|
Adenocarcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
High-grade human ovarian adenocarcinomas that accumulate miR-200a have low concentrations of p38α and an associated oxidative stress signature.
|
22101765 |
2011 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Moreover, a detailed statistical analysis revealed that, in adenocarcinoma and in the early stage of carcinomas (pathologic stage I/II), expression of miR-200a was higher in the AKT2+ group compared with the AKT1+ group, and these differences were statistically significant (P=.0334 and P=.0239, respectively).
|
27189341 |
2016 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It was noteworthy that miR-200a was significantly down-regulated in gastric adenocarcinoma samples (P = .04) but was up-regulated in esophageal adenocarcinoma samples (P = .001).
|
23456798 |
2013 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression Levels of microRNAs miR-93 and miR-200a in Pancreatic Adenocarcinoma with Special Reference to Differentiation and Relapse-Free Survival.
|
30537722 |
2019 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our study demonstrated that miR-200a regulates the apoptosis of hepatocyte in ALD by directly target ZEB2, both of which could serve as new therapeutic targets for ALD.
|
29251244 |
2018 |
|
Adult Liver Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR and Western blot results showed that low expressed miR-200a and highexpressed ASPH were found in liver cancer cell lines.
|
29736205 |
2018 |
|
Adult Liver Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> These findings indicate that miR-200a regulates the proliferation, migration and invasion of HCC cells by targeting Foxa2, suggesting that miR-200a may function as a potential therapeutic molecular for the diagnosis and treatment of the liver cancer.
|
28367241 |
2017 |
|
Adult Liver Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here, we sought to investigate the role of miR-200a in regulation of EMT phenotype of liver cancer stem cells (LCSCs).
|
25412960 |
2015 |
|
Adult Liver Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In the subgroup analysis, expression of miR-200a and miR-429 was associated with survival of breast cancer and liver cancer, respectively.
|
31558294 |
2019 |
|
Adult Meningioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To identify how miR-200a contributes to meningioma pathogenesis at the molecular level, we used a comparative protein profiling approach using Gel-nanoLC-MS/MS and identified approximately 130 dysregulated proteins in miR-200a-overexpressing meningioma cells.
|
24858044 |
2015 |
|
Adult Meningioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This reveals a previously unrecognized signaling cascade involved in meningioma tumor development and highlights a novel molecular interaction between miR-200a and Wnt signaling, thereby providing insights into novel therapies for meningiomas.
|
19703993 |
2009 |
|
Alcohol abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
Functional enrichment of the miR-183C and miR-200a/b family target genes, revealed neuroinflammatory pathways networks involved in TLR4 signaling and alcohol abuse.
|
30374194 |
2018 |
|
Alcoholic Liver Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
MicroRNA-200a induces apoptosis by targeting ZEB2 in alcoholic liver disease.
|
29251244 |
2018 |
|
Alzheimer's Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
An increased level of miR-200a-3p and a decreased level of SIRT1 in the hippocampus of APPswe/PS delta E9 mice (a model for AD) were observed.
|
29358553 |
2017 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
In addition, cell apoptosis was detected using flow cytometry, and related protein levels were measured using Western blot and enzyme-linked immunosorbent assay (ELISA) techniques. miR-200a-3p was confirmed to be depressed in microarray miRNA profile analysis <i>in vitro</i> and <i>in vivo</i>, suggesting that miR-200a-3p is a potential biomarker of AD.
|
31379578 |
2019 |
|
Alzheimer's Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown that miR-200a is markedly deregulated in various neurodegenerative disorders including Alzheimer's disease (AD), Multiple Sclerosis (MS) and PD.
|
29936262 |
2018 |
|
Amyloidosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis through down-regulation of SIRT1 in Alzheimer's disease.
|
29358553 |
2017 |
|
Amyloidosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation <i>via</i> Coregulating BACE1 and PRKACB.
|
31379578 |
2019 |
|
Anaplastic thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, miR-200a-3p was directly bound to MALAT1 and its inhibition reversed the inhibitory effect of MALAT1 knockdown on progression of ATC.
|
31500506 |
2019 |
|
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This evidence supports the potential that miR-200a represents a new approach to treating asthma.
|
30423573 |
2018 |
|
Asthma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Collectively, it was demonstrated that the effect of IRN on asthma relied on the up-regulation of miR-200a, which then deactivated FOXC1/NF-κB pathway.
|
31733831 |
2020 |
|
Basal-Like Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We show that EPHA2 expression is correlated with poor survival specifically in basal-like breast cancer and that its expression is repressed by miR-200a through direct interaction with the 3'UTR of EPHA2.
|
26088362 |
2015 |
|
Benign Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study, miR-187 and miR-200a were found to be expressed at higher levels in ovarian cancers than in benign tumors.
|
21725366 |
2012 |
|
Benign neoplasm of thyroid gland
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To address this, hsa-miR-200a-5p, a miRNA, was selected and detected in PTC patients by in situ hybrization with benign thyroid tumor with papillary hyperplasia as a control, and the differential expression of hsa-miR-200a-5p between fresh PTC tissues and control was detected by qRT-PCR.
|
30005075 |
2018 |
|
Benign Ovarian Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
With a sensitivity of 83 % and a specificity of 100 %, the combination of miR-200a, miR-200b and miR-200c could differ between malignant and benign ovarian tumors (p = 0.0001).
|
27753009 |
2016 |