Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results indicate that mRNA expressions of MMP-1, -9,-11,-15,-24 and -25 were upregulated in breast cancer tissues when compared to normal breast tissues.
|
23568046 |
2013 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Herein we examined the regulation mechanism of heregulin- β1 (HRG)-induced MMP-1 and -9 expression in breast cancer cell lines.
|
22627808 |
2012 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Short hairpin RNA-mediated stable knockdown of MMP-1 inhibited the invasive ability of MDA-MB 231 variant cells in vitro, and inhibited breast cancer growth when the cells were injected into the mammary fat pad of nude mice.
|
23217186 |
2012 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, the search for the common polymorphic variants of MMPs, new genetic markers as prognostic factors in breast cancer progress seems to be understandable.The minireview presents the results of 19 case-control or prospective studies concerning the association of SNPs of genes encoding nine MMPs: MMP-1, -2, -3, -7, -8, -9, -12, -13, -21 with the breast cancer risk, progression and survival.
|
22296495 |
2012 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.
|
22011282 |
2011 |
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found no strong association between MMP1 variation and the risk of MM or breast cancer.
|
21642878 |
2011 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Using an ARE-gene microarray, novel targets of TTP regulation were identified, namely, urokinase plasminogen activator (uPA), uPA receptor and matrix metalloproteinase-1, all known to have prominent roles in breast cancer invasion and metastasis.
|
20498646 |
2010 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated MMP-1 and CXCR4 expression in normal human mammary fibroblasts (HMF) exposed to soluble breast cancer factors.
|
19584257 |
2009 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that breast cancer-derived MMP-1 mediates invasion through soft tissues and bone via mechanisms involving matrix degradation, angiogenesis, and osteoclast activation.
|
18597171 |
2009 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrate that HER2-induced MMP-1 expression is positively regulated by Ets-1 in breast cancer cells.
|
18851945 |
2008 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results suggest that MMP-1 is an important gene implicated in the progression of human breast cancer.
|
17663001 |
2008 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We examined MT1-MMP (MMP-14, membrane type-1-MMP), MMP-1 (interstitial collagenase) and MMP-3 (stromelysin-1) for their localisation profile in progressive breast cancer biopsy material (poorly differentiated invasive breast carcinoma (PDIBC), invasive breast carcinomas (IBC) and lymph node metastases (LNM)).
|
17669621 |
2008 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
MMP-1, -9, -12, -14 and -15, are associated with adverse outcome in patients with breast cancer.
|
18503039 |
2008 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
There was a positive correlation between hTERT mRNA expression (after CK19 normalisation) with both VEGF-D and MMP-1 in human breast cancer.
|
17695512 |
2007 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of this work was to investigate the influence of 1G/2G and C-->T polymorphisms on the MMP-1 and MMP-9 level and therefore on the occurrence and progression of breast cancer.
|
16267613 |
2006 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We utilised the unique in situ-reverse transcription-polymerase chain reaction (IS-RT-PCR) methodology to localise the in vitro and in vivo gene expression of MT1-MMP, MMP-1 and MMP-3 in human breast cancer.
|
16430785 |
2006 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cyr61-dependent loss of migration was complemented by exogenous MMP-1 and required the presence of the functional PAR1 receptor on the breast cancer cells.
|
16510585 |
2006 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our recent studies on breast carcinoma cell lines with differing tumorigenicity/invasiveness (MCF-7<MDA-MB-468<MDAMB-231<MDA-MB-435) had shown significantly decreasing expression levels of MMPs-1,-2,-3,-8,-9,-10,-11 and -13 with increasing cell density while the levels of TIMP-1 and -2 increased.
|
15841325 |
2005 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis.
|
15864312 |
2005 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased matrix metalloproteinase-1 (MMP-1) expression is associated with advanced stages of breast cancer and may be a predictive marker for the development of invasive disease.
|
16322260 |
2005 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, we examined MMP(-1,-2,-3,-8,-9,-10,-11 and -13) and TIMP-1/-2 expression of well-defined cell densities in breast carcinoma cell lines with differing in vivo tumorigenicity/invasiveness (MCF-7 < MDA-MB-468 < MDA-MB-231 < MDA-MB-435).
|
15777790 |
2005 |
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer.
|
15149160 |
2004 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Degradation of stromal collagens in the extracellular matrix is mediated largely by matrix metalloproteinase-1 (MMP-1; collagenase-1), and high constitutive levels of MMP-1 in breast cancer correlate with a poor prognosis and invasive disease.
|
14692651 |
2003 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of tissue inhibitor of matrix metalloproteinase-1 in human breast carcinoma.
|
10854560 |
2000 |