Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The present study examined the association of -1562C>T promoter polymorphism in the MMP9 gene with Primary Open Angle Glaucoma (POAG) and Primary Angle Closure Glaucoma (PACG) in a north Indian population.
|
29432439 |
2018 |
Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate common variants in MMP9 for association with PACG.
|
27272641 |
2016 |
Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We affirmed the association of PACG and combined PACS/PAC/PACG with 10 polymorphisms in 8 genes/loci, including COL11A1 (rs3753841-G, OR, 1.22; P = 0.00046), HGF (rs17427817-C, OR, 2.02; P = 6.9E-07; rs5745718-A, OR, 2.11; P = 9.9E-07), HSP70 (rs1043618, GG+GC, OR, 0.52; P = 0.0010), MFRP (rs2510143-C, OR, 0.66; P = 0.012; rs3814762-G, OR, 1.40; P = 0.0090), MMP9 (rs3918249-C, OR, 1.35; P = 0.034), NOS3 (rs7830-A, OR, 0.80; P = 0.036), PLEKHA7 (rs11024102-G, OR, 1.24; P = 8.3E-05), and PCMTD1-ST18 (rs1015213-A, OR, 1.59; P = 0.00013).
|
26854036 |
2016 |
Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In addition, a significant difference was observed in genotype frequencies of MMP9 rs17576 (c.836A>G) in patients with PACG compared to the control subjects (p < 0.001), which after gender stratification remained significant in men (p = 0.009) but not in women (p = 0.14).
|
23441116 |
2013 |
Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates an association between MMP9 SNPs rs3918249 and rs17576 and PACG in the Australian population, suggesting MMP9 may be involved in the pathogenesis of this blinding disease.
|
21655354 |
2011 |
Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the SNP rs17576 in MMP-9 might not be related to PACG in the same population.
|
19633731 |
2009 |
Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study did not find an association between the rs2664538 polymorphism within the MMP-9 gene and PACG in this sample of Chinese subjects.
|
18552608 |
2008 |
Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
LHGDN |
This study did not find an association between the rs2664538 polymorphism within the MMP-9 gene and PACG in this sample of Chinese subjects.
|
18552608 |
2008 |
Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
LHGDN |
Our results reveal that SNP rs2664538, which is located at the MMP9 gene, is likely to be associated with acute PACG.
|
17110919 |
2006 |
Angle Closure Glaucoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our results reveal that SNP rs2664538, which is located at the MMP9 gene, is likely to be associated with acute PACG.
|
17110919 |
2006 |