|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study molecular mechanisms, we cloned and characterized the MLL promoter region and used small interfering RNA for MLL and specific inhibitors for signal transduction pathways.
|
19318494 |
2009 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This targeting strategy does not affect other mixed-lineage leukemia (MLL) family histone methyltransferases (HMTs), revealing a unique regulatory feature for the MLL1 complex.
|
24389101 |
2014 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Upon androgen stimulation, AR recruits the Protein kinase N1 (PKN1), which phosphorylates histone H3 at threonine 11, with subsequent recruitment of tryptophan, aspartic acid (WD) repeat-containing protein 5 (WDR5) and the su(var)3-9, enhancer of zeste, trithorax/mixed-lineage leukemia (SET1/MLL) histone methyltransferase complex to promote AR target gene activation and prostate cancer cell growth.
|
27268279 |
2016 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this phase 1 study, pinometostat was evaluated for safety and efficacy in adult patients with advanced acute leukemias, particularly those involving mixed lineage leukemia (<i>MLL</i>) gene rearrangements (<i>MLL-r</i>) resulting from 11q23 translocations.
|
29724899 |
2018 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal rearrangements of the mixed lineage leukemia (MLL/KMT2A) gene leading to oncogenic MLL-fusion proteins occur in ~10% of acute leukemias and are associated with poor clinical outcomes, emphasizing the need for new treatment modalities.
|
27840424 |
2017 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The same differences concerning dCK and hENT1 mRNA expression were observed between MLL gene-rearranged (n = 14) and germ line MLL cases (n = 25).
|
12406912 |
2003 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangement of the mixed lineage leukemia (MLL; also known as lysine methyltransferase 2A) gene is a recurrent genomic aberration in acute myeloid leukemia (AML).
|
31789407 |
2020 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, ASH1L facilitates recruitment of LEDGF and wild-type MLL proteins to chromatin at key leukemia target genes and is a crucial regulator of MLL-dependent transcription and leukemic transformation.
|
27154821 |
2016 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The possible involvement of germline mutation of the ataxia telangiectasia mutated (ATM) gene in childhood acute leukemia with mixed lineage leukemia (MLL) gene rearrangement (MLL(+)) was investigated.
|
12511424 |
2003 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine the incidence of the mixed lineage leukemia (MLL) gene rearrangements in acute myeloid leukemia (AML) without cytogenetically-detected 11q23 abnormalities, we screened 64 cases of AML at diagnosis for MLL rearrangement by FISH.
|
11911106 |
2002 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization demonstrated a rearrangement of the MLL gene and molecular genetic analyses identified a septin family gene, SEPT2, located on chromosome 2q37, as the fusion partner of MLL.
|
16682951 |
2006 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also briefly summarize the clinicopathologic significance of MLL gene rearrangements, and review the reported cases of pediatric ovarian lymphoma with and without MLL rearrangement.
|
25493458 |
2015 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetic analyses revealed additional genetic aberrations including trisomy 8 and t(9;11)(p21;q23) involving the mixed lineage leukemia ( MLL) gene.
|
30935343 |
2019 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic rearrangements involving KMT2A gene are frequently involved in lymphoid, myeloid and mixed lineage leukemia.
|
28535805 |
2017 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Acute lymphoblastic leukemia (ALL) with mixed lineage leukemia (MLL) gene rearrangements (MLL+ALL) has a dismal prognosis and is characterized by high surface CD44 expression.
|
28569787 |
2017 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The consistent association of anthracylines (e.g., epirubicin and idarubicin) in inducing therapy-related acute leukemias (t-AL) with mixed lineage leukemia (MLL) gene rearrangement suggests that MLL translocations are causative events for t-AL.
|
24310817 |
2014 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mixed lineage leukemia (MLL/KMT2A) rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia.
|
31413090 |
2019 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving the Mixed Lineage Leukemia (MLL) gene generate in-frame fusions of MLL with more than 50 different partner genes (PGs).
|
21998658 |
2011 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal translocations involving the MLL gene are associated with infant acute lymphoblastic and mixed lineage leukemia.
|
20159561 |
2010 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Acute myeloid leukemias (AMLs) with translocations of the mixed lineage leukemia (MLL/KMT2A) gene are common in young patients and are generally associated with poor clinical outcomes.
|
28911906 |
2017 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The WHO 2008 classification further delineated three categories: associated with t(9;22)/BCR-ABL1 fusion gene, associated with KMT2A (mixed lineage leukemia) rearrangements, and nonotherwise specified.
|
31033213 |
2019 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report that acute myeloid leukemia (AML) with an aberrant histone methyltransferase, the mixed lineage leukemia partial tandem duplication (MLL-PTD), exhibits increased global DNA methylation versus AML with MLL-wildtype (MLL-WT; P = .02).
|
18566324 |
2008 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non-MLL-translocated cells.
|
21741596 |
2011 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fms-like tyrosine kinase 3 (FLT3) is highly expressed in mixed-lineage leukemia (MLL) gene-rearranged acute lymphoblastic leukemia (MLL+ALL) with a dismal prognosis.
|
28917156 |
2017 |
|
MIXED LINEAGE LEUKEMIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Despite many attempts to understand mixed-lineage leukemia (MLL leukemia), effective therapies for this disease remain limited.
|
30651276 |
2019 |