|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?
|
19796684 |
2009 |
|
Acrodysostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Modulation of signaling through GPCR-cAMP-PKA pathways by PDE4 depends on stimulus intensity: Possible implications for the pathogenesis of acrodysostosis without hormone resistance.
|
27908835 |
2017 |
|
Acth-Independent Macronodular Adrenal Hyperplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The ACTH MC2 receptor showed a low expression in 15 of 18 AIMAHs samples, whereas several previously undescribed GPCR genes were found highly expressed in a subset of AIMAH, such as the receptors for motilin (MLNR; three of 18 AIMAHs) and γ-aminobutyric acid (GABBR1; five of 18 AIMAHs), and the α2A adrenergic receptor (ADRA2A; 13 of 18 AIMAHs), on which we focused our attention.
|
20660048 |
2010 |
|
Acute Coronary Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
While the platelet glycoprotein IIb/IIIa is involved in the pathogenesis of acute coronary syndromes whereas most platelet activating stimuli act via G Protein coupled receptors we investigated whether the 825C>T polymorphism of the gene GNB3 encoding the G protein beta3 subunit together with the platelet glycoprotein (GP) IIIa Pl(A) polymorphism are predictive of platelet aggregability on stimulation with various agonists acting via GPCRs.
|
12818251 |
2003 |
|
Adrenal Cushing's syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of the study was to identify new GPCR targets for the pharmacological treatment of adrenal Cushing's syndrome.
|
20660048 |
2010 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vitro studies used PDX and 1321N1 glioblastoma cells to examine functional responses to sphingosine 1-phosphate (S1P), a GPCR agonist that activates RhoA signaling, demonstrated that YAP signaling was required for cell migration and invasion, whereas MRTF-A was required for cell adhesion; both YAP and MRTF-A were required for proliferation.
|
29887596 |
2018 |
|
Agnosia for Pain
|
0.020 |
Biomarker
|
disease |
BEFREE |
This finding further consolidates the pharmacological targeting of GPCRs by hemorphins as previously shown for the opioid receptors in analgesia opening a new era for investigating the role of hemorphins in physiology and pathophysiology <i>via</i> the targeting of GPCR pharmacology and signaling.
|
31708782 |
2019 |
|
Agnosia for Pain
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These results suggest a new molecular mechanism for CCK-8 antagonism to opioid analgesia in terms of G-protein-coupled receptor (GPCR) interaction through direct heteromerization.
|
29780163 |
2018 |
|
Albinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
One of the genes that causes albinism encodes for an orphan GPCR (OA1) expressed only in pigmented cells, including the RPE.
|
18828673 |
2008 |
|
Alcohol abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study suggests that RGS proteins may be potential new targets for intervention of alcohol abuse via modification of Gα-mediated GPCR function.
|
28736108 |
2017 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
The chemotactic G-protein-coupled receptor (GPCR) formyl-peptide-receptor like-1 (FPRL1) plays an essential role in the inflammatory responses of host defence mechanisms and neurodegenerative disorders such as Alzheimer's disease (AD).
|
21299846 |
2011 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Our study not only uncovers a molecular mechanism for the formation of a DOR/secretase complex that regulates the specificity of secretase for Abeta production but also suggests that intervention of either formation or trafficking of the GPCR/secretase complex could lead to a new strategy against AD, potentially with fewer side effects.
|
20066010 |
2010 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Collectively, these studies identify β-arrestin 2 as a new therapeutic target for reducing amyloid pathology and GPCR dysfunction in Alzheimer's disease.
|
23202293 |
2013 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
We present here for the first time a study analyzing the prevalence of GPCR-AABs in patients with different dementia forms such as unclassified, Lewy body, vascular and Alzheimer's dementia.
|
29538413 |
2018 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
In conclusion, interference with the p60TRP/ GPCR/secretase signalling pathway might be a new therapeutic target for the treatment of Alzheimer's disease (AD).
|
21199326 |
2011 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Understanding the role of calcium channels and GPCRs to maintain calcium homeostasis is an attempt to develop effective AD treatments.
|
31655116 |
2019 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
However, there is still a lack of insight into the mechanistic link between GPCR-mediated microglial activation and its pathological consequences in AD.
|
30186116 |
2018 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Monoamines and their Derivatives on GPCRs: Potential Therapy for Alzheimer's Disease.
|
30963972 |
2019 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cardiopulmonary function and structure, remodeling and apoptosis, as well as G protein‑coupled receptor (GPCR) and β2‑AR signaling, were documented over a period of 6 weeks.
|
29393391 |
2018 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Chemerin receptor (CMKLR1) is a G protein-coupled receptor (GPCR) implicated in macrophage-mediated inflammation and in several forms of human arthritis.
|
30576947 |
2019 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
GPCR genes implicated in asthma endophenotypes include variants of the cysteinyl leukotriene receptors (CYSLTR1 and CYSLTR2), and prostaglandin D2 receptors (PTGDR and CRTH2), thromboxane A2 receptor (TBXA2R), beta2-adrenergic receptor (ADRB2), chemokine receptor 5 (CCR5), and the G protein-coupled receptor associated with asthma (GPRA).
|
17154652 |
2006 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
A number of GPCR-targeting asthma drug candidates are also in different stages of development.
|
31767622 |
2020 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Studies involving EPI-2010, a respirable antisense oligonucleotide (RASON), targeting the adenosine A(1) receptor, a G-protein-coupled-receptor (GPCR) that plays an important role in the aetiology of asthma, demonstrate that ASON therapeutics can be delivered directly to the lung as an aerosol.
|
11728229 |
2001 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
GPR35 is a poorly characterized G protein-coupled receptor (GPCR) that has been suggested as a potential therapeutic target for the treatment of diabetes, hypertension and asthma.
|
21392828 |
2011 |
|
Autoimmune Diseases
|
0.050 |
Biomarker
|
group |
BEFREE |
Antibody-induced cell injury and the response to cell death amplify the loss of self-tolerance, which most likely helps to perpetuate GPCR-mediated autoimmunity.
|
29363585 |
2018 |