ASIC1, acid sensing ion channel subunit 1, 41

N. diseases: 52; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 Biomarker disease BEFREE Experiments were performed in cultured FLS from wild-type (WT) and ASIC3-/- mice, ASIC1-/- mice, and people with rheumatoid arthritis. 24923411 2014
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.010 Biomarker disease BEFREE While blockade of ASIC1 through amiloride, a potassium sparing diuretic that is currently licensed for hypertension and congestive cardiac failure, showed neuroprotective and myeloprotective effects in experimental models of multiple sclerosis, this strategy remains untested in patients with multiple sclerosis. 23365093 2013
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.010 Biomarker disease BEFREE While blockade of ASIC1 through amiloride, a potassium sparing diuretic that is currently licensed for hypertension and congestive cardiac failure, showed neuroprotective and myeloprotective effects in experimental models of multiple sclerosis, this strategy remains untested in patients with multiple sclerosis. 23365093 2013
CUI: C0221505
Disease: Lesion of brain
Lesion of brain 		0.010 AlteredExpression group BEFREE First, we assessed ASIC1 expression in chronic brain lesions from post-mortem of patients with progressive multiple sclerosis to identify the target process for neuroprotection. 23365093 2013
CUI: C0282488
Disease: Interstitial Cystitis
Interstitial Cystitis 		0.010 Biomarker disease BEFREE We assayed mRNA expression of the TRP family of channels and ASIC1 in bladder tissue from patients with interstitial cystitis. 23727186 2013
CUI: C0600040
Disease: Chronic interstitial cystitis
Chronic interstitial cystitis 		0.010 Biomarker disease BEFREE We assayed mRNA expression of the TRP family of channels and ASIC1 in bladder tissue from patients with interstitial cystitis. 23727186 2013
CUI: C0751964
Disease: Multiple Sclerosis, Primary Progressive
Multiple Sclerosis, Primary Progressive 		0.010 Biomarker disease BEFREE Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride. 23365093 2013
CUI: C1095979
Disease: Progressive multiple sclerosis
Progressive multiple sclerosis 		0.010 AlteredExpression disease BEFREE First, we assessed ASIC1 expression in chronic brain lesions from post-mortem of patients with progressive multiple sclerosis to identify the target process for neuroprotection. 23365093 2013
CUI: C0154723
Disease: Migraine with Aura
Migraine with Aura 		0.010 Biomarker disease BEFREE Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura. 23109150 2012
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.010 Biomarker disease BEFREE Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration. 19561078 2009
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.010 Biomarker disease BEFREE Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration. 19561078 2009
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.010 Biomarker disease BEFREE Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism. 18658163 2008
CUI: C0022116
Disease: Ischemia
Ischemia 		0.010 Biomarker phenotype LHGDN Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a. 17984098 2008
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.010 Biomarker group LHGDN Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a. 17984098 2008
CUI: C0010606
Disease: Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma 		0.010 AlteredExpression disease LHGDN Identification of acid-sensing ion channels in adenoid cystic carcinomas. 17324378 2007
CUI: C0024408
Disease: Machado-Joseph Disease
Machado-Joseph Disease 		0.010 Biomarker disease LHGDN Research on screening and identification of proteins interacting with ataxin-3. 15952105 2005
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.020 AlteredExpression disease BEFREE Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer 30583668 2018
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.020 AlteredExpression disease BEFREE Down-regulation of ASIC1 suppressed gastric cancer via inhibiting autophagy. 28111260 2017
CUI: C0003467
Disease: Anxiety
Anxiety 		0.020 Biomarker disease BEFREE Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. 25913301 2015
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 Biomarker disease BEFREE Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme. 24100685 2013
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.020 Biomarker disease BEFREE However, it has not been determined whether Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates ASIC1 in glioblastoma multiforme (GBM). 24100685 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 AlteredExpression disease BEFREE Using quantitative real time PCR, we have shown higher expression of ASIC1, alphaENaC, and gammaENaC in D54-MG human glioblastoma multiforme cells compared with primary human astrocytes. 19561078 2009
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.020 AlteredExpression disease BEFREE Using quantitative real time PCR, we have shown higher expression of ASIC1, alphaENaC, and gammaENaC in D54-MG human glioblastoma multiforme cells compared with primary human astrocytes. 19561078 2009
CUI: C0003467
Disease: Anxiety
Anxiety 		0.020 GeneticVariation disease BEFREE Although the ACCN2 gene may play a role in rodent fear conditioning, we could not detect association with genetic risk shared among human anxiety spectrum disorders. 18349698 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.030 Biomarker group BEFREE We previously reported that ASIC1 in pulmonary artery smooth muscle cells (PASMC) contribute to pulmonary vasoreactivity and vascular remodeling during the development of chronic hypoxia (CH)-induced pulmonary hypertension. 31169471 2019