simple steatosis to non-alcoholic steatohepatitis and cryptogenic cirrhosis.
|
31435171 |
2019 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
131 cervical biopsies, including 8 cases with no lesion and a negative hrHPV test result (control group), 19 low-grade (L)SIL/CIN1, 30 HSIL/CIN2, 60 HSIL/CIN3, and 14 CC were prospectively collected. hrHPV was detected and genotyped using the polymerase chain reaction (PCR)-based technique SPF10 HPV LIPA.
|
31067838 |
2019 |
|
Fatty Liver Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The value of LAL activity progressively decreased from healthy subjects to NAFL/NASH patients to CC (P < .001).
|
31392821 |
2019 |
|
Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Participants with complete data on religiosity (i.e., religious affiliation, frequency of attending religious activities and importance of religion), depression (assessed with the CESD-10), and trait anxiety (assessed with the STAI-10) were included in the present study.
|
29415030 |
2018 |
|
Anxiety Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Participants with complete data on religiosity (i.e., religious affiliation, frequency of attending religious activities and importance of religion), depression (assessed with the CESD-10), and trait anxiety (assessed with the STAI-10) were included in the present study.
|
29415030 |
2018 |
|
Balkan Nephropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Because modest nuclear enlargement of kidney tubule cells can occur as physiological or functional responses, it is recommended that the threshold for diagnosing renal tubule karyomegaly in animal studies should be accepted as at least four times normal nuclear size or larger.Abbreviations: BEN: Balkan Endemic Nephropathy; DMN: dimethylnitrosamine; GLP: Good Laboratory Practice; KIN: karyomegalic interstitial nephritis; LAL: lysinoalanine; MeCCNU: 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea; NTP: National Toxicology Program; OSOM: outer stripe of outer medulla; OTA: ochratoxin A; RTT: renal tubule tumor.
|
30277423 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LAL was up-regulated in ccRCC tissue.Tissue microarray analysis revealed higher levels of LAL in advanced grades of ccRCC, and high LAL expression indicated lower patient survival.
|
29569766 |
2018 |
|
INTERSTITIAL NEPHRITIS, KARYOMEGALIC
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because modest nuclear enlargement of kidney tubule cells can occur as physiological or functional responses, it is recommended that the threshold for diagnosing renal tubule karyomegaly in animal studies should be accepted as at least four times normal nuclear size or larger.Abbreviations: BEN: Balkan Endemic Nephropathy; DMN: dimethylnitrosamine; GLP: Good Laboratory Practice; KIN: karyomegalic interstitial nephritis; LAL: lysinoalanine; MeCCNU: 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea; NTP: National Toxicology Program; OSOM: outer stripe of outer medulla; OTA: ochratoxin A; RTT: renal tubule tumor.
|
30277423 |
2018 |
|
Aristolochic Acid Nephropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Because modest nuclear enlargement of kidney tubule cells can occur as physiological or functional responses, it is recommended that the threshold for diagnosing renal tubule karyomegaly in animal studies should be accepted as at least four times normal nuclear size or larger.Abbreviations: BEN: Balkan Endemic Nephropathy; DMN: dimethylnitrosamine; GLP: Good Laboratory Practice; KIN: karyomegalic interstitial nephritis; LAL: lysinoalanine; MeCCNU: 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea; NTP: National Toxicology Program; OSOM: outer stripe of outer medulla; OTA: ochratoxin A; RTT: renal tubule tumor.
|
30277423 |
2018 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of note, lysosomal acid lipase (LAL) deficiency facilitates melanoma growth and metastasis.
|
28924047 |
2017 |
|
Pancytopenia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LAL activity is also correlated with platelet and white blood cell count, suggesting an analytic interference of portal-hypertension-induced pancytopenia on DBS-determined LAL activity.
|
28587063 |
2017 |
|
Peyronie Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two senior surgeons (GH, LAL) describe their surgical technique in detail, and provide important aspects and tips one has to be aware of when performing a grafting technique in patients with PD.
|
28904897 |
2017 |
|
Lipid Metabolism Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
LAL-D should be considered in the differential diagnosis of healthy weight children and young adults with unexplained hepatic transaminase elevation accompanied by an elevated LDL-C level (>160 mg/dL) and low HDL-C level (<35 mg/dL) that is not caused by monogenic and polygenic lipid disorders or secondary factors.
|
28197978 |
2017 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that LDAH is not a major cholesterol ester hydrolase, and an alternative metabolic function may be responsible for its possible effect on development of prostate cancer.
|
27836991 |
2017 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that LDAH is not a major cholesterol ester hydrolase, and an alternative metabolic function may be responsible for its possible effect on development of prostate cancer.
|
27836991 |
2017 |
|
Acute Chest Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic study of 7 genes (LDLR, APOB, PCSK9, APOE, STAP1, LDLRAP1, and LIPA) associated with FH and 12 common alleles associated with polygenic hypercholesterolemia was performed in 103 patients with ACS, age ≤65 years, and LDL-C levels ≥160 mg/dl.
|
28958330 |
2017 |
|
Arteriosclerotic cardiovascular disease, NOS
|
0.010 |
Biomarker
|
disease |
BEFREE |
LAL-D is characterized by accelerated atherosclerotic cardiovascular disease (ASCVD) and hepatic microvesicular or mixed steatosis, leading to inflammation, fibrosis, cirrhosis and liver failure.
|
28197978 |
2017 |
|
Infant Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An infant, was referred to us with suspected infant leukemia and was subsequently diagnosed to have lysosomal acid lipase deficiency/Wolman disease with a novel 5 bp deletion "c.1180_1184del" in the last exon (exon 10) of the lipase A (LIPA) gene.
|
28538091 |
2017 |
|
Blood spots
|
0.010 |
Biomarker
|
disease |
BEFREE |
Best practice in the measurement and interpretation of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2.
|
28532785 |
2017 |