|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesized that the tumor-specific midkine (Mdk) promoter could confer transcriptional targeting to oncolytic adenoviruses for effective treatment of malignant mesothelioma.
|
20635326 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the blood MK level is frequently elevated with advance of human carcinomas, decreased after surgical removal of the tumors.
|
19152444 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Antisense oligonucleotides targeting midkine inhibit tumor growth in an in situ human hepatocellular carcinoma model.
|
17303011 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using the minimal promoter region of MK to drive the HSV-TK gene and in vivo electroporation to transduce IL-21 DNA into the tumors produced an efficient gene therapy with improved safety.
|
17695518 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Further study is necessary on the mechanism of MK in gastric tumorigenesis and tumor growth.
|
17484808 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, Ad-MK-E1a injection markedly inhibited KK47 tumor growth.
|
17919690 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Midkine was more intensely expressed in well differentiated tumors (76.9%) than in moderately and poorly differentiated tumors (43.1% and 41.2%, respectively) (P<0.05).
|
16610048 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings show that TSTA systems can enhance PSMA and Mk promoter activities and selectively inhibit PC-3 cell growth in tumors.
|
16800821 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present study was conducted to assess whether midkine (MK), a multifunctional molecule known to stimulate tumor growth, may be involved in the development of endometriosis.
|
15734764 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Yet, stable overexpression of MK in S462 as well as in ST88-14 cells was not sufficient to promote xenograft tumor growth in nude mice.
|
16211240 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The P53-mediated downregulation of the MK promoter activity was stronger in p53-defective tumors than in wild-type p53-bearing tumors.
|
12883697 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To investigate the in vivo effects of MK overexpression on tumor growth, each cell line was injected s.c. and orthotopically into nude mice.
|
14613994 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The expressions of midkine and pleiotrophin mRNA in cervical cancer were higher than those in the normal cervix (MK, 175.59 +/- 63.3 vs 1.00 +/- 0.18 fmol, respectively; PTN, 3.18 +/- 1.25 vs. 0.86 +/- 0.12 fmol, respectively, P < 0.05), and their expressions were not correlated with cervical cancer stage or size of the tumor.
|
12648577 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, considering the ability of antisense MK oligodeoxyribonucleotide to suppress tumour growth of colorectal carcinoma cells in nude mice, as recently reported, the present study suggests that MK is a possible candidate molecular target for therapy for neuroblastomas.
|
12771916 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The matrix forming nf+/- cells may provide a permissive environment, facilitating tumor development, perhaps by providing landscaping factors such as the angiogenic molecules fibroblast growth factor-2, platelet-derived growth factor, endothelial growth factor, vascular endothelial growth factor, and midkine, which have been detected in neurofibromas.
|
12403556 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, there was exclusive or elevated in vitro expression of angiogenic factors IL-8, PDGF-AB, and, to a lesser extent, midkine in cell lines that formed highly vascularized tumors.
|
10842189 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the noncancerous follicular epithelial cells adjacent to neoplasm the signals of MK transcripts were detected very weakly or not at all.
|
11048798 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The rationale for studying MK expression is based on previous reports showing that it transforms 3T3 cells, and that it acts as an autocrine growth factor in Wilm's tumors, and that its overexpression has been associated with worse outcome in bladder carcinoma.
|
10752993 |
2000 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These interesting features of MK led us to examine the MK promoter as a candidate for tumor-specific gene expression.
|
10969765 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overall, median MK expression in invasive tumors that caused death, progressed, or recurred within 12 months was 3-fold higher than that found in the tumors of those patients who were clear of disease at 12 months (P < 0.04).
|
8653688 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest an important role of MK in the development and/or biological behavior of tumors and raised a possibility to use MK as a diagnostic marker.
|
8383007 |
1993 |