|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Mental deterioration
|
0.200 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
Mental deterioration
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
High CSF p-tau(231) levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD.
|
12196665 |
2002 |
|
Mental deterioration
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
This study evaluated the sensitivity and specificity of the cerebrospinal fluid (CSF) levels of tau-protein, amyloid-beta-peptide 1-42 (Abeta1-42), ApoE-genotype and the degree of cognitive decline as diagnostic markers for Alzheimer's disease (AD).
|
14523627 |
2003 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities.
|
15601849 |
2005 |
|
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
We observed that cognitive decline and the development of PD dementia are strongly associated (p = 10(-4)) with the inversion polymorphism containing MAPT.
|
17683088 |
2007 |
|
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Aggregation and accumulation of the microtubule-associated protein tau are associated with cognitive decline and neuronal degeneration in Alzheimer's disease and other tauopathies.
|
22039833 |
2011 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Tangle-predominant dementia (TPD) patients exhibit cognitive decline that is clinically similar to early to moderate-stage Alzheimer disease (AD), yet autopsy reveals neurofibrillary tangles in the medial temporal lobe composed of the microtubule-associated protein tau without significant amyloid-beta (Aβ)-positive plaques.
|
22802095 |
2012 |
|
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
MAPT haplotype and COMT genotype were associated with measures of memory and attention, respectively, over the entire follow-up period, but not with the overall rate of cognitive decline.
|
22344634 |
2012 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
It is characterized by the accumulation of amyloid β peptides and abnormally phosphorylated tau proteins that are associated with cognitive decline and dementia.
|
24905038 |
2015 |
|
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Finally we highlight the clinical significance of this pathology by demonstrating that the MAPT haplotypes affect the rate of cognitive decline in a large cohort of patients with Huntington's disease.
|
25953777 |
2015 |
|
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Here, we investigate whether APOE, COMT, or MAPT influence the rate of cognitive decline in PD patients.
|
27061069 |
2016 |
|
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Older age was related to cognitive decline in visuoconstruction (p = 0.005) and social cognition (p = 0.026) in MAPT.
|
27358337 |
2016 |
|
Mental deterioration
|
0.200 |
AlteredExpression
|
phenotype |
BEFREE |
Since the BBB ensures the clearance of tau proteins from brain, we hypothesize that the dysfunction of the BBB throughout the disease progression may possibly cause the concurrent increase of CSF tau proteins levels in PD, which could be irrespective of cognitive decline.
|
27934563 |
2017 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by the formation of amyloid beta (Aβ) or tau protein aggregates, the hallmark of cognitive decline.
|
28769761 |
2017 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Tauopathies such as Alzheimer's disease and frontotemporal lobe degeneration (FTLD-tau) dementia, characterized by pathologic aggregation of the microtubule-associated tau protein and formation of neurofibrillary tangles, have been linked to neurodegeneration and cognitive decline.
|
28523532 |
2017 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) with increasing evidence implicating neuropathological tau protein in this process.
|
28196395 |
2017 |
|
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Cognitive decline in ScreeLing phonology (p = 0.046) and letter fluency (p = 0.046) were predictive for conversion to non-fluent variant PPA, and decline on categorical fluency (p = 0.025) for an underlying MAPT mutation.
|
29627938 |
2018 |
|
Mental deterioration
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings suggest that early GMV loss in MAPT H1H1 PD patients increases their risk to develop cognitive decline.
|
29899731 |
2018 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins.
|
30123104 |
2018 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
To define whether amyloid β protein deposits or tau protein lesions appear first during normal brain aging, we performed an immunohistological study on serial sections from 105 autopsy brains (age range: 40-104 years) from patients free of clinical signs of cognitive decline, using anti-tau (AT8) and anti-amyloid (4G8) antibodies in the hippocampus, entorhinal cortex, inferior temporal cortex (Brodmann area 20), prefrontal cortex (Brodmann area 9), occipital cortex (Brodmann areas 17 and 18), and in the brainstem.
|
29107845 |
2018 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Specifically, factors related to poor glucose metabolism, insulin resistance, inflammation, comorbid depression, micro-/macrovascular complications, adipokines, neurotrophic molecules and Tau protein presented significant changes in diabetic patients with cognitive decline.
|
29484146 |
2018 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Perioperative varenicline attenuated the cognitive decline and associated tau protein mislocalization, DNA damage and neuronal apoptosis.
|
30273594 |
2018 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline associated with the deposition of amyloid-β (Aβ) plaques, hyperphosphorylation of tau protein, and neuronal loss.
|
31427644 |
2019 |
|
Mental deterioration
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
In Alzheimer's disease, the density and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker.
|
30810314 |
2019 |