|
Multiple Endocrine Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism may occur as part of hereditary syndromes, including multiple endocrine neoplasia types 1 and 2A (MEN1 and MEN2A), hyperparathyroidism-jaw tumor syndrome, and the familial isolated hyperparathyroidism (FIHP).
|
15292357 |
2004 |
|
Multiple Endocrine Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Carney complex (CNC) is a familial multiple neoplasia and lentiginosis syndrome with features overlapping those of McCune-Albright syndrome (MAS) and other multiple endocrine neoplasia (MEN) syndromes like MEN type 1 (MEN 1).
|
15281351 |
2004 |
|
Multiple Endocrine Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism (pHPT) is a common endocrine disease that in more than 95% of cases is sporadic and only in some cases is caused by inherited disorders, isolated or as part of multiple endocrine neoplasia (MEN1 and 2).
|
15754732 |
2004 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It encompasses a spectrum of disorders including multiple endocrine neoplasia types 1 (MEN1) and 2A, hyperparathyroidism-jaw tumour syndrome (HPT-JT), familial hypocalciuric hypercalcaemia (FHH), and familial isolated hyperparathyroidism (FIHP).
|
14985373 |
2004 |
|
Multiple Endocrine Neoplasia
|
0.400 |
Biomarker
|
disease |
LHGDN |
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.
|
12509449 |
2003 |
|
Multiple Endocrine Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interest has focused on Smad3 as a candidate endocrine tumor suppressor gene because 1) it is localized to 15q and 2) it encodes a TGF beta signaling molecule that has been identified as a binding partner of the multiple endocrine neoplasm type 1 gene product menin, itself involved in enteropancreatic and parathyroid neoplasia.
|
12161532 |
2002 |
|
Multiple Endocrine Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumours involving two or more endocrine glands; two major forms, referred to as MEN1 and MEN2, are recognized.
|
11786689 |
2001 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This review presents the newest information on the clinical and molecular genetics of the MENs (MEN 1, MEN 2, and Carney complex), including recommendations for genetic screening, and discusses briefly the related syndromes PJS, CD and VHLD.
|
11407658 |
2001 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multiple endocrine neoplasia type 1Burin from Mauritius: a novel MEN1 mutation.
|
11765051 |
2001 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Multiple endocrine neoplasia type 1Burin from Mauritius: a novel MEN1 mutation.
|
11765051 |
2001 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report a case of synchronous bilateral pituitary adenomas in a patient with multiple endocrine neoplasia type one (MEN1).
|
10871015 |
2000 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Familial hyperparathyroidism may occur as familial isolated hyperparathyroidism (FIHP) or as part of an inherited syndrome, in particular multiple endocrine neoplasia types 1 and 2A (MEN1, MEN2A) and hyperparathyroidism-jaw tumour (HPT-JT) syndrome.
|
10396361 |
1999 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1) and MEN2 syndromes in humans, including medullary thyroid cancer (MTC).
|
9794240 |
1998 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multiple endocrine neoplasia type one (MEN 1) is characterized by tumours of the parathyroid glands, pancreatic islet cells and the anterior pituitary and follows an autosomal dominant pattern of inheritance.
|
8846498 |
1996 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the involvement of the apoptosis-suppressing protein BCL-2 in the gastrin-dependent mechanism of induction of gastric enterochromaffin-like (ECL) cell carcinoids, the endocrine cell of the oxyntic mucosa were immunohistochemically investigated in (a) 10 normogastrinemic subjects with histologically normal gastric mucosa; (b) 22 patients with endocrine cell hyperplasia and affected by hypergastrinemic conditions with different risk of gastric carcinoid development, such as sporadic Zollinger-Ellison syndrome (sZES; n = 9), ZES associated with multiple endocrine neoplasia-1 (MEN-1; n = 4), and atrophic fundal gastritis (AFG; n = 9); (c) 14 patients with ECL gastric carcinoids accounting for a total of 31 tumors investigated.
|
8604810 |
1996 |
|
Multiple Endocrine Neoplasia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The tumorigenesis of neuroendocrine tumours remains poorly understood, although a minority, the familial multiple endocrine neoplasia (MEN 1 and MEN 2), are known to be of uncommon genetic origin.
|
7790993 |
1995 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Seven prolactinoma DNA samples were tested for deletions in the multiple endocrine neoplasia-1 (MEN-1) locus, as well as for rearrangements in the hst gene, a member of the fibroblast growth factor family.
|
8100831 |
1993 |
|
Multiple Endocrine Neoplasia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This probe has been used by others as a landmark to locate MEN1, a locus of predisposition to multiple endocrine neoplasia.
|
2071147 |
1991 |