Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Our data showed that TAMs facilitate the EMT process via an MMP-9/PI3K/AKT/Snail dependent pathway, while blocking this signaling pathway with MMP-9 proenzyme inhibitor could suppress distant metastasis in gastric cancer.
|
31202170 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
This miRNA is a negative regulator of K-RAS, c-MYC, BCL-2, and MMP-9 genes which are engaged in tumor growth and metastasis.
|
31032951 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we report a molecular axis, comprising the molecular adaptor hydrogen peroxide-inducible clone-5 (HIC-5), NADPH oxidase 4 (NOX4), and mitochondria-associated reactive oxygen species (mtROS), that regulates MMP9 expression and may be a target to suppress cancer metastasis.
|
30281903 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
The invasion assay and detection of the E-cadherin and matrix metalloproteinases 9 (MMP-9) levels in xenografts demonstrated that TPM1 up-regulation inhibited tumor metastasis in RCC.
|
31258725 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
This 3D model can provide a microenvironment suitable for cell-cell and cell-matrix interactions whilst retaining the behaviour of BrCa cells with different metastasis potential (i.e., highly metastatic MDA-MB-231 and low metastatic MCF-7) as shown by the production of alkaline phosphatase and matrix metalloproteinase-9.
|
30466156 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF-C) are thought to be involved in tumor progression and metastasis.
|
30993496 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
These findings may indicate that down-regulation of VEGF and MMP-9 genes is directly related to angiogenesis and metastasis.
|
30315927 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
DT3 inhibited markers for epithelial (E-cadherin) to mesenchymal (vimentin) transition, metastasis (matrix metalloproteinase 9), angiogenesis VEGF, inflammation (NF-κB), and Wnt signaling (β-catenin) compared with vehicle in colorectal cancer cells.
|
30940630 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
PG significantly suppressed the phorbol 12-myristate 13-acetate (PMA)-induced increase of matrix metalloproteinase (MMP)-9 expression as well as gelatinolytic MMP-9 activity, which are essential for cancer metastasis.
|
30668328 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
MMP-9 has been considered as one of the principal mediators in regulation of not only the initial steps of cancer but during the invasion and spreading of cancer cells to distant organs.
|
30656360 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The expression level of STAT3, EZH2, β-catenin, and EMT and metastasis related molecules such as E-cadherin, N-cadherin, Snail-1 and MMP-9 was assessed by qRT-PCR and western blotting.
|
31102664 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that inhibiting individual soluble factors will not inhibit AAM-induced effects across a broad group of patients; instead, the downstream JAK2/STAT3/MMP-9 pathway should be examined as potential therapeutic targets to slow metastasis in ovarian cancer.
|
31129149 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Matrix metalloproteinase-9 (MMP9) has been recognized to be an important factor in cancer invasion and metastasis.
|
30655899 |
2019 |
Neoplasm Metastasis
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
The expression of Ezrin and matrix metalloprotease-9 (MMP-9), which are two mediator proteins that serve roles in tumor cell migration and invasion, were analyzed in each cell group via western blotting.
|
30655800 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are upregulated in most cancers and play crucial roles in modulating invasion and metastasis.
|
30074136 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our data indicate that circular matrix metalloproteinase 9 acts as a metastasis-promoting gene in oral squamous cell carcinoma through regulating the messenger RNA stability of its parental gene.
|
31510782 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Cells were treated with IC<sub>50</sub> concentration and then apoptosis-related (Casp-3, Casp-9, Bcl-2, and Bcl-xL), survival-related (Akt, p-Akt, Erk, and p-Erk), and metastasis-related (E-cadherin, Vimentin, MMP-2, and MMP-9) protein expressions were determined by Western blot analysis.
|
30628735 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
In A549 and H1299 cells, upregulation of ARHGAP6 inhibited tumor growth and metastasis and reduced the levels of MMP9, VEGF and p‑STAT3, while the levels STAT3 were unchanged, as demonstrated by CCK‑8, migration and invasion assays as well as western blot analysis.
|
30816546 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
It suppressed the expression of NF-κB and NF-κB-regulated gene products such as COX-2, survivin and MMP-9 which are involved in the regulation of different processes like proliferation, survival, invasion, and metastasis of OSCC cells.
|
31759370 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
As2S2 treatment also inhibited the protein expression of matrix metalloproteinase‑9 (MMP‑9), but increased the intracellular accumulation of ROS in the two breast cancer cell lines, which may assist in alleviating metastasis and attenuating the progression of breast cancer.
|
30320388 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
This study confirmed a new mechanism by which BMAL1 up-regulated MMP9 expression to increase breast cancer metastasis, to provide research support for the prevention and treatment of breast cancer.
|
31346317 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, overexpression of Fascin-1 in OS cells significantly increased their migratory capacity as well as the activity of the matrix metalloprotease MMP-9, known to be critical for the execution of metastasis.
|
30654764 |
2019 |
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
IHC analysis revealed that a high expression of <i>UCA1</i> was accompanied by a high expression of metastasis-related proteins (MMP-2 and MMP-9), thereby validating the correlation of <i>UCA1</i> expression with metastasis.
|
30863094 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have suggested a positive feedback loop between TGFβ1 and MMP-9 mediated by the PI3K signaling pathway that confers acquired invasion and metastasis in HCC via induction of the epithelial-mesenchymal transition (EMT), which grows into invasive carcinoma.
|
31499614 |
2019 |
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, these data suggest that the coexpression of CXCL8 and MMP9 could be an early detection marker for PNI, with a potential to be utilized as individual therapy targets for early treatment to prevent PNI-related cancer metastasis.
|
31681401 |
2019 |