|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BCAR4 expression was examined by qPCR in 30 cases of graded glioma specimens and 7 glioblastoma (GBM) cell lines compared with respective controls.
|
31849498 |
2019 |
|
Hyperthyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that targeting BCAR4 has potential in hyperthyroidism treatment.
|
30569716 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Tumor xenograft was conducted to determine the effects of BCAR4 and <i>GLI2</i> on NSCLC tumorigenesis in vivo.
|
29615150 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BCAR4 expression was examined by qPCR in 30 cases of graded glioma specimens and 7 glioblastoma (GBM) cell lines compared with respective controls.
|
31849498 |
2019 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we concentrated on the biological function and clinical significance of BCAR4 in cervical cancer.
|
29937186 |
2018 |
|
Multiple tumors
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Long non-coding RNA (lncRNA) breast cancer anti-estrogen resistance 4 (BCAR4) has been proved to promote proliferation and metastasis in multiple tumors.
|
29937186 |
2018 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we concentrated on the biological function and clinical significance of BCAR4 in cervical cancer.
|
29937186 |
2018 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, our data suggest that BCAR4 may activate GLI2 signaling in PC to contribute to castration resistance.
|
30513511 |
2018 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, our data suggest that BCAR4 may activate GLI2 signaling in PC to contribute to castration resistance.
|
30513511 |
2018 |
|
Hormone refractory prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, BCAR4 activated GLI2 downstream genes, and correlated with the levels of these GLI2-target genes in CRPC.
|
30513511 |
2018 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we concentrated on the biological function and clinical significance of BCAR4 in cervical cancer.
|
29937186 |
2018 |
|
Hormone sensitive prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we showed that a lncRNA, Breast-Cancer Anti-Estrogen Resistance 4 (BCAR4), which plays a pivotal role in the tamoxifen-resistance of breast cancer, was significantly upregulated in CRPC, but not in castration-sensitive prostate cancer (CSPC), compared to normal prostate tissue.
|
30513511 |
2018 |
|
Chondrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, BCAR4 overexpression had significant promoting effect on cell proliferation and migration in chondrosarcoma cells.
|
28399646 |
2017 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
We showed that BCAR4 was closely related with the cisplatin-resistant gastric cancer.
|
29028095 |
2017 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We showed that BCAR4 was closely related with the cisplatin-resistant gastric cancer.
|
29028095 |
2017 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistently, knockdown of BCAR4 inhibits osteosarcoma tumorigenesis and lung metastasis in vivo.
|
27460090 |
2016 |
|
Breast cancer, lobular
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Relative high BCAR4 mRNA expression was identified in IPH-926, a cell line derived from an endocrine-resistant lobular breast cancer.
|
26317614 |
2015 |
|
Oestrogen receptor positive breast cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study shows that BCAR4 expression identifies a subgroup of ER-positive breast cancer patients without overexpression of ERBB2 who have a poor outcome and might benefit from combined ERBB2-targeted and antioestrogen therapy.
|
22892392 |
2012 |
|
Thymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In BCAR4-expressing cells, phosphorylation of v-erb-b2 erythroblastic leukaemia viral oncogene homolog (ERBB)2, ERBB3, and their downstream mediators extracellular signal-regulated kinase 1/2 and v-akt murine thymoma viral oncogene homolog (AKT) 1/2, was increased.
|
20859285 |
2010 |
|
Malignant tumor of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we hypothesized that BCAR4 could regulate colon cancer stem/initiating cells (CSC) function and further facilitates the colon cancer progression.
|
30962766 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Breast cancer anti-estrogen resistance 4 promotes the CRC cells stemness through targeting to miR-665/STAT3 signaling and identification of the BCAR4 in CRC stem cells provides a new insight into CRC diagnosis, treatment, prognosis and next-step translational investigations.
|
30962766 |
2019 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This research intends to investigate the impact and internal molecular mechanism of BCAR4 on glioma cell growth, invasion and tumorigenesis.
|
31849498 |
2019 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings disclosed that BCAR4 contributes to glioma progression by enhancing cell growth via activating EGFR/PI3K/AKT pathway, providing potent evidence that BCAR4 could be an effective new target for treatment and prognosis of glioma patients.
|
31173355 |
2019 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we hypothesized that BCAR4 could regulate colon cancer stem/initiating cells (CSC) function and further facilitates the colon cancer progression.
|
30962766 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
LncRNA BCAR4, targeting to miR-665/STAT3 signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal cancer.
|
30962766 |
2019 |