B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.
|
23169640 |
2012 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas.
|
22797699 |
2012 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
To further explore the biological significance of the spreading of γ-herpesvirus-encoded miRs on carcinogenesis, we focused on KSHV-miR-K12-11 (miR-K12-11) that is unique in having an identical seed sequence with the oncomiR hsa-miR-155, implicated in B cell lymphomas development.
|
27248822 |
2016 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
B-cell infection by EBV induces the expression of several cellular microRNAs (miRNAs), most notably miR-155, which is overexpressed in many tumors and can induce B-cell lymphomas when overexpressed in animals.
|
20844043 |
2010 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
As a oncogenic biomarker of B-cell lymphoma, serum miR155 was related to lymphoma progression through modulating PD-1/PD-L1-mediated interaction with CD8+T cells of tumor microenvironment, indicating the sensitivity of B-cell lymphoma to PD-L1 blockade.
|
30925928 |
2019 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
After stratification by histological subtype, low-expression levels of miR-155 and miR-150 were both associated with shorter progression-free survival only in primary cutaneous marginal zone B-cell lymphomas cases (log-rank test, P<0.05).
|
22936066 |
2013 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
By using a sensitive and quantitative assay, we find that clinical isolates of several types of B cell lymphomas, including diffuse large B cell lymphoma (DLBCL), have 10- to 30-fold higher copy numbers of miR-155 than do normal circulating B cells.
|
15738415 |
2005 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Unsupervised nonhierarchical clustering of the viral and cellular microRNAome distinguished non-EBV-associated from EBV-associated samples and identified a separate group of EBV-associated pCNS PTLD that displayed reduced levels of B cell lymphoma associated oncomiRs such as hsa-miR-155, -21, -221 and the hsa-miR-17-92 cluster.
|
25130212 |
2014 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, our data indicate an oncogenic role for miR-155 in B-cell lymphoma which involves targeting the tumor suppressor NIAM.
|
26497687 |
2016 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas.
|
19890474 |
2009 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results point to an NF-κB-dependent mechanism for down-regulation of CD10 in B-cell lymphoma: namely, that increased NF-κB activity leads to increased miR-155, which results in decreased PU.1, and consequently reduced CD10 mRNA and protein.
|
20947507 |
2011 |
B-Cell Lymphomas
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MicroRNA-155 (miR-155) is highly expressed in many cancers such as B cell lymphomas and myeloid leukemia and inflammatory disorders such as rheumatoid arthritis, atopic dermatitis, and multiple sclerosis.
|
24362029 |
2014 |
B-Cell Lymphomas
|
0.100 |
Biomarker
|
group |
BEFREE |
More recently, upregulation of oncogenic miR-155 and its precursor pre-miR-155 was demonstrated in both Rev-T-infected chicken embryo fibroblast cultures and Rev-T-induced B-cell lymphomas.
|
28113043 |
2017 |