|
Allergic rhinitis (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> The anti-inflammatory effects of miR-146a on AR might exert through the inhibition of the toll-like receptor 4 (TLR4)/TRAF6/NF-κB signaling pathway to some extent.
|
31361168 |
2019 |
|
Postoperative delirium
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
<b>Conclusion:</b> The dysregulation of preoperative miR-146a and miR-181c in CSF and serum was associated with the development and severity of POD.
|
28690539 |
2017 |
|
Diabetic Angiopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> These results suggest that miR-146a-5p is involved in the regulation of HG-induced endothelial inflammation via modulation of IRAK-1; indicating that miR-146a-5p may be a novel target for the treatment of diabetic vascular complications.
|
28824448 |
2017 |
|
Hyperglycemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
<b>Objective:</b> It was demonstrated that inflammation and oxidative stress induced by hyperglycemia were closely associated with alteration of miR-146a.
|
29867484 |
2018 |
|
Sneezing
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
<b>Results:</b> The expression level of miR-146a in AR nasal mucosa was significantly decreased. miR-146a mimic markedly attenuated sneezing and nasal rubbing events, decreased the levels of ovalbumin-specific IgE as well as mastocyte- and basophil-related inflammatory cytokines, reduced inflammatory cells, affected the T-helper 2-released cytokines.
|
31361168 |
2019 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> We showed that the expression of miR-146a is reduced in the Ly6C<sup>high</sup> subset of CIA mice and in the analogous monocyte subset (CD14<sup>+</sup>CD16<sup>-</sup>) in humans with RA as compared with healthy controls.
|
30613275 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
<i>Conclusion:</i> A panel of miRNAs with miR-146a, miR-222 and miR-223 could be used as potential noninvasive biomarkers for early detection of AD.
|
28123597 |
2017 |
|
Superficial ulcer
|
0.020 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i> delivery of miR-146a to Ly6C<sup>high</sup> monocytes, and not to Ly6C<sup>low</sup> monocytes, rescues bone erosion in miR-146a<sup>-/-</sup> arthritic mice and reduces osteoclast differentiation and pathogenic bone erosion in CIA joints of miR-146a<sup>+/+</sup> mice, with no effect on inflammation.
|
30613275 |
2018 |
|
Skin Erosion
|
0.020 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i> delivery of miR-146a to Ly6C<sup>high</sup> monocytes, and not to Ly6C<sup>low</sup> monocytes, rescues bone erosion in miR-146a<sup>-/-</sup> arthritic mice and reduces osteoclast differentiation and pathogenic bone erosion in CIA joints of miR-146a<sup>+/+</sup> mice, with no effect on inflammation.
|
30613275 |
2018 |
|
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
5-AzadC-induced miR-140-5p and miR-146a upregulation was observed in OA chondrocytes and synoviocytes.
|
31077718 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor and peritumoral miR146a expression was negatively correlated with frequency of seizures and the density of activated microglial cells.
|
25986346 |
2015 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Metastasis-related miRNAs are overexpressed in CTCs and corresponding plasma; miR-21 expression levels highly correlate in CTCs and plasma; and miR-21, miR-146a, and miR-210 are valuable plasma biomarkers for discriminating patients from healthy individuals.
|
27197674 |
2016 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NSCLC cells were infected with mimics or inhibitor to overexpress or downregulate miR-146a level.
|
28678319 |
2017 |
|
Cardiovascular morbidity
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease.
|
29186297 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sepsis was induced in mice via cecal ligation and puncture (CLP) and an intravenous injection of a complex of miR-146a-expressing plasmid and polyethyleneimine.
|
30700845 |
2019 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sepsis was induced in mice via cecal ligation and puncture (CLP) and an intravenous injection of a complex of miR-146a-expressing plasmid and polyethyleneimine.
|
30700845 |
2019 |
|
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gastric cancer is one of the most significant reasons for cancer-related death. miR-146a is one of the dysregulated factors associated with gastric tumorigenesis.
|
30880764 |
2019 |
|
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gastric cancer is one of the most significant reasons for cancer-related death. miR-146a is one of the dysregulated factors associated with gastric tumorigenesis.
|
30880764 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
miR-146a suppresses invasion of pancreatic cancer cells.
|
20124483 |
2010 |
|
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MiR-146a intensely expressed in RA synovium in comparison to OA.
|
20840794 |
2010 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-146a (miR-146a) is a negative regulator of immune and inflammatory responses, and is strongly expressed in rheumatoid arthritis (RA) synovium and peripheral blood mononuclear cells (PBMCs).
|
21425254 |
2011 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice.
|
21555486 |
2011 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice.
|
21555486 |
2011 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice.
|
21555486 |
2011 |
|
T-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-146a downregulates NFκB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma.
|
21610143 |
2011 |