Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data show that MBL insufficiency plays an important role in the susceptibility of critically ill patients to the development and progression of sepsis and confers a substantial risk of fatal outcome.
|
14593599 |
2003 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Mannose-binding lectin (MBL) is an innate immune protein with strong biologic plausibility for protecting against influenza virus-related sepsis and bacterial co-infection.
|
31139182 |
2019 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether polymorphisms in the MBL2 gene and the serum level are associated with the severity and prognosis of sepsis.
|
19891773 |
2009 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Generally, sepsis was associated with low serum MBL and low ficolin-2 concentrations on admission.
|
26850322 |
2016 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients homozygous for wild-type MBL2 had a significantly reduced risk of septicaemia during the ASCT procedure compared with patients carrying variant MBL2: Odds Ratio (OR) 0.19 (95% CI: 0.04-0.77), (P=0.02) in multivariate analysis.
|
16953214 |
2006 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MBL gene polymorphism was associated with increased frequency of clinical sepsis particularly with early neonatal sepsis and also with higher Tollner sepsis scores and increased frequency of patent ductus arteriosus in infants.
|
20453525 |
2010 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subsequently, data were reassessed to extend previous MBL and sepsis associations, with adjustment for known outcome predictors.
|
18611155 |
2008 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A SNP in MBL2 and MPO gene was associated with septicemia and a SNP in the gene CYP2C8 was strongly associated with ONJ.
|
21883476 |
2012 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the first study, the median MBL level was decreased in newborns with confirmed sepsis (170 μg/l) compared with newborns without sepsis (1450 μg/l).
|
20488866 |
2010 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified.
|
25969530 |
2015 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Twenty-nine studies addressing four MBL polymorphisms (-550G/C, -221G/C, structure variant A/O, Gly54Asp) were analysed for susceptibility to sepsis and one study for sepsis-related mortality.
|
24398289 |
2014 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, low MBL levels pre-transplant predisposed patients to sepsis, fungal and viral infection.
|
19430499 |
2010 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, we found indications of a reduced occurrence of septicaemia in patients with wild-type compared with variant MBL2.
|
16827883 |
2006 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No relationship was found between MBL genotype and the risk of nosocomial sepsis or pneumonia, even after correction for birth-weight, perhaps because of an insufficient correlation between genotype and the concentration of functional MBL.
|
18031556 |
2008 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Median MBL function was lower in sepsis patients (0.18 U microL(-1)) than in controls (0.48 U microL(-1), P<0.001).
|
17064281 |
2006 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate the possible associations between polymorphisms in CHIT1, MBL2 and sepsis in adult patients treated with high-dose chemotherapy for AML.
|
20331735 |
2010 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The variant alleles in the mannose binding lectin-2 (MBL-2) gene have been associated with MBL deficiency and increased susceptibility to sepsis.
|
17133182 |
2007 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of MBL2 gene polymorphism in sepsis incidence.
|
26823854 |
2015 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mannose-binding lectin levels had no association with infection status at admission, or with progression from systemic inflammatory response syndrome to sepsis or septic shock.
|
27820718 |
2017 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of positive bacterial cultures and sepsis but not with altered prevalence of septic shock or decreased 28-day survival.
|
15753758 |
2005 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In patients with infection, variant MBL alleles were associated with increased systemic response (2/15 with localised infection, 10/19 with sepsis and 12/16 with septic shock).
|
15127191 |
2004 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In our cohort of VLBWI, MBL levels were genetically determined, but not associated with gestational age or sepsis in the first 21 days of life.
|
29807983 |
2018 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no association between MBL levels and sepsis risk in the whole cohort.
|
28558032 |
2017 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, in a multivariate analysis MBL insufficiency was associated with the development of the most severe forms of sepsis (P = .007), acute respiratory failure (P = .009), multiorgan dysfunction syndrome (P = .036), intensive care unit admission (P = .020), and death (P = .003).
|
18582923 |
2008 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate MBL demonstrates a variable acute phase response in the clinical setting of sepsis and septic shock.
|
16133991 |
2005 |