|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
MRP1 but not MDR1 is associated with response to neoadjuvant chemotherapy in breast cancer patients.
|
23481629 |
2013 |
|
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
23544013 |
2013 |
|
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
23544013 |
2013 |
|
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, we observed a combinational effect between MDM4 rs4245739 and P53 Arg72Pro variants in attenuating breast cancer risk, highlighting the importance of the P53 tumor suppressor pathway genes during malignant transformation.
|
23793604 |
2013 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The expression status of Klotho, and of the ATP-binding cassette (ABC) transporters MRP1, MDR and breast cancer resistant protein (BCRP), which can cause resistance to anticancer drugs, including irinotecan, was assessed by immunohistochemical analysis in resected surgical specimens of patients with early-stage SCLC.
|
21529984 |
2011 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In line with these results, XI-011 decreased the viability of breast cancer cells expressing low levels of MDMX in a less-efficient manner.
|
21750655 |
2011 |
|
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study evaluated the association of a SNP in human MDM4 (C>T) with age of onset of breast cancer in two independent cohorts.
|
19762336 |
2009 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients.
|
19235593 |
2009 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mechanistically, a high level of p53 protein and a low level of multidrug-resistant protein 1 (MRP1) and breast cancer resistant protein (BCRP) mRNA in KB cells with celecoxib may explain the differential effect of these selective COX-2 inhibitors in KB cells.
|
18202791 |
2008 |
|
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It is unknown, however, whether MDM4 gene alterations play some role in the inherited component of breast cancer susceptibility.
|
18279506 |
2008 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The authors studied the effects of AN-238 and AN-201 on the expression levels of MDR-1, multidrug resistance related protein (MRP-1), and breast carcinoma resistance protein (BCRP) by real-time polymerase chain reaction.
|
16047355 |
2005 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
As a result, the expression of motility related protein-1 (MRP-1/CD9), peripheral myelin protein-22 (PMP-22), and caspase 3 (CASP-3) were down-regulated in M compared to T. We focused especially on MRP-1 and found that the expression status of MRP-1 was significantly inversely associated with stage of disease in 56 cases of breast cancer (P<0.05), and the relapse free survival in 5 years was significantly higher in MRP-1 positive cases than those negative cases (P<0.05).
|
16132579 |
2005 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
A P-glycoprotein- and MRP1-independent doxorubicin-resistant variant of the MCF-7 breast cancer cell line with defects in caspase-6, -7, -8, -9 and -10 activation pathways.
|
15015586 |
2004 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Fresh frozen samples of 45 primary OSCC were investigated for the expression of mdr1 (p-glycoprotein-mediated multi-drug resistance), mrp1 (multi-drug resistance-related protein) and bcrp (breast cancer-related protein), using a reverse transcriptase PCR.
|
15113040 |
2004 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
MRP1 - 3 mRNA was detectable in all breast cancer cell lines and tumor samples.
|
15517899 |
2004 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The results from this study suggest, however, that the expression of survivin, survivin-deltaEx3, survivin-2B, bag-1, galectin-3, bax-alpha and MRP-1 mRNAs cannot be considered as prognostic indicators of disease outcome for patients with breast cancer.
|
14607338 |
2003 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Elevated MRP-1/CD9 expression on tumor cells has been linked to a favorable prognosis in breast cancer, colon cancer, lung cancer, and HNSCC.
|
12966509 |
2003 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The multidrug-resistance (MR) status of camptothecin (CPT) was investigated in colon adenocarcinoma HT29 cells, leukemia K562, and breast carcinoma MCF7 cells expressing P-glycoprotein (Pgp) and/or MR-associated protein (MRP1).
|
12115804 |
2002 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cox regression analysis demonstrated that MRP-1/CD9 status (P = 0.0016) and KAI1/CD82 status (P = 0.0234) were useful indicators for the disease-free survival of breast cancer patients.
|
9736046 |
1998 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Motility related protein 1 (MRP-1/CD9) expression: inverse correlation with metastases in breast cancer.
|
7664290 |
1995 |