|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Finally, we review the connections between disruptions in PAR-1/MARK function and Alzheimer's disease and cancer.
|
28236972 |
2017 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
This means that proviral insertions mark genes contributing to tumorigenesis, as was demonstrated by the identification of numerous proto-oncogenes in retrovirally induced tumors in the past.
|
12665053 |
2003 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CCR5 was predicted to participate in RA by regulating the MARK pathway.
|
31066041 |
2019 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
On the mark: genetically engineered immunotherapies for autoimmunity.
|
31563849 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MicroRNA-23a promotes colorectal cancer cell migration and proliferation by targeting at MARK1.
|
31281935 |
2019 |
|
Down Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We compared levels of circulating TTV in 1,813 participants of the MARK-AGE project, including human models of delayed (offspring of centenarians - GO) and premature (Down syndrome - DS) immunosenescence.
|
31838498 |
2019 |
|
Ketosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The useful mnemonics for causes of high anion gap metabolic acidosis are the classic MUDPILES (representing Methanol, Uraemia, Diabetes, Paraldehyde, Iron (and Isoniazid), Lactate, Ethylene glycol, and Salicylate) and the more recently proposed GOLD MARK (Glycols [ethylene and propylene], Oxoproline, l-lactate, d-lactate, Methanol, Aspirin, Renal failure, and Ketoacidosis) as causes of the anion gap metabolic acidosis were all ruled out.
|
30578759 |
2019 |
|
Sacculation
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that Mark1-mediated fibroblast activation induces AECI flattening and thereby regulates distal lung sacculation.
|
31719161 |
2019 |
|
Metabolic Syndrome X
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Capacity adiposity indices to identify metabolic syndrome in subjects with intermediate cardiovascular risk (MARK study).
|
30682054 |
2019 |
|
Complete Trisomy 21 Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We compared levels of circulating TTV in 1,813 participants of the MARK-AGE project, including human models of delayed (offspring of centenarians - GO) and premature (Down syndrome - DS) immunosenescence.
|
31838498 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
MicroRNA-23a promotes colorectal cancer cell migration and proliferation by targeting at MARK1.
|
31281935 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Treatment with the selective MARK/SIK inhibitor MRT199665 caused apoptosis and conferred chemosensitivity in MEF2C-activated human AML cell lines and primary patient specimens, but not those lacking MEF2C phosphorylation.
|
29431698 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have shown that miR-451 regulates downstream molecules including AMPK/CAB39/MARK and mTOR to determine the balance between rapid proliferation and invasion in response to metabolic stress in the harsh tumor microenvironment.
|
30286133 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results showed that inhibiting LKB1 or MARK1 in NSCLC increases the collagen fiber alignment and captures outward alignment vectors from the tumor spheroid, corresponding to high invasiveness of LKB1 mutant cancer cells.
|
28045069 |
2017 |
|
Hemorrhoids
|
0.010 |
Biomarker
|
disease |
BEFREE |
And on page 33, the last sentence should read as follows: "As reflected in the revisions to MUD PILES and in the newer GOLD MARK acronym, the osmol gap has become more valuable in differential diagnosis of metabolic acidosis with an elevated anion gap consequent to an expanding array of toxic ingestions (methanol, propylene glycol, ethylene glycol, and diethylene glycol), which may accompany pyroglutamic acid-oxoproline."
|
28322687 |
2017 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, unbiased mass spectrometry was used to identify the microtubule affinity-regulating kinase family (MARKs) as activated and insoluble in a neuronal culture PD model.
|
28522732 |
2017 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings implicate MARKs early in synucleinopathy pathogenesis and as potential therapeutic drug targets.<b>SIGNIFICANCE STATEMENT</b> Neurodegenerative diseases are diagnosed definitively only in postmortem brains by the presence of key misfolded and aggregated disease proteins, but cellular processes leading to accumulation of these proteins have not been well elucidated.
|
28522732 |
2017 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Induction of MDA-9/syntenin in melanoma was found to occur in a thrombin-independent signaling pathway and involves the PAR-1/c-Src/Rho GTPases Rac1 and Cdc42/c-Jun N-terminal kinase axis resulting in the activation of paxillin, NF-κB, and matrix metalloproteinase-2 (MMP-2).
|
25505176 |
2015 |
|
Neoplasm Metastasis
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
MARK1 phosphorylation of DIXDC1 is required for its localization to focal adhesions and ability to suppress metastasis in mice.
|
25042806 |
2014 |
|
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Resistin-induced SDF-1 upregulation by activation of TLR4, p38 MARK and NF-κB may explain a new role of resistin in the link of obesity and gastric cancer.
|
24929539 |
2014 |
|
Papillary thyroid carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CYP24A1 overexpression is a poor prognostic indicator for PTC and may reflect BRAF(V600E) mutation and MARK activation.
|
24382015 |
2014 |
|
Mental disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results demonstrate the ability of infant-caregiver interactions to epigenetically mark genes known to play a prominent role in cognition and psychiatric disorders within the mPFC.
|
23751776 |
2013 |
|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results demonstrate the ability of infant-caregiver interactions to epigenetically mark genes known to play a prominent role in cognition and psychiatric disorders within the mPFC.
|
23751776 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
This will include the (1) DRD4 gene associated with attentiondeficit/ hyperactivity disorder, located in a locus that underwent a positive selection; the (2) GABRB2 gene, a gene associated with schizophrenia and recently reported as the target of a positive selection; (3) MARK1, a candidate gene for autism that was reported as displaying a signature of adaptative evolution in the human lineage, and (4) the ADH and ALDH2 genes which are associated with alcoholism, and for which evidence of positive selection was identified in the human lineage since the divergence between humans and chimpanzees.
|
20166940 |
2010 |
|
Attention deficit hyperactivity disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This will include the (1) DRD4 gene associated with attentiondeficit/ hyperactivity disorder, located in a locus that underwent a positive selection; the (2) GABRB2 gene, a gene associated with schizophrenia and recently reported as the target of a positive selection; (3) MARK1, a candidate gene for autism that was reported as displaying a signature of adaptative evolution in the human lineage, and (4) the ADH and ALDH2 genes which are associated with alcoholism, and for which evidence of positive selection was identified in the human lineage since the divergence between humans and chimpanzees.
|
20166940 |
2010 |