MMP14, matrix metallopeptidase 14, 4323

N. diseases: 340; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1839326
Disease: Abnormal form of the vertebral bodies
Abnormal form of the vertebral bodies 		0.100 Biomarker phenotype HPO
CUI: C4025109
Disease: Abnormal hand morphology
Abnormal hand morphology 		0.100 Biomarker disease HPO
CUI: C4025863
Disease: Abnormality of the orbital region
Abnormality of the orbital region 		0.100 Biomarker phenotype HPO
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.010 AlteredExpression disease BEFREE EMMPRIN and MT1-MMP are upregulated on monocytes in acute MI. 16461815 2006
CUI: C0746731
Disease: Acute myocardial ischemia
Acute myocardial ischemia 		0.010 AlteredExpression disease BEFREE Modulation of MT1-MMP activity and microRNA-133a exportation into the myocardial interstitium occurred in the setting of acute myocardial ischemia-reperfusion. 23102905 2013
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.340 Biomarker group CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.340 AlteredExpression group BEFREE The results of this study support the previous suggestions of the importance of MT1-MMP for malignant growth and indicate that increased MT1-MMP mRNA expression by tumor cells in HCCs and pancreatic adenocarcinomas may have prognostic significance. 10914717 2000
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.340 Biomarker group BEFREE We now report that polarized exocytosis of MT1-MMP occurs during MDA-MB-231 adenocarcinoma cell migration into collagen type I three-dimensional matrices. 17332756 2007
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.340 AlteredExpression group BEFREE Both FGFR4 and MT1-MMP were upregulated in tissue biopsies from several human cancer types including breast adenocarcinomas, where they were partially coexpressed at the tumor/stroma border and tumor invasion front. 20876804 2010
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.340 AlteredExpression group BEFREE Our results indicate that MT1-MMP expression, together with that of TIMPs, is involved most notably in normal endometrium under progesterone effect and, without being connected to cyclic hormonal levels, has an important role in the invasive growth of endometrial adenocarcinomas. 10989641 2000
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		0.010 GeneticVariation disease BEFREE Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). 21472143 2011
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.020 Biomarker disease BEFREE MT1-MMP immunostaining was also detected in 80% (20/25) and 50% (5/10) of brain metastasis from lung adenocarcinoma and breast cancer, respectively. 19402080 2009
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.020 Biomarker disease BEFREE Collectively, we conclude that the novel FAM83A-AS1/miR-150-5p/MMP14 axis regulates LUAD progression, suggesting an innovative therapeutic strategy for this cancer. 31522616 2019
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell 		0.300 Biomarker disease CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143 2011
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic 		0.300 Biomarker disease CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143 2011
CUI: C0007135
Disease: Adenocarcinoma, Scirrhous
Adenocarcinoma, Scirrhous 		0.010 AlteredExpression disease BEFREE TIMP-3 mRNA levels inversely correlated with proMMP-2 activation ratios, although the expression levels of MT1-MMP and MT2-MMP were not different in SC and NSC. 15387372 2004
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular 		0.300 Biomarker disease CTD_human Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. 21472143 2011
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 AlteredExpression group BEFREE The proteins ADAM12 and MMP-14 were significantly up-regulated in invasive adenomas compared to noninvasive adenomas. 27144841 2016
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.010 AlteredExpression disease BEFREE Furthermore, through overexpression and silencing of RHBDF1 and the mediator complex, our study demonstrates that RHBDF1 may positively regulate adenomatous polyposis coli (APC) in the Wnt/β-catenin signalling pathway to increase the expression levels of MMP-14 and Twist, which act as important epithelial-to-mesenchymal transition (EMT) stimulating factors. 29654741 2018
CUI: C0206677
Disease: Adenomatous Polyps
Adenomatous Polyps 		0.010 Biomarker disease BEFREE The aim of this study was to determine the expression levels of MMP-2, MMP-9, MMP-7, MMP-13, and MMP-14 and their specific inhibitor TIMP-1 in inflammatory bowel diseases and precancerous lesions of the colon, i.e., Crohn's disease and ulcerative colitis, and in adenomatous polyps (APs) for comparison. 17075343 2006
CUI: C1332183
Disease: Adult Astrocytic Tumor
Adult Astrocytic Tumor 		0.010 AlteredExpression disease BEFREE MT3-MMP is detectable in both astrocytic tumor and normal brain tissues, but the mean expression level is approximately 50-fold lower compared with that of MT1-MMP and MT2-MMP in the glioblastomas. 10027400 1999
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.100 AlteredExpression disease BEFREE We demonstrated that anterior lens capsule type IV collagen or specifically the synthetic peptide alpha3(IV) 185-203 inhibited both the migration of melanoma or fibrosarcoma cells as well as the activation of membrane-bound MMP-2 by decreasing the expressions of MT1-MMP and the beta3 integrin subunit. 10667602 2000
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.100 Biomarker disease BEFREE We investigated the effect of hyperthermia on the production of MT1-MMP in human fibrosarcoma HT-1080 cells. 10548512 1999
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.100 Biomarker disease BEFREE A fibrosarcoma cell line transfected with the matrix metalloproteinase MT1 MMP showed an enhanced ability to degrade 14C-labelled collagen films. 11240131 2001
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.100 AlteredExpression disease BEFREE The presence of MT1-MMP oligomers also was shown for the enzyme naturally expressed in HT1080 fibrosarcoma cells. 11335709 2001