Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association studies were carried out on a sample of 87 patients from Sweden who had survived a myocardial infarction (MI) at a young age and 93 age-matched healthy individuals, to compare the impact of polymorphisms (PvuII, HindIII and Serine447-Stop) at the lipoprotein lipase (LPL) gene locus on among-individual differences in plasma lipid traits and progression of atherosclerosis.
|
1466662 |
1992 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that macrophage-derived foam cells are the primary source of LPL in atherosclerotic plaques and are consistent with a role for LPL in the pathogenesis of atherosclerosis.
|
1569193 |
1992 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data support the relationship between LPL activity and HDL-C levels, and suggest that a specific LPL mutation may be a factor in the development of atherosclerosis.
|
7647785 |
1995 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Association studies were carried out in a sample of 86 patients from Sweden who had survived a myocardial infarction (MI) at a young age and 93 age-matched healthy individuals, to compare the impact of polymorphisms at the apolipoprotein (apo) AI-CIII-AIV gene cluster on among-individual differences in plasma lipid and lipoprotein traits, the five high density lipoprotein (HDL) subclasses (2b to 3c), lipoprotein lipase (LPL) activity and presence and progression of atherosclerosis.
|
7834891 |
1994 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accordingly, LPL qualifies as a candidate gene for understanding lipid metabolic disorders and atherosclerosis.
|
8026810 |
1994 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Enhanced understanding of LPL structure, function and mechanism of action has provided insights into new potential pathways by which defects in LPL function may result in the development of different hyperlipidemic disorders and/or atherosclerosis.
|
8044414 |
1994 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
An LPL-specific monoclonal antibody demonstrated that, similar to apo E, LPL protein on foam cell and non-foam cell macrophages was detected in atherosclerotic lesions, but LPL was also localized to intimal muscle smooth muscle cells and was not distributed as widely in association with matrix as was apo E. The expression of both apo E and LPL in atherosclerotic lesions but not in normal intima suggest that these molecules play a role in lipid metabolism in atherosclerosis.
|
8129039 |
1994 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated associations of LPL polymorphisms (HindIII, PvuII, Ser447-->Ter) and the newly described mutation Asn291-->Ser with the risk of myocardial infarction (MI), severity of atherosclerosis, and fasting plasma lipoprotein concentrations in the ECTIM study (614 patients and 733 controls).
|
8576640 |
1995 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the effects of the overexpressed LPL on diet-induced atherosclerosis, we have generated low density lipoprotein receptor (LDLR) knockout mice that overexpressed human LPL transgene (LPL/LDLRKO) and compared their plasma lipoproteins and atherosclerosis with those in nonexpressing LDLR-knockout mice (LDLRKO).
|
8692976 |
1996 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many diseases, including obesity, coronary heart disease, chylomicronemia (pancreatitis), and atherosclerosis, appear to be directly or indirectly related to abnormalities in LPL function.
|
8843465 |
1996 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the LPL HindIII polymorphism influences LPL-catalyzed, triglyceride-rich lipoprotein metabolism and carotid artery atherosclerosis in a gender-specific manner.
|
8882874 |
1996 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The LPL Ser447-Stop mutation therefore should have a protective effect against the development of atherosclerosis and subsequent CAD.
|
9193431 |
1997 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies.
|
9264476 |
1997 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Greater knowledge of the underlying mechanisms of these variations within the LPL gene may be of considerable importance in understanding genetic predisposition to atherosclerosis and heart disease.
|
9430364 |
1997 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, overproduction of LPL is protective against atherosclerosis even in the absence of apoE.
|
10484615 |
1999 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulating evidence indicates that lipoprotein lipase (LPL) produced by macrophages in the vascular wall may favor the development of atherosclerosis by promoting lipid accumulation within the lesion.
|
10871197 |
2000 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that expression of human apoA-II in apoE-deficient mice induces a dose-dependent increase in VLDL, resulting in plasma triglyceride elevations of up to 24-fold in a mouse line that has 2-fold the concentration of human apoA-II of normolipidemic humans, as well as other well-known characteristics of FCHL: increased concentrations of cholesterol, triglyceride, and apoB in very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and low density lipoprotein (LDL), reduced HDL cholesterol, normal lipoprotein lipase and hepatic lipase activities, increased production of VLDL triglycerides, and increased susceptibility to atherosclerosis.
|
10946021 |
2000 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrate that systemically increased LPL activity functions in the metabolism of all classes of lipoproteins, thereby playing a crucial role in plasma triglyceride hydrolysis and lipoprotein conversion, and that overexpression of LPL protects against diet-induced hypercholesterolemia and atherosclerosis.
|
11477088 |
2001 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results establish that macrophage LPL accelerates atherosclerosis in male apolipoprotein E knockout mice.
|
11701470 |
2001 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No evidence of accelerated atherosclerosis in a 66-yr-old chylomicronemia patient homozygous for the nonsense mutation (Tyr61-->stop) in the lipoprotein lipase gene.
|
11730817 |
2001 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For this reason, we sought to examine the association between polymorphisms in the lipoprotein lipase (LPL) and apolipoprotein E (APOE) genes and subclinical and clinical stroke in the Atherosclerosis Risk in Communities (ARIC) Study.
|
11921083 |
2002 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the effects of diabetes on lipoprotein profiles and atherosclerosis in a rodent model, we crossed mice that express human apolipoprotein B (HuB), mice that have a heterozygous deletion of lipoprotein lipase (LPL1), and transgenic mice expressing human cholesteryl ester transfer protein (CETP).
|
12032161 |
2002 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Unlike LPL and HL, EL is located in the vascular endothelial cells and its expression is highly regulated by cytokines and physical forces, suggesting that it may play a role in the development of atherosclerosis.
|
12401876 |
2002 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, abnormalities in LPL function have been found to be associated with a number of pathophysiological conditions, including atherosclerosis, chylomicronaemia, obesity, Alzheimer's disease, and dyslipidaemia associated with diabetes, insulin resistance, and infection.
|
12483461 |
2002 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, it has been recently reported that some heterozygous and homozygous LPL-deficient patients are associated with premature atherosclerosis.
|
12641539 |
2003 |