MIR34A, microRNA 34a, 407040

N. diseases: 428; N. variants: 5
Disease: Osteosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.100 Biomarker disease BEFREE Specifically, in this study, using systematic observations of multi-drug sensitive (G-292 and MG63.2) and resistant (SJSA-1 and MNNG/HOS) osteosarcoma (OS) cell lines, we showed that miR-34a-5p promotes the multi-drug resistance of OS through the receptor tyrosine kinase CD117, a direct target of miR-34a-5p. 27056900 2016
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.100 AlteredExpression disease BEFREE Mechanistically, we found that overexpression of miR-34a led to decreased Eag1 expression in osteosarcoma cells while inhibition of miR-34a increased Eag1 expression. 23569431 2013
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.100 Biomarker disease BEFREE And there are other putative miR-34a target genes beside c-Met which could potentially be key players in the development of osteosarcoma. 22457788 2012
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.100 AlteredExpression disease BEFREE A genetically engineered microRNA-34a prodrug demonstrates anti-tumor activity in a canine model of osteosarcoma. 30596759 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.100 GeneticVariation disease BEFREE A G>A variation in the pre‑miR‑34a coding region was found to be associated with higher OS morbidity. 25242229 2014
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.100 Biomarker disease BEFREE Our findings find out an important function of miR-34a as a novel tumor-suppressor in osteosarcoma pathogenesis through inhibition of DUSP1. 29312491 2017