MMP2, matrix metallopeptidase 2, 4313

N. diseases: 1021; N. variants: 43
Disease: Childhood Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Thus preclinical validation of molecular interaction between diosgenin and NFE2L2 down-regulating MMP-2, EMT markers and promoting apoptosis, offers rationale for new therapeutic horizons in the field of glioblastoma management. 30885764 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE We showed a 20-fold upregulation of A<sub>2B</sub> AR on GB compared with sham, and its activation induced matrix metalloproteinase-2, which enhanced GB pathogenesis. 30926752 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Delineation of crosstalk between HSP27 and MMP-2/MMP-9: A synergistic therapeutic avenue for glioblastoma management. 31028823 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE Downregulation of the miR-221/222 cluster diminished the invasion, migration, proliferation, and angiogenesis with reduced protein levels of matrix metalloproteinase-2 (MMP-2), MMP-9, and vascular endothelial growth factor in glioblastoma cells. 31106423 2019