|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Clinical, cytogenetic and molecular features of acute myeloid leukemia with a MLL-SEPT5 fusion gene are reviewed.
|
23725386 |
2014 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The presence of the MLL gene rearrangements or the age at onset had no impact on the outcome of infant AML.
|
11739161 |
2001 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
FTO is highly expressed in AMLs with t(11q23)/MLL rearrangements, t(15;17)/PML-RARA, FLT3-ITD, and/or NPM1 mutations.
|
28017614 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Involvement of the MLL gene located at chromosome region 11q23 is a frequent occurrence in both acute myelocytic leukemia and acute lymphoblastic leukemia.
|
14580777 |
2003 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although MLL-AF9 caused by the chromosomal translocation t(9;11) has a critical role in acute myeloid leukemia, the molecular pathogenesis is poorly understood.
|
22902925 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This case report helps to better understand the rare but potentially severe impact of KMT2A- FLNA fusions in infants with AML to improve prognostic stratification of therapy and clinical management.
|
28253492 |
2016 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes.
|
9600980 |
1998 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found that DNMT3A and NPM1 mutations and MLL translocations predicted an improved outcome with high-dose induction chemotherapy in patients with AML.
|
22417203 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that the MLL gene rearrangements are similar both in AML that develops de novo and in t-AML.
|
8260707 |
1993 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have recently reported the detection by Southern blot of ALL-1 gene rearrangements in adult patients with acute myeloid leukemia lacking cytogenetic evidence of 11q23 translocations.
|
8016145 |
1994 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Moreover, secondary acute myeloid leukemias (AML) that occur as the result of chemotherapy agents, which are known to inhibit DNA topoisomerase II, often manifest the same MLL abnormalities.
|
8932918 |
1996 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations.
|
8361504 |
1993 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the MLL (11q23) gene in AML are usually related to the morphological phenotype FAB M5.
|
16044313 |
2005 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, in children an increased risk of ALL (odds ratio [OR] = 1.88; 95% confidence interval [CI], 1.16-3.07; P = .010) and AML (OR = 2.74; 95% CI, 1.07-7.01; P = .036) was observed with the MTR 2756 GG genotype; the association was most pronounced for cases with the MLL translocation (OR = 4.90; 95% CI, 1.30-18.45; P = .019).
|
20101025 |
2010 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Presence of the MLL gene rearrangements, gender, age and white blood cell count showed no influence on the outcome of infant AML.
|
12802909 |
2003 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia.
|
16330435 |
2005 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
U19/Eaf2 interacts with ELL, a fusion partner of MLL in the (11;19) (q23;p13.1) translocation in acute myeloid leukemia.
|
17044034 |
2007 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
More than 30 fusions involving the MLL gene at 11q23 have been reported in acute myeloid leukemia (AML).
|
15382263 |
2004 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Microarray-detected high <i>BRE</i> gene expression has been found to be associated with better patient survival in AML (acute myeloid leukemia) with MLL-AF9 translocation, and radiotherapy-treated non-familial breast cancer.
|
31111759 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
MLL gene rearrangements were found in 27 of the 37 ALL cases (73 percent), and in all five AML cases.
|
8709635 |
1996 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Acute myeloid leukemia (AML) patients with chromosome 11q23 abnormalities or MLL rearrangements have a poor prognosis when treated with conventional chemotherapy.
|
11999359 |
2002 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Contrary to previous findings, the subtypes of AML with t(9;11)(p22;q23)MLLT3-MLL, AML without maturation and acute myelomonocytic leukemia emerged to be indicative of poor outcome.
|
26159683 |
2015 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The partial tandem duplication of the ALL1 (MLL) gene has been found in several such cases of AML, yet its frequency and clinical significance are unclear.
|
9426057 |
1998 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute myeloid leukemias (AML), and in mixed phenotype acute leukemias in infancy - a disease with extremely poor prognosis.
|
19835597 |
2009 |
|
Leukemia, Myelocytic, Acute
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in-situ hybridization (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while the original T-ALL exhibited a male karyotype with abnormalities of chromosomes 6, 8, and a t(10;14)(q24;q11.2).
|
16493618 |
2006 |