Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Mannose binding lectin (MBL) generally plays a protective role during viral infection, yet MBL-mediated complement activation promotes Ross River virus (RRV)-induced inflammatory tissue destruction, contributing to arthritis and myositis.
|
29324290 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition to activating the complement, MBL can induce cytokine production and contribute to a deleterious inflammatory response with severe A(H1N1)pdm09 virus infection.
|
29273833 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
However, this effect was specific for H9 cells since MBL did not neutralize cell line-adapted virus infection of PBMCs, HIV PI infection of the GHOST cell line, or VSV pseudotyped with HIV gp160 from cell line-derived virus or PI.
|
15117456 |
2004 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Host genetic factors such as MBL2 gene polymorphisms cause defects in the polymerization of MBL protein and result in a functional deficiency and/or in low serum levels that can influence susceptibility to various viral infections.
|
30482213 |
2018 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In subgroup analyses occurrence of severe herpes virus infections in particular was associated with significantly lower mannose-binding lectin levels (P=0.02).
|
20418242 |
2010 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Since single-nucleotide polymorphisms (SNPs) in the gene encoding MBL (mbl2) alter the level of functional MBL, we hypothesized that mbl2 genotypes are a determinant of HBV persistence or recovery from viral infection.
|
15994813 |
2005 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To investigate the roles of inherited polymorphisms in the MBL2 gene and exposure to viral infection in the development of a range of adverse pregnancy outcomes, including birthweight < 10th percentile (small-for-gestational age, SGA), antepartum hemorrhage (APH), pregnancy-induced hypertensive disorders (PIHD), and preterm birth (PTB).
|
21171930 |
2011 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Unlike several other viral envelopes to which MBL can bind, both recombinant and plasma-derived human MBL directly inhibited SARS-S-mediated viral infection.
|
20573835 |
2010 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, low MBL levels pre-transplant predisposed patients to sepsis, fungal and viral infection.
|
19430499 |
2010 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, pre-transplant MBL levels would be important in predicting susceptibility to viral infections and mortality and might be considered a biomarker to be included in the pre-transplantation risk assessment.
|
31706269 |
2019 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic variants in the immunomodulatory gene mannose-binding lectin 2 (MBL2), were associated with risk, severity, and frequency of viral infections.
|
17380431 |
2007 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MBL2 gene polymorphisms have been shown to modulate susceptibility or protection in many viral diseases.
|
18361938 |
2008 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Carriers of MBL gene variant alleles (MBLva) have decreased plasma concentrations of MBL and increased susceptibility to bacterial and viral infections.
|
18831943 |
2008 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Due to the role of KIR and low or deficient MBL haplotypes in viral infections, these genetic markers could be considered as indicators of a need for CMV prophylaxis at younger age and therefore increased probability of longer lifespan.
|
23302099 |
2013 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Some human gene variants reduce MBL activity thereby predisposing the host to bacterial and viral infections.
|
24321858 |
2014 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Mannan-binding lectin (MBL) - associated serine protease 2 (MASP-2) co-activates the lectin pathway of complement in response to several viral infections.
|
27588826 |
2016 |