|
Hypertriglyceridemia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
To test whether abnormalities in multiphasic release of lipoprotein lipase are associated with hypertriglyceridemia in diabetes mellitus, postheparin lipolytic activity (PHLA) was measured during a high-dose, constant heparin infusion in 20 diabetic subjects with hypertriglyceridemia, 25 nondiabetic hypertriglyceridemic subjects and 7 normal subjects.
|
1165728 |
1975 |
|
Hypertriglyceridemia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Within the nuclear family, the mother and two of the proband's five siblings had fasting hypertriglyceridemia or low-normal tissue adipose LPL activities or both.
|
6645961 |
1983 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Hypertriglyceridaemia due to genetic defects in lipoprotein lipase and apolipoprotein C-II.
|
1619390 |
1992 |
|
Hypertriglyceridemia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia.
|
8349676 |
1993 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Subjects with NIDDM and wild-type LPL, and nondiabetic middle-aged carriers of the 73Tyr-->Ter truncation had moderate hypertriglyceridemia (260-521 mg/dl) and reduced high density lipoprotein cholesterol.
|
8325986 |
1993 |
|
Hypertriglyceridemia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
These findings indicate that chylomicrons compete with VLDL for removal of triglycerides by lipoprotein lipase and that the postprandial metabolism of triglyceride-rich lipoproteins is severely defective in hypertriglyceridemia.
|
8450056 |
1993 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Our data suggest that coding region mutations of the LPL gene cannot account for the elevated triglyceride and low HDL levels noted in diabetic individuals and their relatives in most NIDDM pedigrees, but the exon 2 Asn variant may contribute to the hypertriglyceridemia in some families.
|
7962342 |
1994 |
|
Hypertriglyceridemia
|
0.600 |
Therapeutic
|
phenotype |
CTD_human |
These results suggest that the expression of LPL enzyme protein is impaired in patients with hypertriglyceridemia coupled with hypertension, impaired glucose tolerance and hyperinsulinemia, and the impaired expression of LPL recovers during treatment with bezafibrate, resulting in improvement of hypertriglyceridemia.
|
8147947 |
1994 |
|
Hypertriglyceridemia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
These results suggest that the expression of LPL enzyme protein is impaired in patients with hypertriglyceridemia coupled with hypertension, impaired glucose tolerance and hyperinsulinemia, and the impaired expression of LPL recovers during treatment with bezafibrate, resulting in improvement of hypertriglyceridemia.
|
8147947 |
1994 |
|
Hypertriglyceridemia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
We investigated measures for identification of heterozygous lipoprotein lipase (LPL) deficiency in unrelated subjects with primary type IV hyperlipoproteinemia in order to acquire a helpful clue for understanding the correlation between hypertriglyceridemia and the status of being a heterozygous carrier of an LPL gene variant.
|
7868979 |
1994 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
However, hypertriglyceridemia and an increased cholesterol-to-HDL cholesterol ratio were observed in the hyperinsulinemic state irrespective of LPL-HindIII genotype status.(ABSTRACT TRUNCATED AT 250 WORDS)
|
7749885 |
1995 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Thus, although the precise mechanism of the effect is unclear, the data strongly suggest that the LPL-Asn9 variant is associated with and may play a direct role in predisposing carriers to develop hypertriglyceridemia.
|
7749858 |
1995 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Heterozygosity for Asn291-->Ser mutation in the lipoprotein lipase gene in two Finnish pedigrees: effect of hyperinsulinemia on the expression of hypertriglyceridemia.
|
8732773 |
1996 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Linkage analysis revealed no significant relationship between the D9N or N291S LPL gene mutations and the FCH phenotype (hypertriglyceridaemia, hypercholesterolaemia or increased apo B concentrations).
|
8872057 |
1996 |
|
Hypertriglyceridemia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
We examined the lipoprotein lipase (LPL) gene by single strand conformation polymorphism (SSCP) and by restriction fragment length polymorphism (RFLP) analysis in 106 patients with hypertriglyceridemia to screen for novel mutations and to study the contribution of LPL genetic defects in hypertriglyceridemia.
|
9225235 |
1996 |
|
Hypertriglyceridemia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Familial lipoprotein lipase (LPL) deficiency is an inherited disorder of lipoprotein metabolism characterized by hypertriglyceridemia and recurrent episodes of abdominal pain and pancreatitis.
|
8728326 |
1996 |
|
Hypertriglyceridemia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Correction of hypertriglyceridemia and impaired fat tolerance in lipoprotein lipase-deficient mice by adenovirus-mediated expression of human lipoprotein lipase.
|
9409224 |
1997 |
|
Hypertriglyceridemia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
This suggests that the extensive hypertriglyceridemia in our patient was due to an L-asparaginase-induced decrease in LPL activity.
|
9264396 |
1997 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
These results provide evidence of interaction between obesity and the HindIII polymorphism of the lipoprotein lipase gene on the risk of HTG.
|
9272150 |
1997 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Patients with mutations on both alleles of the lipoprotein lipase gene resulting in complete lipoprotein lipase deficiency exhibit the chylomicronemia syndrome with severe hypertriglyceridemia and increased risk of pancreatitis and possibly of ischemic heart disease.
|
9323055 |
1997 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Gene therapy to deliver and express a corrective lipoprotein lipase (LPL) gene may improve the lipid profile and reduce the morbidity and potential atherogenic risk from hypertriglyceridemia and dyslipoproteinemia in patients with complete or partial LPL deficiency.
|
9017424 |
1997 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
However, significant heterogeneity in their plasma triglyceride levels has been found, even among individuals carrying the same LPL gene mutation, indicating that factors other than LPL deficiency could affect the phenotypic expression of hypertriglyceridemia in the heterozygous state.
|
9392497 |
1997 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
The Asn-291-->Ser and Ser-477-->Stop mutations of the lipoprotein lipase gene and their significance for lipid metabolism in patients with hypertriglyceridaemia.
|
9395789 |
1997 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
The two CAD patients heterozygous for the LPL(Gly188-->Glu) mutation, however, had hypertriglyceridemia and low plasma high density lipoprotein levels.
|
9627528 |
1998 |
|
Hypertriglyceridemia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
Here we report a novel LPL gene mutation (Glu421Lys), in a previously healthy primigravid woman who died from hypertriglyceridemia-induced pancreatitis during the last trimester of pregnancy.
|
9498099 |
1998 |