|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Fifteen common polymorphic variants at six loci (apolipoproteins AI, B, CIII and E, hepatic lipase and lipoprotein lipase) involved in plasma lipid transport have been studied in 210 northern Spanish men, of whom 98 had proven coronary artery disease.
|
11171287 |
2001 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
This augmented LPL-N9 bridging provides a mechanism for the reported increased CAD risk in N9 carriers.
|
12535736 |
2003 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
We then selected four candidate biomarkers and found that lipoprotein lipase (LPL), bone morphogenetic protein 7 and somatostatin concentrations could indicate CAD diagnosis.
|
30958112 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We used polymerase chain reaction and restriction enzyme digestion to determine the distribution of the LPL-HindIII and LPL-PvuII polymorphisms among healthy blood donors of Arabic origin (BD group) and angiographically confirmed CAD patients (CAD group) with identical ethnic backgrounds.
|
12708905 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several polymorphisms in the lipoprotein lipase locus have been described and are associated with variations in the activity of this enzyme, producing high concentrations of triglycerides and increased risk of CAD.
|
31227920 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein lipase D9N, N291S and S447X polymorphisms: their influence on premature coronary heart disease and plasma lipids.
|
11427211 |
2001 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The distributions of LPL genotype and allele did not differ between the CAD and control groups.
|
12919138 |
2003 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the gene encoding lipoprotein lipase in men with low HDL-C and coronary heart disease: the Veterans Affairs HDL Intervention Trial.
|
15292370 |
2004 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of lipoprotein lipase S447X and apolipoprotein E genotypes with low-density lipoprotein subfractions in Turkish patients with coronary artery disease.
|
19368142 |
2009 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A statistically significant increase in the risk of CAD was associated with LPL HindIII polymorphism.
|
28275220 |
2017 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop).
|
15657615 |
2005 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variations in the lipoprotein lipase (LPL) gene have been implicated in a number of pathophysiologic conditions associated with coronary heart disease.
|
16168296 |
2005 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ANGPTL4 inhibits lipoprotein lipase; we therefore searched for mutations in LPL and identified a loss-of-function variant that was associated with an increased risk of coronary artery disease (p.D36N; minor-allele frequency, 1.9%; odds ratio, 1.13; P=2.0×10(-4)) and a gain-of-function variant that was associated with protection from coronary artery disease (p.S447*; minor-allele frequency, 9.9%; odds ratio, 0.94; P=2.5×10(-7)).
|
26934567 |
2016 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We speculated that the mutation D151N in LPL gene might be associated with FCHL and early-onset coronary heart disease in this family.
|
31599081 |
2020 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we show that the LPL Asp9Asn mutation is in non-random association with a T G substitution at position -93 of the proximal promoter region and that the combined -93G/Asn9 genotype predisposes to decreased HDL-C levels and an increased risk of CAD.
|
9550358 |
1998 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic variants of the LPL gene are common and might affect risk of CAD.
|
10091829 |
1999 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure (ie, APOA1 G(-75)A, ABCA1 C(-477)T, ABCA1 G1051A, APOC3 T3206G, APOE Arg158Cys, LIPC C(-514)T, LPL Asn291Ser and LPL Ser447Stop).
|
15657615 |
2005 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Hyperlipidemia is a risk factor of arteriosclerosis, stroke, and other coronary heart disease, which has been shown to correlate with single nucleotide polymorphisms of genes essential for lipid metabolism, such as lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5).
|
29425239 |
2018 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common genetic variants of lipoprotein lipase and apolipoproteins AI-CIII that relate to coronary artery disease: a study in Chinese and European subjects.
|
9719626 |
1998 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among Mexican-Americans, homozygosity for LPL haplotype 1 was protective against coronary artery disease (OR = 0.50, 95% CI 0.27-0.91).
|
12865761 |
2004 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The LPL S447X single nucleotide polymorphism (cSNP) has been associated with decreased triglycerides (TG), increased high density lipoprotein cholesterol, and a decreased risk of coronary artery disease (CAD), which may occur independently of its beneficial lipid changes.
|
11683775 |
2001 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Allelic frequencies of polymorphic variants at the lipoprotein lipase gene locus on chromosome 8 have been measured in subjects with premature coronary heart disease and/or dyslipidemia.
|
8907213 |
1995 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No CAD or control subjects were identified with the LPL(Pro207-->Leu) or LPL(Asp250-->Asn) alleles.
|
9627528 |
1998 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The lipoprotein lipase (LPL) gene has been investigated extensively in linkage studies and in studies of its association with lipid profiles and coronary artery disease (CAD), and this gene has also been reported to have an association with hypertension.
|
15253101 |
2004 |